ORCID Profile
0000-0003-3307-3970
Current Organisation
Hokkaido University
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Publisher: Wiley
Date: 09-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3TC32101K
Publisher: American Chemical Society (ACS)
Date: 23-05-2023
Publisher: Wiley
Date: 18-02-2020
Abstract: Light-molecule strong coupling has emerged within the last decade as a new method to control chemical reactions. A few years ago it was discovered that chemical reactivity could be altered by vibrational strong coupling (VSC). Only a limited number of reactions have been investigated under VSC to date, including solvolysis and deprotection reactions. Here the effect of VSC on a series of aldehydes and ketones undergoing Prins cyclization, an important synthetic step in pharmaceutical chemistry, is investigated. A decrease of the second-order rate constant with VSC of the reactant carbonyl stretching groups is observed. We also observe an increased activation energy due to VSC, but proportional changes in activation enthalpy and entropy, suggesting no substantive change in reaction pathway. The addition of common cycloaddition reactions to the stable of VSC-modified chemical reactions is another step towards establishing VSC as a genuine tool for synthetic chemistry.
Publisher: Springer Berlin Heidelberg
Date: 2013
DOI: 10.1007/430_2013_106
Publisher: American Chemical Society (ACS)
Date: 30-06-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1SC03706D
Abstract: Strong coupling of optical cavity vacuum fields and solvent vibrations leads to selective crystallization in a pseudo-polymorphic MOF system.
Publisher: American Chemical Society (ACS)
Date: 23-12-2019
DOI: 10.26434/CHEMRXIV.11393928.V1
Abstract: Light-molecule strong coupling has emerged within the last decade as an entirely new method to control chemical reactions. A few years ago it was discovered that the chemical reactivity could be altered by vibrational strong coupling (VSC). While the potential of VSC in organic chemistry appears enormous, only a limited number of reactions have been investigated under VSC to date, including solvolysis and deprotection reactions. Here we investigate the effect of VSC on a series of aldehydes and ketones undergoing Prins cyclization, an important synthetic step in pharmaceutical chemistry. We observe a decrease of the second-order rate constant with VSC of the reactant carbonyl stretching groups. We measure an increased activation energy due to VSC, but proportional changes in activation enthalpy and entropy suggest no substantive change in reaction pathway. The addition of common cycloaddition reactions to the stable of VSC-modified chemical reactions is another step towards establishing VSC as a genuine tool for synthetic chemistry.
Publisher: American Chemical Society (ACS)
Date: 10-03-2020
Location: No location found
Location: United States of America
No related grants have been discovered for Kenji Hirai.