ORCID Profile
0000-0002-1604-1945
Current Organisations
Ruprecht Karls Universität Heidelberg
,
Heidelberg University
,
University of Jyväskylä
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Publisher: Cold Spring Harbor Laboratory
Date: 31-03-2019
DOI: 10.1101/594457
Abstract: Adult lung function is highly heritable and 279 genetic loci were recently reported as associated with spirometry-based measures of lung function. Though lung development and function differ between males and females throughout life, there has been no genome-wide study to identify genetic variants with differential effects on lung function in males and females. Here, we present the first genome-wide genotype-by-sex interaction study on four lung function traits in 303,612 participants from the UK Biobank. We detected five SNPs showing genome-wide significant (P × 10 −8 ) interactions with sex on lung function, as well as 21 suggestively significant interactions (P × 10 −6 ). The strongest sex interaction signal came from rs7697189 at 4:145436894 on forced expiratory volume in 1 second (FEV 1 ) (P = 3.15 × 10 −15 ), and was replicated (P = 0.016) in 75,696 in iduals in the SpiroMeta consortium. Sex-stratified analyses demonstrated that the minor (C) allele of rs7697189 increased lung function to a greater extent in males than females (untransformed FEV 1 β = 0.028 [SE 0.0022] litres in males vs β = 0.009 [SE 0.0014] litres in females), and this effect was not accounted for by differential effects on height, smoking or age at puberty. This SNP resides upstream of the gene encoding hedgehog-interacting protein ( HHIP ) and has previously been reported for association with lung function and HHIP expression in lung tissue. In our analyses, while HHIP expression in lung tissue was significantly different between the sexes with females having higher expression (most significant probeset P=6.90 × 10 −6 ) after adjusting for age and smoking, rs7697189 did not demonstrate sex differential effects on expression. Establishing the mechanism by which HHIP SNPs have different effects on lung function in males and females will be important for our understanding of lung health and diseases, such as chronic obstructive pulmonary disease (COPD), in both sexes.
Publisher: Springer Science and Business Media LLC
Date: 24-01-2020
DOI: 10.1186/S11556-020-0237-Y
Abstract: Physical activity is crucial to maintain older adults’ health and functioning, but the health benefits of particular activity intensities remain unclear. The aim of this cross-sectional study was to peruse the distribution of physical activity, and to investigate the associations of particular physical activity intensities with body composition and physical function among older adults. The s le comprised of 293 community-dwelling sedentary or at most moderately active older adults (42% men, mean age 74 ± 4 years). Physical activity was measured with a hip-worn tri-axial accelerometer over seven consecutive days, and investigated in detailed intensity range and in categories of sedentary, light and moderate-to-vigorous activity. Fat percent and appendicular lean mass were measured with DXA. Physical function was assessed by six-minutes walking test (6-min walk), maximal walking speed over 10 m (10-m walk) and Short Physical Performance Battery (SPPB). Associations were estimated with partial correlation adjusted for sex and age. Participants spent on average 602 min per day sedentary, 210 min in light activity and 32 min in moderate-to-vigorous activity. Light and moderate-to-vigorous activity were negatively associated with fat percent ( r = − 0.360 and r = − 0.384, respectively, p 0.001 for both), and positively with SPPB, 10-m walk and 6-min walk results ( r = 0.145–0.279, p 0.01, for light and r = 0.220–0.465, p 0.001, for moderate-to-vigorous activity). In detailed investigation of the intensity range, associations of physical activity with fat percent, 6-min walk and 10-m walk were statistically significant from very light intensity activity onward, whereas significant associations between physical activity and SPPB were observed mostly at higher end of the intensity range. Sedentary time was positively associated with fat percent ( r = 0.251, p 0.001) and negatively with 6-min walk ( r = − 0.170, p 0.01). Perusing the physical activity intensity range revealed that, among community-dwelling sedentary or at most moderately active older adults, physical activity of any intensity was positively associated with lower fat percent and higher walking speed over long and short distances. These findings provide additional evidence of the importance of encouraging older adults to engage in physical activity of any intensity. More intervention studies are required to confirm the health benefits of light-intensity activity.
Publisher: MDPI AG
Date: 10-09-2021
DOI: 10.3390/S21186068
Abstract: (1) Background: The purpose of this study was to evaluate the day-to-day variability and year-to-year reproducibility of an accelerometer-based algorithm for sit-to-stand (STS) transitions in a free-living environment among community-dwelling older adults. (2) Methods: Free-living thigh-worn accelerometry was recorded for three to seven days in 86 (women n = 55) community-dwelling older adults, on two occasions separated by one year, to evaluate the long-term consistency of free-living behavior. (3) Results: Year-to-year intraclass correlation coefficients (ICC) for the number of STS transitions were 0.79 (95% confidence interval, 0.70–0.86, p 0.001), for mean angular velocity—0.81 (95% ci, 0.72–0.87, p 0.001), and maximal angular velocity—0.73 (95% ci, 0.61–0.82, p 0.001), respectively. Day-to-day ICCs were 0.63–0.72 for number of STS transitions (95% ci, 0.49–0.81, p 0.001) and for mean angular velocity—0.75–0.80 (95% ci, 0.64–0.87, p 0.001). Minimum detectable change (MDC) was 20.1 transitions/day for volume, 9.7°/s for mean intensity, and 31.7°/s for maximal intensity. (4) Conclusions: The volume and intensity of STS transitions monitored by a thigh-worn accelerometer and a sit-to-stand transitions algorithm are reproducible from day to day and year to year. The accelerometer can be used to reliably study STS transitions in free-living environments, which could add value to identifying in iduals at increased risk for functional disability.
Publisher: F1000 Research Ltd
Date: 12-01-2018
DOI: 10.12688/WELLCOMEOPENRES.12583.1
Abstract: Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV 1 ), forced vital capacity (FVC) and the ratio of FEV 1 to FVC (FEV 1 /FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 in iduals of European ancestry from 23 studies, and 7,721 in iduals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent in iduals. Results: We identified significant (P ·8x10 -7 ) associations with six SNPs: a nonsynonymous variant in RPAP1 , which is predicted to be damaging, three intronic SNPs ( SEC24C, CASC17 and UQCC1 ) and two intergenic SNPs near to LY86 and FGF10. Expression quantitative trait loci analyses found evidence for regulation of gene expression at three signals and implicated several genes, including TYRO3 and PLAU . Conclusions: Further interrogation of these loci could provide greater understanding of the determinants of lung function and pulmonary disease.
Publisher: Oxford University Press (OUP)
Date: 29-07-2020
Abstract: In old age, decline in functioning may cause changes in walking ability. Our aim was to study whether older people who report adaptive, maladaptive, or no walking modifications differ in outdoor mobility. Community-dwelling people aged 75–90 years (N = 848) were interviewed at baseline, of whom 761 participated in the 2-year follow-up. Walking modifications were assessed by asking the participants whether they had modified their way of walking 2 km due to their health. Based on the responses, three categories were formed: no walking modifications (reference), adaptive (eg, walking more slowly, using an aid), and maladaptive walking modifications (reduced frequency of walking, or having given up walking 2 km). Differences between these categories in life-space mobility, autonomy in participation outdoors, and unmet physical activity need were analyzed using generalized estimation equation models. Participants with maladaptive walking modifications (n = 238) reported the most restricted life-space mobility (β = −9.6, SE = 2.5, p .001) and autonomy in participation outdoors (β = 1.7, SE = 0.6, p = .004) and the highest prevalence of unmet physical activity need (odds ratio = 4.3, 95% confidence interval = 1.1–16.5) at baseline and showed a decline in these variables over time. Those with no walking modifications (n = 285) at baseline exhibited the best values in all outdoor mobility variables and no change over time. Although at baseline those with adaptive walking modifications (n = 325) resembled those with no modifications, their outdoor mobility declined over time. Adopting adaptive modifications may postpone decline in outdoor mobility, whereas the use of maladaptive modifications has unfavorable consequences for outdoor mobility.
Publisher: Springer Science and Business Media LLC
Date: 07-01-2019
Publisher: European Respiratory Society (ERS)
Date: 05-12-2013
DOI: 10.1183/09031936.00046213
Abstract: Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interin idual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according to the Global Lungs Initiative (GLI) criteria (or 1189 COPD cases according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria), 2834 asthma cases with 28 195 controls, and spirometric parameters (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC) of 12 595 in iduals. Associations with telomere length were tested by linear regression, adjusting for age, sex and smoking status. We observed negative associations between telomere length and asthma (β= -0.0452, p=0.024) as well as COPD (β= -0.0982, p=0.001), with associations being stronger and more significant when using GLI criteria than those of GOLD. In both diseases, effects were stronger in females than males. The investigation of spirometric indices showed positive associations between telomere length and FEV1 (p=1.07×10(-7)), FVC (p=2.07×10(-5)), and FEV1/FVC (p=5.27×10(-3)). The effect was somewhat weaker in apparently healthy subjects than in COPD or asthma patients. Our results provide indirect evidence for the hypothesis that cellular senescence may contribute to the pathogenesis of COPD and asthma, and that lung function may reflect biological ageing primarily due to intrinsic processes, which are likely to be aggravated in lung diseases.
Publisher: Oxford University Press (OUP)
Date: 02-07-2020
Abstract: Fatigue related to task standardized by duration and intensity, termed fatigability, could manifest as shortening of activity bouts throughout the day causing daily activity to accumulate in a more fragmented pattern. Our purpose was to study the association of activity fragmentation with physical and mental dimensions of fatigability. A cross-sectional study of 485 community-dwelling 75-, 80-, and 85-year-old people using a thigh-worn accelerometer for 3–7 days. Activity fragmentation was studied as Active-to-Sedentary Transition Probability for 2 operational definitions of physical activity: accelerations equivalent to at least light physical activity and for upright posture. Physical fatigability was assessed as perceived exertion fatigability, performance fatigability severity, and with the Physical Fatigue Subscale of the Situational Fatigue Scale. Mental fatigability was assessed with the Mental Fatigue Subscale of the Situational Fatigue Scale and as a decrease in perceived mental alertness after a 6-minute walk test. Higher activity fragmentation was associated with higher self-reported physical fatigability, perceived exertion fatigability, and performance fatigability severity, independent of total activity minutes (β = 0.13–0.33, p & .05 for all). Higher activity fragmentation was not associated with mental fatigability in the fully adjusted models. The associations with fatigability indices were similar for both activity fragmentation indicators. Associations of activity fragmentation and performance fatigability severity were similar also among those with the highest intensity-based physical activity volume. The findings provide support that studying fragmented activity patterns can be useful in identifying those at risk for high fatigability, even among those with relatively high physical activity level.
Publisher: Springer Science and Business Media LLC
Date: 06-04-2016
DOI: 10.1038/NCOMMS11008
Abstract: Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry in iduals, we identify six novel loci ( FAM150B-ACP1 , LINC00340 , FBN1 , DIS3L-MAP2K1 , ARID2-SNAT1 and SLC14A2 ) associated with refractive error. In Asian populations, three genome-wide significant loci AREG , GABRR1 and PDE10A also exhibit strong interactions with education ( P .5 × 10 −5 ), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.
Publisher: Oxford University Press (OUP)
Date: 07-06-2020
Abstract: Walking forms a large portion of physical activity (PA) of older adults. We assessed free-living PA using acceleration corresponding to preferred walking speed as a relative cut-point and studied how it relates to age. We compared the relative cut-point to a common absolute cut-point of moderate-to-vigorous physical activity (MVPA). Four hundred forty-four community-dwelling adults aged 75, 80, and 85 years wore an accelerometer on the thigh during a PA surveillance period and a modified 6-minute walking test (6MWT) at preferred speed. Each in idual’s mean acceleration (g) during the 6MWT was used as a cut-point for relative PA. Acceleration corresponding to three metabolic equivalents (METs) was used as the cut-point for absolute MVPA. When using the acceleration of preferred walking speed as a cut-point, 62 (SD 82) minutes a week of relative PA was detected, compared to 228 (163) minutes of absolute MVPA. For 96% of the participants, the acceleration generated by their preferred walking speed exceeded the common absolute cut-point for MVPA. Absolute MVPA was lower in the older age groups, and 6MWT speed explained 22% of its variation (p & .001), whereas relative PA was independent of walking speed and age. Preferred walking speed was a significant contributor to absolute MVPA and those who walked the slowest accumulated the least MVPA. Assessing relative PA using the intensity of preferred walking speed as a cut-point eliminated the dependency of PA on age and walking speed, and may be a feasible scaling option to evaluate relative PA among older people.
Publisher: Oxford University Press (OUP)
Date: 30-05-2023
Abstract: The Square Kilometre Array Observatory (SKAO) will explore the radio sky to new depths in order to conduct transformational science. SKAO data products made available to astronomers will be correspondingly large and complex, requiring the application of advanced analysis techniques to extract key science findings. To this end, SKAO is conducting a series of Science Data Challenges, each designed to familiarize the scientific community with SKAO data and to drive the development of new analysis techniques. We present the results from Science Data Challenge 2 (SDC2), which invited participants to find and characterize 233 245 neutral hydrogen (H i) sources in a simulated data product representing a 2000 h SKA-Mid spectral line observation from redshifts 0.25–0.5. Through the generous support of eight international supercomputing facilities, participants were able to undertake the Challenge using dedicated computational resources. Alongside the main challenge, ‘reproducibility awards’ were made in recognition of those pipelines which demonstrated Open Science best practice. The Challenge saw over 100 participants develop a range of new and existing techniques, with results that highlight the strengths of multidisciplinary and collaborative effort. The winning strategy – which combined predictions from two independent machine learning techniques to yield a 20 per cent improvement in overall performance – underscores one of the main Challenge outcomes: that of method complementarity. It is likely that the combination of methods in a so-called ensemble approach will be key to exploiting very large astronomical data sets.
Publisher: Springer Science and Business Media LLC
Date: 28-05-2018
Publisher: Public Library of Science (PLoS)
Date: 02-02-2016
Publisher: Springer Science and Business Media LLC
Date: 27-11-2019
DOI: 10.1186/S12889-019-7869-8
Abstract: The current study aims to compare correlations between a range of measures of physical performance and physical activity assessing the same underlying construct in different settings, that is, in a home versus a highly standardized setting of the research center or accelerometer recording. We also evaluated the selective attrition of participants related to these different settings and how selective attrition affects the associations between variables and indicators of health, functioning and overall activity. Cross-sectional analyses comprising population-based s les of people aged 75, 80, and 85 years living independently in Jyväskylä, Finland. The AGNES study protocol involved the following phases: 1) phone interview ( n = 1886), 2) face-to-face at-home interview ( n = 1018), 3) assessments in the research center ( n = 910), and 4) accelerometry ( n = 496). Phase 2 and 3 included walking and handgrip strength tests, and phase 4 a chest-worn and thigh-worn accelerometer estimating physical activity and assessing posture, respectively, for 3–10 days in free-living conditions. Older people with poorer health and functioning more likely refrained from subsequent study phases, each requiring more effort or commitment from participants. Paired measures of walking speed (R = 0.69), handgrip strength (R = 0.85), time in physical activity of at least moderate intensity (R = 0.42), and time in upright posture (R = 0.30) assessed in different settings correlated with each other, and they correlated with indicators of health, functioning and overall activity. Associations were robust regardless of limitations in health and functioning, and low overall activity. Correlational analyses did not clearly reveal one superior setting for assessing physical performance or physical activity. Inclusion of older people with early declines in health, functioning and overall activity in studies on physical performance and physical activity is feasible in terms of study outcomes, but challenging for recruitment.
Publisher: Springer Science and Business Media LLC
Date: 15-06-2014
DOI: 10.1038/NG.3011
Publisher: F1000 Research Ltd
Date: 06-2020
DOI: 10.12688/WELLCOMEOPENRES.15846.1
Abstract: Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent in iduals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P x10 -8 ) interactions with sex on lung function, and 21 showed suggestive interactions (P x10 -6 ). The strongest signal, from rs7697189 (chr4:145436894) on forced expiratory volume in 1 second (FEV 1 ) (P=3.15x10 -15 ), was replicated (P=0.016) in SpiroMeta. The C allele increased FEV 1 more in males (untransformed FEV 1 β=0.028 [SE 0.0022] litres) than females (β=0.009 [SE 0.0014] litres), and this effect was not accounted for by differential effects on height, smoking or pubertal age. rs7697189 resides upstream of the hedgehog-interacting protein ( HHIP ) gene and was previously associated with lung function and HHIP lung expression. We found HHIP expression was significantly different between the sexes (P=6.90x10 -6 ), but we could not detect sex differential effects of rs7697189 on expression. Conclusions: We identified a novel genotype-by-sex interaction at a putative enhancer region upstream of the HHIP gene. Establishing the mechanism by which HHIP SNPs have different effects on lung function in males and females will be important for our understanding of lung health and diseases in both sexes.
Publisher: F1000 Research Ltd
Date: 24-05-2021
DOI: 10.12688/WELLCOMEOPENRES.15846.2
Abstract: Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent in iduals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P x10 -8 ) interactions with sex on lung function, and 21 showed suggestive interactions (P x10 -6 ). The strongest signal, from rs7697189 (chr4:145436894) on forced expiratory volume in 1 second (FEV 1 ) (P=3.15x10 -15 ), was replicated (P=0.016) in SpiroMeta. The C allele increased FEV 1 more in males (untransformed FEV 1 β=0.028 [SE 0.0022] litres) than females (β=0.009 [SE 0.0014] litres), and this effect was not accounted for by differential effects on height, smoking or pubertal age. rs7697189 resides upstream of the hedgehog-interacting protein ( HHIP ) gene and was previously associated with lung function and HHIP lung expression. We found HHIP expression was significantly different between the sexes (P=6.90x10 -6 ), but we could not detect sex differential effects of rs7697189 on expression. Conclusions: We identified a novel genotype-by-sex interaction at a putative enhancer region upstream of the HHIP gene. Establishing the mechanism by which HHIP SNPs have different effects on lung function in males and females will be important for our understanding of lung health and diseases in both sexes.
Publisher: MDPI AG
Date: 18-05-2020
DOI: 10.3390/S20102858
Abstract: Gait variability observed in step duration is predictive of impending adverse health outcomes among apparently healthy older adults and could potentially be evaluated using wearable sensors (inertial measurement units, IMU). The purpose of the present study was to establish the reliability and concurrent validity of gait variability and complexity evaluated with a waist and an ankle-worn IMU. Seventeen women (age 74.8 (SD 44) years) and 10 men (73.7 (4.1) years) attended two laboratory measurement sessions a week apart. Their stride duration variability was concurrently evaluated based on a continuous 3 min walk using a force plate and a waist- and an ankle-worn IMU. Their gait complexity (multiscale s le entropy) was evaluated from the waist-worn IMU. The force plate indicated excellent stride duration variability reliability (intra-class correlation coefficient, ICC = 0.90), whereas fair to good reliability (ICC = 0.47 to 0.66) was observed from the IMUs. The IMUs exhibited poor to excellent concurrent validity in stride duration variability compared to the force plate (ICC = 0.22 to 0.93). A good to excellent reliability was observed for gait complexity in most coarseness scales (ICC = 0.60 to 0.82). A reasonable congruence with the force plate-measured stride duration variability was observed on many coarseness scales (correlation coefficient = 0.38 to 0.83). In conclusion, waist-worn IMU entropy estimates may provide a feasible indicator of gait variability among community-dwelling ambulatory older adults.
Publisher: Springer Science and Business Media LLC
Date: 05-06-2012
Publisher: Springer Science and Business Media LLC
Date: 03-2023
DOI: 10.1038/S41588-023-01314-0
Abstract: Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. In idual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of intervening in pathways underlying lung function. We highlight new putative causal variants, genes, proteins and pathways, including those targeted by existing drugs. These findings bring us closer to understanding the mechanisms underlying lung function and COPD, and should inform functional genomics experiments and potentially future COPD therapies.
Publisher: SAGE Publications
Date: 28-07-2020
Abstract: Objectives: To examine associations of perceived outdoor environment with the prevalence and development of adaptive (e.g., slower pace) and maladaptive (e.g., avoiding walking) modifications in walking 2 km among older people. Methods: Community-dwelling 75–90 -year-old persons ( N = 848) reported environmental outdoor mobility facilitators and barriers at baseline. Modifications in walking 2 km (adaptive, maladaptive, or no) were assessed at baseline and one and two years later. Results: Outdoor mobility facilitators were more often reported by those not using modifications or using adaptive versus maladaptive walking modifications. Differences in health and physical capacity explained most of the associations between outdoor mobility barriers and walking modifications. Perceived outdoor environment did not systematically predict future adaptive or maladaptive walking modifications. Discussion: Facilitators may compensate the declined physical capacity and alleviate the strain of walking longer distances by enabling the use of adaptive walking modifications, while lack of such facilitators fuels avoidance of walking longer distances.
Publisher: Springer Science and Business Media LLC
Date: 30-03-2011
DOI: 10.1038/EJHG.2011.21
Publisher: SAGE Publications
Date: 10-06-2020
Abstract: Objectives: The aim of this study was to report preplanned secondary analyses of the effects of a 12-month in idualized active aging counseling intervention on six mobility and physical activity outcomes. Methods: A two-arm, single-blinded randomized controlled trial was conducted among 75- and 80-year-old community-dwelling people. The intervention group (IG, n = 101) received counseling aimed at increasing self-selected, primarily out-of-home activity. The control group (CG, n = 103) received general health information. Data were analyzed with generalized estimating equations. Results: Physical performance improved in the IG more than that in the CG (group by time p = .022), self-reported physical activity increased in both groups (time p = .012), and autonomy in outdoor mobility declined in the IG and was enhanced in the CG (group by time p = .011). No change was observed for life-space mobility, proportion of persons perceiving difficulty walking 2 km, or monitored physical activity. Discussion: In idualized counseling aiming at increasing self-selected out-of-home activity had nonsystematic effects on mobility and positively affected physical performance only.
Publisher: Elsevier BV
Date: 10-2019
DOI: 10.1016/J.GAITPOST.2019.08.006
Abstract: Wearable inertial sensors have been shown to provide valid mean gait characteristics assessments, however, assessment of variability is less convincingly established. What level of concurrent validity, and session-to-session reliability does an ankle-worn inertial measurement unit (IMU)-based gait assessment with a novel angular velocity-based gait event detection algorithm have among older adults? Twenty seven (women N = 17) participants volunteered (age 74.4 (SD 4.3) years, body mass 74.5 (12.0) kg, height 165.9 (9.9) cm). Right leg stance, swing, and stride duration and stride length, and stride velocity were concurrently assessed with motion capture and with an IMU from a 3 min self-paced walk up and back a 14 m track repeated twice a week apart. Gait variability was assessed as the SD of all of the registered strides. Significant difference was observed between methods for many of the mean stride characteristics and stride variability (all p < 0.05), fair to excellent agreement was observed for mean values of all of the five stride characteristics evaluated (intra-class correlation coefficient [ICC] from 0.43 to 1.00). However, poor agreement was observed for the SD of all of the evaluated stride characteristics (ICC from -0.25 to 0.00). Both methods indicated excellent session to session reliability for all of the five stride characteristics evaluated (ICC from 0.84 to 0.98, CV% Excellent concurrent validity and reliability was observed for mean spatiotemporal stride characteristics, however, gait variability exhibited poor concurrent validity and reliability. Although IMUs and the presented algorithm could be used to assess mean spatiotemporal stride characteristics among older in iduals, either a more reliable gait event detection algorithm or alternative analytical approaches should be used for gait variability.
Publisher: Cold Spring Harbor Laboratory
Date: 17-07-2017
DOI: 10.1101/164426
Abstract: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease (COPD). We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and the ratio of FEV1 to FVC (FEV1/FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 in iduals of European ancestry from 23 studies, and 7,721 in iduals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent in iduals. We identified significant (P ·8x10 -7 ) associations with six SNPs: a nonsynonymous variant in RPAP1 , which is predicted to be damaging, three intronic SNPs ( SEC24C, CASC17 and UQCC1 ) and two intergenic SNPs near to LY86 and FGF10 . eQTL analyses found evidence for regulation of gene expression at three signals and implicated several genes including TYRO3 and PLAU . Further interrogation of these loci could provide greater understanding of the determinants of lung function and pulmonary disease.
Publisher: BMJ
Date: 09-2019
DOI: 10.1136/BMJOPEN-2019-029682
Abstract: The most promising way to promote active life years in old age is to promote regular participation in physical activity (PA). Maintaining lower extremity muscle function with good balance has been associated with fewer falls and the need of help from others. This article describes the design and intervention of a randomised controlled trial (RCT) investigating the effectiveness of a health and PA counselling programme on life-space mobility and falls rates in community-dwelling older adults at the Health Kiosk and/or Service Centre. Community-dwelling men and women (n=450) aged 65 years and over with early phase mobility limitation will be recruited to a 24-month RCT with a 24-month follow-up. Participants will be randomly allocated into either a health and PA counselling group (intervention) or relaxation group (control intervention). All participants will receive five group specific face-to-face counselling sessions and 11 phone calls. The counselling intervention will include in idualised health counselling, strength and balance training, and guidance to regular PA. The control group will receive relaxation exercises. Outcomes will be assessed at baseline, 12, 24 and 48 months. Primary outcomes are average life-space mobility score and falls rates. Life-space mobility will be assessed by a validated questionnaire. Falls rates will be recorded from fall diaries. Secondary outcomes are data on fall-induced injuries and living arrangements, number of fallers, fracture risk, mean level of PA, physical performance, quality of life, mood, cognition, balance confidence and fear of falling. Data will be analysed using the intention-to-treat principle. Cost-effectiveness of the programme will be analysed. Ancillary analyses are planned in participants with greater adherence. Ethical approval was obtained from the Ethics Committee of the T ere University Hospital (R15160). Outcomes will be disseminated through publication in peer-reviewed journals and presentations at international conferences. ISRCTN65406039 Pre-results.
Publisher: Springer Science and Business Media LLC
Date: 18-04-2017
DOI: 10.1038/TP.2017.73
Abstract: The association between telomere length (TL) dynamics on cognitive performance over the life-course is not well understood. This study meta-analyses observational and causal associations between TL and six cognitive traits, with stratifications on APOE genotype, in a Mendelian Randomization (MR) framework. Twelve European cohorts ( N =17 052 mean age=59.2±8.8 years) provided results for associations between qPCR-measured TL (T/S-ratio scale) and general cognitive function, mini-mental state exam (MMSE), processing speed by digit symbol substitution test (DSST), visuospatial functioning, memory and executive functioning (STROOP). In addition, a genetic risk score (GRS) for TL including seven known genetic variants for TL was calculated, and used in associations with cognitive traits as outcomes in all cohorts. Observational analyses showed that longer telomeres were associated with better scores on DSST ( β =0.051 per s.d.-increase of TL 95% confidence interval (CI): 0.024, 0.077 P =0.0002), and MMSE ( β =0.025 95% CI: 0.002, 0.047 P =0.03), and faster STROOP ( β =−0.053 95% CI: −0.087, −0.018 P =0.003). Effects for DSST were stronger in APOE ɛ4 non-carriers ( β =0.081 95% CI: 0.045, 0.117 P =1.0 × 10 −5 ), whereas carriers performed better in STROOP ( β =−0.074 95% CI: −0.140, −0.009 P =0.03). Causal associations were found for STROOP only ( β =−0.598 per s.d.-increase of TL 95% CI: −1.125, −0.072 P =0.026), with a larger effect in ɛ4-carriers ( β =−0.699 95% CI: −1.330, −0.069 P =0.03). Two-s le replication analyses using CHARGE summary statistics showed causal effects between TL and general cognitive function and DSST, but not with STROOP. In conclusion, we suggest causal effects from longer TL on better cognitive performance, where APOE ɛ4-carriers might be at differential risk.
Publisher: Oxford University Press (OUP)
Date: 03-08-2023
Abstract: We explore how the characteristics of the cross-correlation functions between the 21-cm emission from the spin-flip transition of neutral hydrogen (H $\\scriptstyle \\rm I $) and early Lyman α (Ly α) radiation emitting galaxies (Ly α emitters, LAEs) depend on the reionization history and topology and the simulated volume. For this purpose, we develop an analytic expression for the 21-cm-LAE cross-correlation function and compare it to results derived from different astraeus and 21cmfast reionization simulations covering a physically plausible range of scenarios where either low-mass (≲ 109.5 M⊙) or massive (≳ 109.5 M⊙) galaxies drive reionization. Our key findings are: (i) the negative small-scale (≲ 2 cMpc) cross-correlation litude scales with the intergalactic medium’s (IGM) average H $\\scriptstyle \\rm I $ fraction (〈χH i〉) and spin-temperature weighted overdensity in neutral regions (〈1 + δ〉H i) (ii) the inversion point of the cross-correlation function traces the peak of the size distribution of ionized regions around LAEs (iii) the cross-correlation litude at small scales is sensitive to the reionization topology, with its anticorrelation or correlation decreasing the stronger the ionizing emissivity of the underlying galaxy population is correlated to the cosmic web gas distribution (i.e. the more low-mass galaxies drive reionization) (iv) the required simulation volume to not underpredict the 21-cm-LAE anticorrelation litude when the cross-correlation is derived via the cross-power spectrum rises as the size of ionized regions and their variance increases. Our analytic expression can serve two purposes: to test whether simulation volumes are sufficiently large, and to act as a fitting function when cross-correlating future 21-cm signal Square Kilometre Array and LAE galaxy observations.
Publisher: F1000 Research Ltd
Date: 07-08-2018
DOI: 10.12688/WELLCOMEOPENRES.12583.3
Abstract: Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV 1 ), forced vital capacity (FVC) and the ratio of FEV 1 to FVC (FEV 1 /FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 in iduals of European ancestry from 23 studies, and 7,721 in iduals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent in iduals. Results: We identified significant (P ·8x10 -7 ) associations with six SNPs: a nonsynonymous variant in RPAP1 , which is predicted to be damaging, three intronic SNPs ( SEC24C, CASC17 and UQCC1 ) and two intergenic SNPs near to LY86 and FGF10. Expression quantitative trait loci analyses found evidence for regulation of gene expression at three signals and implicated several genes, including TYRO3 and PLAU . Conclusions: Further interrogation of these loci could provide greater understanding of the determinants of lung function and pulmonary disease.
Publisher: F1000 Research Ltd
Date: 21-06-2018
DOI: 10.12688/WELLCOMEOPENRES.12583.2
Abstract: Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV 1 ), forced vital capacity (FVC) and the ratio of FEV 1 to FVC (FEV 1 /FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 in iduals of European ancestry from 23 studies, and 7,721 in iduals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent in iduals. Results: We identified significant (P ·8x10 -7 ) associations with six SNPs: a nonsynonymous variant in RPAP1 , which is predicted to be damaging, three intronic SNPs ( SEC24C, CASC17 and UQCC1 ) and two intergenic SNPs near to LY86 and FGF10. Expression quantitative trait loci analyses found evidence for regulation of gene expression at three signals and implicated several genes, including TYRO3 and PLAU . Conclusions: Further interrogation of these loci could provide greater understanding of the determinants of lung function and pulmonary disease.
Publisher: Public Library of Science (PLoS)
Date: 20-10-2011
Publisher: Springer Science and Business Media LLC
Date: 04-11-2014
Publisher: Springer Science and Business Media LLC
Date: 30-07-2014
Publisher: Springer Science and Business Media LLC
Date: 02-05-2018
Publisher: Wiley
Date: 24-05-2004
Publisher: MDPI AG
Date: 21-09-2020
Abstract: Accelerometer-derived estimates of physical activity (PA) and sedentary time have been an important methodological focus. However, little is known about the daily activities among older people during their normal lives. Furthermore, some older in iduals would like to be more active, yet experience an unmet PA need, which is defined as the desire to engage in more PA but without the opportunity to act on the desire. This study examined the intensity of daily PA and sedentary behavior measured with accelerometers among older people, and whether PA differs between weekdays and weekends and those with and without the experience of unmet PA need, measured with self-reports. A total of 174 community-dwelling older people (64% female) aged 75 to 90 years used an accelerometer for 7 consecutive days during waking hours, and the results were classified for sedentary behavior (thresholds of 0.0167 g), light activity (0.091 g), and moderate-to-vigorous activity (MVPA, 0.414 g) based on mean litude deviation (g). We found that during weekdays, older people engaged slightly more in light activity and had less sedentary time than during weekends. In total, 7.6% of the participants perceived an unmet PA need. Accordingly, those with unmet PA needs spent less time in MVPA, especially during weekdays, and they might benefit from PA-enabling interventions.
Publisher: Springer Science and Business Media LLC
Date: 13-05-2016
DOI: 10.1038/SREP25853
Abstract: Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) in adults have identified 39 loci associated with refractive error and myopia. Here, the age-of-onset of association between genetic variants at these 39 loci and refractive error was investigated in 5200 children assessed longitudinally across ages 7–15 years, along with gene-environment interactions involving the major environmental risk-factors, nearwork and time outdoors. Specific variants could be categorized as showing evidence of: (a) early-onset effects remaining stable through childhood, (b) early-onset effects that progressed further with increasing age, or (c) onset later in childhood (N = 10, 5 and 11 variants, respectively). A genetic risk score (GRS) for all 39 variants explained 0.6% (P = 6.6E–08) and 2.3% (P = 6.9E–21) of the variance in refractive error at ages 7 and 15, respectively, supporting increased effects from these genetic variants at older ages. Replication in multi-ancestry s les (combined N = 5599) yielded evidence of childhood onset for 6 of 12 variants present in both Asians and Europeans. There was no indication that variant or GRS effects altered depending on time outdoors, however 5 variants showed nominal evidence of interactions with nearwork (top variant, rs7829127 in ZMAT4 P = 6.3E–04).
Publisher: Gerontologia
Date: 09-12-2022
DOI: 10.23989/GERONTOLOGIA.115445
Abstract: Kotona asumista korostavan hoivapolitiikan seurauksena on paljon iäkkäitä henkilöitä, jotka eivät pääse ulos kodistaan ilman apua. Tutkimuksessa tarkastellaan huonokuntoisten iäkkäiden ihmisten ja eläkeikäisten vapaaehtoistyöntekijöiden kokemuksia keskinäisestä kanssakäymisestään vapaaehtoistyöhön perustuvalla toimintajaksolla. Vapaaehtoistyöntekijät auttoivat kodin ulkopuolisiin aktiviteetteihin yksin asuvia iäkkäitä ihmisiä, joilla oli liikkumiskyvyn ongelmia. Tutkimuksessa oli mukana viisi iäkkään ihmisen ja eläkeikäisen vapaaehtoistyöntekijän muodostamaa paria. Tutkimusaineisto koostui iäkkäiden (79–87-vuotiaiden) ihmisten ja vapaaehtoistyöntekijöiden (61–71-vuotiaiden) yksilöhaastatteluista. Aineiston analysointi perustui tulkitsevaan fenomenologiseen analyysiin (Interpretative Phenomenological Analysis, IPA). Analyysin tuloksena aineistosta muodostui viisi pääteemaa, jotka kuvaavat iäkkäiden ihmisten ja vapaaehtoistyöntekijöiden kokemuksia keskinäisestä kanssakäymisestään: itsenäinen arki, auttamisen arvokkuus, vuorovaikutuksen toimivuus, odottamaton onnistuminen ja arjen haasteellisuus. Molemmille osapuolille merkityksellisiä pääteemoja olivat vuorovaikutuksen toimivuus, arjen haasteellisuus ja odottamaton onnistuminen. Lisäksi iäkkäille ihmisille kanssakäymisessä oli merkityksellistä itsenäinen arki ja vapaaehtoistyöntekijöille puolestaan auttamisen arvokkuus. Iäkkäiden ihmisten ja heidän eläkeikäisten toimijapariensa kokemukset kanssakäymisestä vapaaehtoistyössä voidaan ymmärtää molemmille osapuolille merkityksellisenä yhteistoimijuutena. Experiences of elderly in iduals and retirement aged volunteers from their social interaction during voluntary work Because the elderly live at home until late in life, there are many senior citizens who cannot go out without help. The current study investigates the experiences of retirement-aged volunteers and elderly participants during their period of voluntary work-based interaction. The volunteers helped the elderly participants, who lived alone and had difficulty with mobility, to out-of-home activities. Five pairs of volunteer-elderly participants were selected. The data set consists of in idual interviews of the volunteers (aged 61–71 years) and the elderly participants (aged 79–87 years). The data analysis is based on Interpretative Phenomenological Analysis. Five themes describe the experiences the participants had about their interaction: independent everyday life, the value of helping, functioning interaction, unexpected success, and the challenges of everyday life. Both the volunteers and the elderly participants found the interaction as meaningful co-agency. Independent everyday life manifested as meaningful to the elderly participants. The value of helping was central for the volunteers.
No related grants have been discovered for Taina Rantanen.