ORCID Profile
0000-0002-3630-6568
Current Organisations
University of Southampton
,
University of Oxford
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Publisher: BMJ
Date: 10-2020
DOI: 10.1136/BMJDRC-2020-001782
Abstract: India has high mortality rates from cardiovascular disease (CVD). Understanding the trends and identifying modifiable determinants of CVD risk factors will guide preventive strategies and policy making. CVD risk factors (obesity, central obesity, and type 2 diabetes (T2D), hypertension, hypercholesterolemia and hypertriglyceridemia) prevalence and incidence were estimated in 962 (male 519) non-migrant adults from Vellore, South India, studied in: (1) 1998–2002 (mean age 28.2 years) and (2) 2013–2014 (mean age 41.7 years). Prevalence was compared with the Non-Communicable Disease Risk Collaboration (global) data. Incidence was compared with another Indian cohort from New Delhi Birth Cohort (NDBC). Regression analysis was used to test baseline predictors of incident CVD risk factors. The prevalence at 28 and 42 years was 17% (95% CI 14% to 19%) and 51% (95% CI 48% to 55%) for overweight/obesity, 19% (95% CI 17% to 22%) and 59% (95% CI 56% to 62%) for central obesity, 3% (95% CI 2% to 4%) and 16% (95% CI 14% to 19%) for T2D, 2% (95% CI 1% to 3%) and 19% (95% CI 17% to 22%) for hypertension and 15% (95% CI 13% to 18%) and 30% (95% CI 27% to 33%) for hypertriglyceridemia. The prevalence of T2D at baseline and follow-up and hypertension at follow-up was comparable with or exceeded that in high-income countries despite lower obesity rates. The incidence of most risk factors was lower in Vellore than in the NDBC. Waist circumference strongly predicted incident T2D, hypertension and hypertriglyceridemia. A high prevalence of CVD risk factors was evident at a young age among Indians compared with high and upper middle income countries, with rural rates catching up with urban estimates. Adiposity predicted higher incident CVD risk, but the prevalence of hypertension and T2D was higher given a relatively low obesity prevalence. Preventive efforts should target both rural and urban India and should start young.
Publisher: Cold Spring Harbor Laboratory
Date: 04-07-2020
DOI: 10.1101/2020.07.03.20145599
Abstract: To estimate the prevalence, incidence and predictors of cardiovascular disease (CVD) risk factors in the Vellore Birth Cohort, South India. Prospective, cohort study Population-based cohort of rural and urban communities in and around Vellore city in South India Non-migrant in iduals (n= 962, male 519) were studied at two time points 13.6 years apart i) 1998-2002 (baseline, mean age 28.2 years) and ii) 2013-2014 (follow-up, mean age 41.7 years). Prevalence and incidence of CVD risk factors (obesity, central obesity, type 2 diabetes (T2D), hypertension, hypercholesterolemia and hypertriglyceridemia) studied at baseline (1998-2002) and follow-up (2013-2014), prevalence in comparison with the Non-Communicable Disease Risk Collaboration (global) data, incidence in comparison with another Indian cohort from New Delhi (NDBC), and baseline predictors of incident CVD risk factors. The prevalence at 28 and 42 years was 17% and 51% for overweight/obesity, 19% and 59% for central obesity, 3% and 16% for T2D, 2% and 19% for hypertension and 15% and 30% for hypertriglyceridemia. The prevalence of T2D at baseline and follow-up and hypertension at follow-up was comparable with or exceeded that in high income countries despite lower obesity rates. The incidence of most risk factors was lower in Vellore than in the NDBC. Waist circumference strongly predicted incident T2D, hypertension and hypertriglyceridemia. A high prevalence of CVD risk factors was evident at a young age among Indians compared with high and upper-middle income countries, with rural rates catching up with urban estimates. Adiposity predicted higher incident CVD risk, but the prevalence of hypertension and T2D was higher given a relatively low obesity prevalence in global terms. Our findings highlight a high burden of CVD risk factors at younger age with increasing trends observed among rural residents, similar to urban South Indians. Therefore, strategies to prevent CVD should be strengthened in both rural and urban settings to minimise health inequalities and should start young. None Cardiovascular disease (CVD) risk burden is increasing in Low- and middle-income countries and contributes significantly to the overall morbidity and mortality. Nation-wide data from India demonstrate heterogeneity in the prevalence of CVD risk factors within the country there is very little incidence data. The prevalence of CVD risk factors in India is comparable with or exceeds that in high income countries like USA and Europe, even though obesity levels are lower. Adiposity at baseline, particularly waist circumference, is a strong predictor of incident risk factors. The prevalence of CVD risk factors is higher in rural than urban communities, but the incidence is comparable or higher in the rural setting indicating that the rural population are catching up
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Senthil Vasan.