ORCID Profile
0000-0003-3620-7671
Current Organisations
Hospital Universitari de Bellvitge - IDIBELL
,
RTI Health Solutions
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Publisher: Cambridge University Press (CUP)
Date: 2021
DOI: 10.1017/S0950268821001618
Abstract: UK universities re-opened in September 2020, amidst the coronavirus epidemic. During the first term, various national social distancing measures were introduced, including banning groups of people and the second lockdown in November however, outbreaks among university students occurred. We aimed to measure the University of Bristol staff and student contact patterns via an online, longitudinal survey capturing self-reported contacts on the previous day. We investigated the change in contacts associated with COVID-19 guidance periods: post-first lockdown (23/06/2020–03/07/2020), relaxed guidance period (04/07/2020–13/09/2020), ‘rule-of-six’ period (14/09/2020–04/11/2020) and the second lockdown (05/11/2020–25/11/2020). In total, 722 staff (4199 responses) and 738 students (1906 responses) were included in the study. For staff, daily contacts were higher in the relaxed guidance and ‘rule-of-six’ periods than the post-first lockdown and second lockdown. Mean student contacts dropped between the ‘rule-of-six’ and second lockdown periods. For both staff and students, the proportion meeting with groups larger than six dropped between the ‘rule-of-six’ period and the second lockdown period, although was higher for students than for staff. Our results suggest university staff and students responded to national guidance by altering their social contacts. Most contacts during the second lockdown were household contacts. The response in staff and students was similar, suggesting that students can adhere to social distancing guidance while at university. The number of contacts recorded for both staff and students were much lower than those recorded by previous surveys in the UK conducted before the COVID-19 pandemic.
Publisher: F1000 Research Ltd
Date: 14-05-2021
DOI: 10.12688/WELLCOMEOPENRES.16785.1
Abstract: Background: Coronavirus disease 2019 (COVID-19) has exposed health inequalities within countries and globally. The fundamental determining factor behind an in idual’s risk of infection is the number of social contacts they make. In many countries, physical distancing measures have been implemented to control transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), reducing social contacts to a minimum. We characterise social contacts to understand the drivers and inequalities behind differential risks for aiding in planning SARS-CoV-2 mitigation programmes. Methods: We utilised an existing longitudinal birth cohort (n=6807) to explore social contact patterns and behaviours when strict physical distancing measures were in place during the UK’s first lockdown in March-May 2020. We used an online questionnaire to capture information on participant contact patterns, health, SARS-CoV-2 exposure, behaviours and impacts resulting from COVID-19. We quantified daily contacts and examined the association between covariates and numbers of daily total contacts using a negative binomial regression model. Results: A daily average of 3.7 [standard deviation = 10.6] total contacts outside the household were reported. Essential workers, specifically those in healthcare, had 4.5 times as many contacts as non-essential workers [incident rate ratio = 4.42 (95% CI: 3.88–5.04)], whilst essential workers in other sectors, mainly teaching and the police force had three times as many contacts [IRR = 2.84 (2.58–3.13)]. The number of in iduals in a household, which largely reflects number of children, increases essential social contacts by 40%. Self-isolation effectively reduces numbers of contacts outside of the home, but not entirely. Conclusions: Contextualising contact patterns has highlighted the health inequalities exposed by COVID-19, as well as potential sources of infection risk and transmission. Together, these findings will aid the interpretation of epidemiological data and impact the design of effective control strategies for SARS-CoV-2, such as vaccination, testing and contact tracing.
Publisher: Springer Science and Business Media LLC
Date: 27-05-2019
DOI: 10.1038/S41598-019-44450-6
Abstract: Orexins/hypocretins are neuropeptides implicated in numerous processes, including food intake and cognition. The role of these peptides in the psychopathology of anorexia nervosa (AN) remains poorly understood. The aim of the current study was to evaluate the associations between plasma orexin-A (OXA) concentrations and neuropsychological functioning in adult women with AN, and a matched control group. Fasting plasma OXA concentrations were taken in 51 females with AN and in 51 matched healthy controls. Set-shifting was assessed using the Wisconsin Card Sorting Test (WCST), whereas decision making was measured using the Iowa Gambling Task (IGT). The AN group exhibited lower plasma OXA levels than the HC group. Lower mean scores were obtained on the IGT in AN patients. WCST perseverative errors were significantly higher in the AN group compared to HC. In both the AN and HC group, OXA levels were negatively correlated with WCST non-perseverative errors. Reduced plasma OXA concentrations were found to be associated with set-shifting impairments in AN. Taking into consideration the function of orexins in promoting arousal and cognitive flexibility, future studies should explore whether orexin partly underpins the cognitive impairments found in AN.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Sarah Sauchelli.