ORCID Profile
0000-0002-5917-633X
Current Organisations
Shahid Beheshti University of Medical Sciences
,
Mercy Hospital for Women
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Publisher: Briefland
Date: 31-12-2022
DOI: 10.5812/PMCO-133563
Abstract: : An emerging area of computer science is artificial intelligence (AI), which involves creating machines capable of learning, reasoning, and solving problems in the same way as humans. There is increasing use of machine learning techniques in the medical field, along with image recognition, language processing, and data mining, ranging from automated image analysis to disease prediction. Neurosurgery is frequently regarded as a pioneer in developing disruptive and innovative technologies that have significantly altered the course of acute and chronic disorders, such as epilepsy and brain tumors. Artificial intelligence platforms have been developed in recent decades to contribute to the paradigm shift in brain tumor surgery. Artificial intelligence platforms can result in safer and more effective brain tumor surgery. Artificial intelligence will soon be used to evaluate, analyze, and provide high-quality medical care. Robots will also become more prevalent in neurosurgery. Hence, physicians must keep up with this revolution to personalize patient care and deliver meaningful outcomes. For neurosurgeons to continue providing high-quality care in the future, they must understand artificial intelligence and utilize it effectively.
Publisher: Briefland
Date: 19-02-2019
DOI: 10.5812/AAPM.86963
Publisher: DoNotEdit
Date: 05-09-2014
DOI: 10.5812/IRCMJ.20153
Publisher: Briefland
Date: 25-02-2018
Publisher: Frontiers Media SA
Date: 08-08-2022
DOI: 10.3389/FMOLB.2022.884705
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder whose early diagnosis leads to a chance for successful treatment and decreases the side effects. Hyperphosphorylation of tau proteins is a pathological hallmark of AD that causes it to lose its attachment ability to the microtubules. Alteration of tau structure due to its hyperphosphorylation is an exciting challenge regarding AD treatments. Here, we aimed to examine the structural alterations of short helical segments of tau protein with one to three phosphorylated sites by molecular dynamics simulation. Results indicated that the interaction of two similar segments with three phosphorylated sites (P-Ser262, 285, and 289) formed a compact and more stable structure than the one phosphorylated site complex (P-Ser262). Moreover, due to the high dynamics of the P-Ser262 complex, several structures were made with different conformational dynamics, but there was only one stable cluster of the P-Ser262, 285, and 289 complex during simulation. It seems that the P-Ser262, 285, and 289 complex plays an important role in the formation of paired helical filaments (PHFs) by forming a stable dimer. Generally, it is important to identify how structural features of segments in tau protein change when the phosphorylated sites increase from one to three sites and their effects on the formation of PHFs for drug design and diagnostic biomarkers.
Publisher: Briefland
Date: 08-03-2014
DOI: 10.5812/AAPM.12091
Publisher: Briefland
Date: 26-03-2016
DOI: 10.5812/AAPM.33193
Publisher: Knowledge E
Date: 18-12-2021
DOI: 10.18502/ACTA.V59I12.8066
Abstract: The severity of COVID-19 disease and its mortality may be due to a localized vascular problem owing to the activation of bradykinin B1 receptors on endothelial cells in the lungs that occur following inflammation. Bromelain acts as an anti-inflammatory factor and can lower the level of bradykinin in the serum and tissues. Patients with the novel coronavirus (COVID-19) referred to Masih Daneshvari Hospital in Tehran were included in the study after providing full explanations and obtaining written consent. The 40 patients with mild to moderate symptoms were randomly ided into the control group (No: 20) and s le (No: 20). In the s le group, a dose of 200 mg bromelain was given to patients every 8 hours. In the control group, placebo capsules were administered exactly at the above intervals. Clinical and paraclinical factors (including SaO2, RR body temperature, MAP, HR, CRP, ESR, AST, ALT, Bil, BUN, Cr, WBC, Lymph, LDH, Plt were evaluated on a regular basis for up to five days. The results were evaluated using t-test and SPSS21 software. After treatment, the s le (Bromelain) group indicated significant improvement in SaO2, RR, HR, AST, ALT, BUN, ESR, LDH, and WBC and Lymphocyte count (P .05). Other factors did not have a significant difference with the control group. Bromelain causes improvement in some clinical symptoms such as respiratory parameters and para clinical items of mild to moderate hospitalized COVID-19 patients, so it can be a promising treatment. Furthered evaluation of larger groups is recommended.
Publisher: Maad Rayan Publishing Company
Date: 27-03-2021
Publisher: Kowsar Medical Institute
Date: 25-01-2014
Publisher: Briefland
Date: 09-2013
DOI: 10.5812/AAPM.10587
Publisher: Briefland
Date: 19-02-2015
DOI: 10.5812/AAPM.27470
Publisher: Elsevier BV
Date: 09-2011
DOI: 10.1016/J.AJEM.2010.01.046
Abstract: Tetanus vaccine and immunoglobulin administration are challenging decisions mostly because of the fact that the current protocol for immunization against tetanus is based on 2 variables: the vaccination status of the patient and the nature of wound and its exposure. To solve this problem, Tetanus Quick Stick (TQS Nephrotek Laboratory, Rungis, France), an immunochromatographic dipstick test, was developed to determine the tetanus immunity of the patients. The aim of this present study was to investigate the sensitivity, specificity, and the positive and negative predictive values and cost-effectiveness of TQS in the emergency department (ED) setting. Blood s les were collected from 200 patients presenting to our ED. Information including demographic information, tetanus immunization status, wound description, and the preventive measures taken by the emergency physician were gathered by a preeducated nurse. Tetanus Quick Stick test and enzyme-linked immunosorbent assay were performed as the standard diagnostic test by an emergency physician and a laboratory technician, respectively and results of the 2 techniques were compared. Overall, tetanus vaccine was administered to 141(70.5%) patients and immunoglobulin to 105 (52.5%) patients. The analysis revealed 88.1% sensitivity and 97.6% specificity for the TQS test. The positive and negative predictive values of TQS test were 99.3% and 66.1%, respectively. Our analysis is also showed a significant decrease in cost when TQS was applied for patients with dirty, tetanus prone wounds or injuries and unknown or incomplete vaccination history (€ 9.48 versus € 12.1). This study revealed TQS test to be appropriate and cost-effective for ED use especially in evaluating patients who do not remember or cannot give their tetanus immunization history.
Publisher: Kowsar Medical Institute
Date: 26-05-2013
Publisher: Briefland
Date: 14-03-2022
DOI: 10.5812/AAPM.120478
Abstract: Background: In patients under general anesthesia, the laryngeal mask airway (LMA) is a valuable alternative to endotracheal intubation to maintain the airway. In this study, we compared the efficacy of LMA with an endotracheal tube (ETT) in plastic and reconstructive surgeries over 2 h on thorax and abdomen under general anesthesia in Hazrat Fatemeh Hospital in Tehran, Iran, in 2020. Methods: This randomized clinical trial was performed on a s le size of 80, randomly assigned to two groups. The main variables included the ease of placement, recurrent carbon dioxide content, arterial oxygen saturation, and laryngeal and tracheal spasm. In addition, the sub-variables entailed the mean duration of anesthesia, nausea and vomiting, sore throat, and abdominal distension. The obtained data were analyzed by the SPSS software version 25. Results: In the present study, 76 patients were female. Mean age, recurrent carbon dioxide, arterial oxygen saturation, laryngeal and tracheal spasm, the mean duration of anesthesia, nausea and vomiting, sore throat, and abdominal distension were not significantly different between the two groups. Conclusions: The results of this study showed that the classic laryngeal mask could be used as a means of airway control in general anesthesia for long-term surgeries of more than 2 h.
Publisher: Briefland
Date: 10-08-2016
DOI: 10.5812/AAPM.37822
Publisher: Elsevier BV
Date: 03-2010
Publisher: Maad Rayan Publishing Company
Date: 09-05-2021
DOI: 10.34172/PS.2021.26
Abstract: The coronavirus 2019 disease (COVID-19) is an ongoing outbreak of respiratory disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus can invade various tissues and organs, causing multiple organ dysfunctions. Critically ill COVID-19 patients may develop acute respiratory distress syndrome and pneumonia, which are the major causes of hypoxemic respiratory failure and death due to SARS-CoV-2 infection. Thus, ventilation support (invasive or noninvasive), has become a common practice in respiratory treatment of COVID-19 patients. Patients receiving mechanical ventilation usually require sedation to alleviate anxiety, pain and discomfort. On the other hand, current clinical reports have indicated that a significant number of COVID-19 patients require prolonged intensive care unit (ICU) care and ventilation, which increases the risk of delirium. Thus, selection of appropriate sedative medications during this period is of utmost importance. Dexmedetomidine (DEX) is a sedative, anxiolytic and analgesic agent that acts through the α2-adrenoceptor. Its sedative property is notable due to the lack of respiratory depression. In addition, its cytoprotective, immunoregulatory and anti-inflammatory properties have been well established in preclinical settings. Based on these features, a number of recent studies have proposed DEX as a beneficial sedative agent that simultaneously mitigates the excessive inflammation and protects vital body organs in patients with severe COVID-19. In current brief review, we aimed to discuss the therapeutic benefits of DEX in managing different indications of COVID-19.
Publisher: Briefland
Date: 14-03-2014
DOI: 10.5812/AAPM.15499
Publisher: Briefland
Date: 28-02-2021
DOI: 10.5812/AAPM.111641
Publisher: Briefland
Date: 26-12-2014
DOI: 10.5812/AAPM.13871
Publisher: Briefland
Date: 02-02-2014
DOI: 10.5812/AAPM.16222
Publisher: Medknow
Date: 2011
Publisher: Briefland
Date: 09-2014
DOI: 10.5812/AAPM.21365
Publisher: Briefland
Date: 10-01-2013
DOI: 10.5812/AAPM.9903
Publisher: Briefland
Date: 06-01-2012
DOI: 10.5812/AAPM.6916
Publisher: Briefland
Date: 11-07-2017
DOI: 10.5812/AAPM.57568
Publisher: Briefland
Date: 07-2013
DOI: 10.5812/AAPM.10877
Publisher: DoNotEdit
Date: 05-09-2014
DOI: 10.5812/IRCMJ.21366
Publisher: Briefland
Date: 19-01-2012
Publisher: Springer Science and Business Media LLC
Date: 24-11-2021
Publisher: MDPI AG
Date: 15-04-2020
Abstract: The introduction of polymerase chain reaction (PCR) techniques has improved the detection of respiratory viruses, particularly with the use of multiplex real-time technique with the capability of simultaneous detection of various pathogens in a single reaction. The aim of this study was to apply the above technology for the diagnosis of influenza infections and at the same time to differentiate between common flu species between hospitalized patients in Laleh hospital (Iran) between two flu seasons (2016- 2017 and 2017-2018). Different respiratory specimens were collected from 540 patients from a period of December 2016 to May 2018 and were sent to the laboratory for molecular diagnosis. RNAs were extracted and subsequently, a multiplex real time PCR identifying flu A, flu B and typing flu A (H1N1) was carried out. The mean age of patients was 47.54±23.96. 216 (40%) and 321 (60%) of subjects were male and female, respectively. 219 out of 540 (40.5%) were positive for influenza infection including flu A (n=97, 44.3%), flu A (H1N1) (n=45, 20.7%) and flu B (n=77, 35%). Flu A was the dominant species on 2016-2017 and flu B was the major species on 2017-2018. Flu A (H1N1) was comparable in both time periods. Flu infections were most frequently diagnosed in age groups 21-40. Flu-positive patients suffered more from body pain and sore throat than flunegative patients with significant statistical difference (P values .001). The mean duration of hospitalization was shorter for flu-positive patients (P value = 0.016). Application of multiplex real time PCR could facilitate the influenza diagnosis in a short period of time, benefiting patients from exclusion of bacterial infections and avoiding unnecessary antibiotic therapy. Influenza diagnosis was not achieved in up to 60% of flu-like respiratory infections, suggesting the potential benefit of adopting the same methodology for assessing the involvement of other viral or/and bacterial pathogens in those patients.
Publisher: Medknow
Date: 2009
Publisher: Briefland
Date: 30-01-2014
DOI: 10.5812/AAPM.15546
Publisher: Springer Science and Business Media LLC
Date: 2009
Publisher: Briefland
Date: 06-04-2014
DOI: 10.5812/AAPM.7291
Publisher: Briefland
Date: 06-2014
Publisher: Briefland
Date: 25-06-2014
Publisher: Elsevier BV
Date: 07-2010
DOI: 10.1016/J.UROLOGY.2009.09.087
Abstract: To evaluate and compare the efficacy of botulinum toxin intravesical injections with and without injections in external urethral sphincter in treating bladder hyper-reflexia in children suffering from myelomeningocele. A total of 60 patients with bladder hyper-reflexia due to myelomeningocele were randomly allocated to treatment groups A and B and were followed up for 6 months. Under cystoscopic guidance, 10 IU/kg of botulinum toxin A was injected into the detrusor muscle, sparing the trigone and ureteral orifices in group A. Group B received 8 IU/kg of toxin via the same method compared with group A and 2 IU/kg of toxin through 4 injections in external urethral sphincter. Conventional urodynamics, daily incontinence score, constipation, and creatinine level were evaluated at baseline, 3 months, and 6 months after intervention. Vesicoureteral reflux was also assessed before and after 3 months of injections. All patients showed significant improvement in bladder capacity (P <.01), maximal detrusor pressure (P <.01), and detrusor-sphincter dyssynergia (P <.01) after 3 and 6 months of receiving injections. Significant improvement in postvoiding residual volume was observed only among patients of group B (P <.05). Both methods resulted in a significant reduction in daily incontinence grade, constipation, and vesicoureteral reflux (P <.05), but comparison between the study groups showed better outcomes for group B in relation to incontinency, constipation, vesicoureteral reflux, and creatinine level. Botulinum toxin type A injections in both sphincter and detrusor seems to have extra benefits such as decreasing postvoiding residual volume and more symptom diminution compared with intradetrusal injections alone.
Publisher: Frontiers Media SA
Date: 22-06-2021
Abstract: Background: Early prediction of symptoms and mortality risks for COVID-19 patients would improve healthcare outcomes, allow for the appropriate distribution of healthcare resources, reduce healthcare costs, aid in vaccine prioritization and self-isolation strategies, and thus reduce the prevalence of the disease. Such publicly accessible prediction models are lacking, however. Methods: Based on a comprehensive evaluation of existing machine learning (ML) methods, we created two models based solely on the age, gender, and medical histories of 23,749 hospital-confirmed COVID-19 patients from February to September 2020: a symptom prediction model (SPM) and a mortality prediction model (MPM). The SPM predicts 12 symptom groups for each patient: respiratory distress, consciousness disorders, chest pain, paresis or paralysis, cough, fever or chill, gastrointestinal symptoms, sore throat, headache, vertigo, loss of smell or taste, and muscular pain or fatigue. The MPM predicts the death of COVID-19-positive in iduals. Results: The SPM yielded ROC-AUCs of 0.53–0.78 for symptoms. The most accurate prediction was for consciousness disorders at a sensitivity of 74% and a specificity of 70%. 2,440 deaths were observed in the study population. MPM had a ROC-AUC of 0.79 and could predict mortality with a sensitivity of 75% and a specificity of 70%. About 90% of deaths occurred in the top 21 percentile of risk groups. To allow patients and clinicians to use these models easily, we created a freely accessible online interface at www.aicovid.net . Conclusion: The ML models predict COVID-19-related symptoms and mortality using information that is readily available to patients as well as clinicians. Thus, both can rapidly estimate the severity of the disease, allowing shared and better healthcare decisions with regard to hospitalization, self-isolation strategy, and COVID-19 vaccine prioritization in the coming months.
Publisher: Maad Rayan Publishing Company
Date: 05-11-2019
Publisher: Briefland
Date: 31-07-2022
DOI: 10.5812/IPMN-123157
Abstract: : Since the emergence of ultrasonography, many specialists, including anesthesiologists, have become interested in its practices. Technological innovations in portable ultrasonography devices and their quality enable anesthesiologists to use ultrasonography in various medical conditions and improve their diagnostic and therapeutic interventions. This article clarifies the significance of point-of-care ultra-sonography (POCUS) and highlights the challenges ahead. POCUS can help regional anesthesiologists and pain physicians in vascular access, airway management, focused cardiac ultra-sound (FoCUS), lung ultrasound, gastric ultrasound, focus assessment with sonography in trauma (FAST), regional and neuraxial nerve blocks, and acute and chronic pain management. However, similar to any new clinical method, there are challenges to POCUS, especially in developing countries like Iran. These challenges include the need for more budget allocation for medical equipment and portable devices, developing a comprehensive local curriculum and transparent framework to train residents and postgraduates, creating and/or revising university policies, clinical coordination with healthcare networks, and collaboration with healthcare providers. This article expresses the importance and effectiveness of point-of-care sonography performed by anesthesiologists and pain specialists in Iran and highlights the challenges ahead.
Publisher: Knowledge E
Date: 07-11-2022
Abstract: Paraquat dichloride (PQ) poisoning is a relatively rare yet critical medical condition that has a high case fatality rate. Lung tissue is highly susceptible to PQ-induced injury, and respiratory failure is the leading cause of death in these patients. Unfortunately, there is a lack of an effective therapeutic approach to ameliorate outcomes. It is well-known that PQ interferes with a variety of cell signaling pathways and induces the generation of reactive oxygen species (ROS), which ultimately results in cell injury. The traditional treatment decisions have not been able to significantly change the clinical course of PQ poisoning. Moreover, novel therapeutic strategies for PQ poisoning have centered on the inhibition of PQ-induced signaling pathways. In the current review, we sought to provide a bird’s-eye view of the available therapeutic approaches in patients with PQ poisoning.
Publisher: Springer Science and Business Media LLC
Date: 11-08-2016
Publisher: Briefland
Date: 25-02-2014
Publisher: Briefland
Date: 21-06-2014
Publisher: Ukrainian Society of Ophthalmologists
Date: 14-02-2021
Publisher: Frontiers Media SA
Date: 2014
Abstract: Hepatitis C virus (HCV) infection, with an estimated 170 million carriers worldwide, remains a major cause of chronic liver disease. Current anti-HCV treatments have significant side effects and have met with only partial success. Therefore, a more effective therapeutic modality for HCV infection is needed. The stability and propagation of HCV is dependent on the interaction between its genome and a highly abundant liver microRNA (miRNA), known as microRNA-122 (miR-122). As a conserved host factor that would not be expected to evolve resistance mutations, miR-122 makes an attractive antiviral target. In this review we will discuss how targeting miR-122, using antisense oligonucleotides (ASOs), can be a new anti-HCV treatment.
Publisher: Maad Rayan Publishing Company
Date: 2023
Publisher: DoNotEdit
Date: 05-01-2014
DOI: 10.5812/IRCMJ.13247
Publisher: Wiley
Date: 03-2023
DOI: 10.1002/HSR2.1145
Abstract: Chronic obstructive pulmonary disease (COPD) is a common disease of the lungs known as the third reason for death worldwide. Frequent COPD exacerbations compel health care workers to apply interventions that are not adverse effect free. Accordingly, adding or replacing Curcumin, a natural meal flavoring, may indicate advantages in this era by its antiproliferative and anti‐inflammatory effects. The PRISMA checklist was employed for the systematic review study. On June 3, 2022, PubMed/Medline, Scopus, and Web of Science were searched for studies associated with COPD and Curcumin in the last 10 years. Duplicate or non‐English publications and articles with irrelevant titles and abstracts were excluded. Also, preprints, reviews, short communications, editorials, letters to the editor, comments, conference abstracts, and conference papers were not included. Overall, 4288 publications were found eligible, after the screening, 9 articles were finally included. Among them, one, four, and four in vitro, in vivo, and both in vivo and in vitro research exist respectively. According to the investigations, Curcumin can inhibit alveolar epithelial thickness and proliferation, lessen the inflammatory response, remodel the airway, produce ROS, alleviate airway inflammation, hinder emphysema and prevent ischemic complications. Consequently, the findings of the current review demonstrate that Curcumin's modulatory effects on oxidative stress, cell viability, and gene expression could be helpful in COPD management. However, for data confirmation, further randomized clinical trials are required.
Publisher: Briefland
Date: 22-04-2012
DOI: 10.5812/AAPM.4514
Publisher: Informa UK Limited
Date: 07-2011
DOI: 10.2147/OPTH.S21409
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 10-2012
Publisher: Briefland
Date: 25-05-2016
Publisher: Briefland
Date: 1970
Publisher: Briefland
Date: 23-01-2013
DOI: 10.5812/AAPM.14618
Publisher: Springer Science and Business Media LLC
Date: 15-04-2014
DOI: 10.1007/S10103-014-1576-6
Abstract: Osteoarthritis (OA) is one of the most common joint disorders in the elderly which could be associated with considerable physical disability. In a descriptive, prospective study, 33 patients enrolled in the study from which 15 people were excluded due to incomplete course of treatment, leaving the total number of 18 patients with knee osteoarthritis. Gal-Al-As diode laser device was used as a source of low-power laser. Patients were performed laser therapy with a probe of LO7 with a wavelength of 810 nm and 50 mW output power in pulse radiation mode (F = 3,000, peak power = 80 W, Δt = 200 ns, density = 0.05 W/cm(2), dose = 6 J/cm(2), area = 1 cm(2)) and also a probe of MLO1K with a power output of 30 mW and a wavelength of 890 nm in pulse radiation mode (F = 3,000 Hz, peak power = 50 W, Δt = 200 ns, density = 0.017 W/cm(2), total dose = 10 J/cm(2)), and were given low-level laser therapy (LLLT) three times a week with a total number of 12 sessions. Data were analyzed using SPSS ver. 15, and the obtained data were reported as mean ± SD and frequency (%). To analyze the data, repeated measurement and marginal homogeneity approaches were used. In the current study, a significant reduction was observed regarding the nocturnal pain, pain on walking and ascending the steps, knee circumference, distance between the hip and heel, and knee to horizontal hip to heel distance at the end of the treatment course. In brief, the current study focuses on the fact that LLLT is effective in reducing pain in knee osteoarthritis.
Publisher: World Health Organization Regional Office for the Eastern Mediterranean (WHO/EMRO)
Date: 02-2012
Abstract: The anaesthetic agent halothane is still widely used in developing countries including the Islamic Republic of Iran because of its low price. Because of halothane-induced hepatitis, a rare complication, it has been replaced by other inhalation anaesthetics in Western countries it has been suggested by some Iranian professionals that the Islamic Republic of Iran should do the same. We evaluated various dimensions of this replacement through a literature review to assess the incidence of halothane-induced hepatitis and costs of anaesthetics in the country. We also conducted a questionnaire survey of 30 anaesthesiology/gastroenterology experts about their views on the subject. The results indicate that the incidence of halothane hepatitis in the Islamic Republic of Iran is very low and could mostly be avoided by strict adherence to guidelines. Complete withdrawal of halothane in the Islamic Republic of Iran might not be appropriate at present. Comprehensive cost-effectiveness studies are needed before a decision is made on complete replacement of halothane with other anaesthetics.
Publisher: Briefland
Date: 26-11-2022
DOI: 10.5812/PMCO-132037
Publisher: Briefland
Date: 15-02-2014
DOI: 10.5812/AAPM.15444
Publisher: Elsevier BV
Date: 06-2019
Publisher: DoNotEdit
Date: 05-02-2014
DOI: 10.5812/IRCMJ.13938
Publisher: Briefland
Date: 25-10-2012
Publisher: SAGE Publications
Date: 06-2014
Publisher: Emerald
Date: 14-06-2023
Abstract: Coronavirus disease-2019 (COVID-19) is becoming a crucial health problem worldwide. Continued and high-speed mutations of this virus result in the appearance of new manifestations, making the control of this disease difficult. It has been shown that well-nourished patients have strong immune systems who mostly have short-term hospitalization compared to others. The purpose of this study is to review the major nutrients involved in the immune system reinforcement and to explain nutritional aspects during the recovery of COVID-19. In this review paper, the mechanistic role of nutrients in boosting the immune system and the nutritional aspects during the recovery of COVID-19 patients were discussed. Papers indexed in scientific databases were searched using antioxidants, COVID-19, inflammation, immune system, macronutrient, micronutrient and probiotic as keywords from 2000 to 2022. Because of the adverse effects of drugs like thrombosis, pulmonary embolism and hypercholesterolemia, a balanced diet with enough concentrations of energy and macronutrients could increase the patient's durability. The inflammatory cytokines in a vicious cycle delay patients’ rehabilitation. The main mechanistic roles of micronutrients are attributed to the downregulation of virus replication and are involved in energy homeostasis. Dysbiosis is defined as another disturbance among COVID-19 patients, and supplementation with beneficial strains of probiotics helps to exert anti-inflammatory effects in this regard. Being on a well-planned diet with anti-inflammatory properties could reverse cytokine storms as the major feature of COVID-19. Future studies are needed to determine the safe and effective dose of dietary factors to control the COVID-19 patients. Being on a well-planned diet with anti-inflammatory properties could reverse cytokine storms as the major feature of COVID-19. Future studies are needed to determine the safe and effective dose of dietary factors to control the COVID-19 patients.
Publisher: Kowsar Medical Institute
Date: 2013
Publisher: Kowsar Medical Institute
Date: 2013
Publisher: Briefland
Date: 12-07-2012
DOI: 10.5812/AAPM.4526
Publisher: Hindawi Limited
Date: 14-06-2020
DOI: 10.1111/IJCP.13557
Publisher: Briefland
Date: 30-11-2015
DOI: 10.5812/AAPM.29698
Publisher: Briefland
Date: 22-04-2012
DOI: 10.5812/AAPM.4529
Publisher: Briefland
Date: 07-2013
DOI: 10.5812/AAPM.9653
Publisher: Briefland
Date: 22-04-2012
DOI: 10.5812/AAPM.4523
Publisher: Elsevier BV
Date: 11-2021
DOI: 10.1016/J.MSARD.2021.103256
Abstract: This systematic review and meta-analysis aims to evaluate efficacy of deep brain stimulation (DBS) in treating MS-related tremor. We systematically searched PubMed, Web of Science, Embase, Scopus, Google Scholar, and gray literature using a search strategy including the MeSH and text words as (((Brain Stimulations) OR (Deep Brain Stimulations) OR (Deep Brain Stimulations) OR (Deep Brain Brain Stimulation) OR (Deep Electrical Stimulation of the Brain)) AND (Multiple Sclerosis OR Sclerosis, Multiple) OR Sclerosis, Disseminated) OR Disseminated Sclerosis) OR MS (Multiple Sclerosis)) OR Multiple Sclerosis, Acute Fulminating). The literature search revealed 1663 articles, 1027 of which remained after removing duplicates. Seventeen articles, published between 1999-2018, were included for the meta-analysis, including overall 168 patients. Follow-up time ranged between 6-62 months. The pooled frequency of tremor improvement among the enrolled patients was 73%, (95% CI:64-83%) (I The results of this systematic review and meta-analysis demonstrate MS-related tremor improvement after DBS.
Publisher: Briefland
Date: 2011
Publisher: Briefland
Date: 06-03-2016
Publisher: Frontiers Media SA
Date: 2013
Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignant diseases and has the fourth highest mortality rate worldwide. Chronic hepatitis B virus (HBV) infection has been identified as a major risk factor in HCC. Currently available evidence support a critical role of hepatitis B virus x (HBx) gene and protein in the pathogenesis of HBV-induced HCC. HBx protein is a multifunctional regulator that modulates cellular signal transduction pathways, transcriptional regulations, cell cycle progress, DNA repair, apoptosis, and genetic stability by interacting with different host factors. This review describes the current state of knowledge about the biological roles of this protein in the development of HCC.
Publisher: Wiley
Date: 09-10-2012
DOI: 10.1111/JVH.12006
Abstract: Hepatitis C virus (HCV) infection remains a major cause of chronic liver disease with an estimated 170 million carriers worldwide. Current treatments have significant side effects and have met with only partial success. Therefore, alternative antiviral drugs that efficiently block virus production are needed. During recent decades, RNA interference (RNAi) technology has not only become a powerful tool for functional genomics but also represents a new therapeutic approach for treating human diseases including viral infections. RNAi is a sequence-specific and post-transcriptional gene silencing process mediated by double-stranded RNA (dsRNA). As the HCV genome is a single-stranded RNA that functions as both a messenger RNA (mRNA) and replication template, it is an attractive target for the study of RNAi-based viral therapies. In this review, we will give a brief overview about the history and current status of RNAi and focus on its potential application as a therapeutic option for treatment for HCV infection.
Publisher: CMB Association
Date: 30-06-2016
Publisher: Briefland
Date: 11-10-2014
Publisher: Elsevier BV
Date: 09-2014
DOI: 10.1016/J.JCLINANE.2014.03.011
Abstract: A patient with refractory trigeminal neuralgia (tic douloureux) was treated by intravenous magnesium sulfate successfully. Parenteral magnesium sulfate is an analgesic that expresses its analgesic effects through a noncompetitive blockade of the N-methyl-D-aspartate (NMDA) receptors, which in turns inhibits calcium entry into the cells.
Publisher: Cold Spring Harbor Laboratory
Date: 06-02-2021
DOI: 10.1101/2021.02.04.21251143
Abstract: Early prediction of symptoms and mortality risks for COVID-19 patients would improve healthcare outcomes, allow for the appropriate distribution of healthcare resources, reduce healthcare costs, aid in vaccine prioritization and self-isolation strategies, and thus reduce the prevalence of the disease. Such publicly accessible prediction models are lacking, however. Based on a comprehensive evaluation of existing machine learning (ML) methods, we created two models based solely on the age, gender, and medical histories of 23,749 hospital-confirmed COVID-19 patients from February to September 2020: a symptom prediction model (SPM) and a mortality prediction model (MPM). The SPM predicts 12 symptom groups for each patient: respiratory distress, consciousness disorders, chest pain, paresis or paralysis, cough, fever or chill, gastrointestinal symptoms, sore throat, headache, vertigo, loss of smell or taste, and muscular pain or fatigue. The MPM predicts the death of COVID-19-positive in iduals. The SPM yielded ROC-AUCs of 0.53-0.78 for symptoms. The most accurate prediction was for consciousness disorders at a sensitivity of 74% and a specificity of 70%. 2440 deaths were observed in the study population. MPM had a ROC-AUC of 0.79 and could predict mortality with a sensitivity of 75% and a specificity of 70%. About 90% of deaths occurred in the top 21 percentile of risk groups. To allow patients and clinicians to use these models easily, we created a freely accessible online interface at www.aicovid.org . The ML models predict COVID-19-related symptoms and mortality using information that is readily available to patients as well as clinicians. Thus, both can rapidly estimate the severity of the disease, allowing shared and better healthcare decisions with regard to hospitalization, self-isolation strategy, and COVID-19 vaccine prioritization in the coming months.
Publisher: Briefland
Date: 10-10-2015
Publisher: Briefland
Date: 08-07-2014
DOI: 10.5812/AAPM.19407
Publisher: Medknow
Date: 2011
Publisher: Briefland
Date: 27-12-2017
DOI: 10.5812/AAPM.64557
Publisher: Briefland
Date: 18-11-2012
DOI: 10.5812/AAPM.8583
Publisher: Briefland
Date: 07-01-2015
DOI: 10.5812/AAPM.23409
Publisher: Kowsar Medical Institute
Date: 04-04-2012
Publisher: Briefland
Date: 24-02-2015
DOI: 10.5812/AAPM.23923
Publisher: Briefland
Date: 31-01-2016
DOI: 10.5812/AAPM.33849
Publisher: Briefland
Date: 2011
Publisher: Springer Science and Business Media LLC
Date: 05-09-2022
DOI: 10.1007/S10072-022-06364-6
Abstract: The prevalence of restless legs syndrome (RLS) is reported to vary in patients with multiple sclerosis (MS) in studies which are conducted in different populations. The goal of this systematic review and meta-analysis is to update the prevalence of RLS in MS cases. We searched PubMed, Scopus, EMBASE, CINAHL, Web of Science, Google Scholar, and gray literature including references from identified studies and conference abstracts which were published up to June 2021. Data on the total number of participants, first author, country, disease duration, number of controls, mean patient age, male and female numbers, mean EDSS, and number of cases and/or controls with RLS were extracted from the included studies. The literature search revealed 855 articles after deleting duplicates, 530 remained. For the meta-analysis, 75 studies were included (Fig. 1). In six articles, the authors did not differentiate between CIS and MS cases when reporting RLS cases. In total, 15,411 MS/CIS patients were evaluated and 4309 had RLS. The pooled prevalence of RLS was 28% (95% CI: 24-33%). The pooled prevalence of RLS in men was 22% (95% CI: 17-26%), and the pooled prevalence of RLS in women was 30% (95% CI: 25-35%). The pooled prevalence of RLS in controls was 8% (95% CI: 6-10%). The results of this systematic review and meta-analysis show that the pooled prevalence of RLS is 28% in MS cases and 8%. The pooled prevalence is higher in women than men (30% vs 22%).
Publisher: Academic World Research
Date: 30-10-2020
Publisher: Briefland
Date: 25-11-2013
DOI: 10.5812/AAPM.6442
Publisher: Elsevier BV
Date: 11-2011
DOI: 10.1016/J.IJPHARM.2011.08.050
Abstract: In gene therapy of pancreatic cancer, non-viral vectors show an important role. These vectors are modified with the aim of improvement for pancreatic cancer gene therapy. For this aim, we used N,N-diethyl N-methyl chitosan (DEMC) for gene delivery to human pancreatic cancer cells (AsPC-1). pEGFP (Enhanced green fluorescent protein plasmid) was used as a model plasmid. In order to evaluate the efficiency of this polymer for gene delivery, the DEMC EGFP complexes are characterized via photon correlation spectroscopy, gel electrophoresis, fluorescence microscopy, flow cytometry and MTT assay. Also cancer cells' mean fluorescence intensity (MFI) and size changes after transfection are evaluated. The enhancement in polyplexes' charge ratios from 5 to 40, results in 16.70-fold increase in transfection efficiency. Higher MFI, cell size and cytotoxicity were observed as the N/P ratio increased. Considering that mathematical models can be used to understand and predict consequences associated with nanomedicine, the relation between DEMC DNA complexes charge ratio, cell transfection and toxicity was evaluated for the first time with Lagrange's interpolation polynomial method.
Publisher: Briefland
Date: 13-02-2016
DOI: 10.5812/AAPM.35506
Publisher: Briefland
Date: 2011
Publisher: Briefland
Date: 07-2012
DOI: 10.5812/AAPM.4300
Publisher: Briefland
Date: 13-09-2012
DOI: 10.5812/AAPM.4301
Publisher: Briefland
Date: 2011
Publisher: Wiley
Date: 05-2010
DOI: 10.1111/J.1365-2893.2010.01284.X
Abstract: More than two billion people have been infected with hepatitis B virus (HBV). Globally, 350-400 million suffer from chronic HBV infection. It is postulated that dentists and dental staff are infected and transmit the virus to their patients more than any other occupation. The aim of this article is to review the HBV incidence in dental society, the points of view of dentists and their patients regarding transmission of the virus during dental procedures, the occurrence of HBV outbreaks in dental clinics and the importance of methods of preventing HBV infection in dentistry.
Publisher: Springer Science and Business Media LLC
Date: 17-11-2021
Publisher: DoNotEdit
Date: 05-07-2014
DOI: 10.5812/IRCMJ.17497
Publisher: Medknow
Date: 2018
Publisher: DoNotEdit
Date: 05-02-2014
DOI: 10.5812/IRCMJ.13326
Publisher: Briefland
Date: 27-04-2016
DOI: 10.5812/AAPM.26749
Publisher: Briefland
Date: 27-03-2022
DOI: 10.5812/PMCO.123945
Publisher: Maad Rayan Publishing Company
Date: 30-12-2020
Publisher: Clinics Cardive Publishing
Date: 20-04-2012
Publisher: Briefland
Date: 25-10-2012
DOI: 10.5812/JCP.9015
Location: Iran (Islamic Republic of)
Location: Iran (Islamic Republic of)
Location: Iran (Islamic Republic of)
Location: Iran (Islamic Republic of)
No related grants have been discovered for Saeid Safari.