ORCID Profile
0000-0003-3446-2230
Current Organisations
International University
,
Nanyang Technological University
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Publisher: Elsevier BV
Date: 2021
Publisher: Elsevier
Date: 2019
Publisher: Elsevier BV
Date: 10-2019
DOI: 10.1016/J.MSEC.2019.04.049
Abstract: The purpose of this research is to investigate the effect of different oxidation degrees and volume ratios of components on the physical properties and biocompatibility of an in situ cross-linking chitosan-hyaluronic acid-based hydrogel for skin wound healing applications. Carboxymethyl groups (-CH
Publisher: Elsevier BV
Date: 03-2021
Publisher: Informa UK Limited
Date: 29-01-2019
Publisher: Springer Singapore
Date: 24-09-2017
Publisher: MDPI AG
Date: 10-08-2021
DOI: 10.3390/MA14164475
Abstract: The use of naturally occurring materials with antibacterial properties has gained a great interest in infected wound management. Despite being an abundant resource in Vietnam, chitosan and its derivatives have not yet been intensively explored for their potential in such application. Here, we utilized a local chitosan source to synthesize chitosan oligomers (OCS) using hydrogen peroxide (H2O2) oxidation under the microwave irradiation method. The effects of H2O2 concentration on the physicochemical properties of OCS were investigated through molecular weight, degree of deacetylation, and heavy metal contamination for optimization of OCS formulation. Then, the antibacterial inhibition was examined the minimum inhibitory concentration and minimum bactericidal concentration (MIC and MBC) of OCS-based materials were determined against common skin-inhabitant pathogens. The results show that the local Vietnamese chitosan and its derivative OCS possessed high-yield purification while the molecular weight of OCS was inversely proportional and proportional to the concentration of H2O2, respectively. Further, the MIC and MBC of OCS ranged from 3.75 to less than 15 mg/mL and 7.5–15 mg/mL, respectively. Thus, OCS-based materials induce excellent antimicrobial properties and can be attractive for wound dressings and require further investigation.
No related grants have been discovered for Nam Minh-phuong Tran.