ORCID Profile
0000-0001-5246-9845
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Analytical Chemistry not elsewhere classified | Pharmacology and Pharmaceutical Sciences | Pharmaceutical Sciences | Macromolecular and Materials Chemistry | Macromolecular and Materials Chemistry not elsewhere classified | Medicinal and Biomolecular Chemistry not elsewhere classified | Chemical Characterisation of Materials
ANZSRC Socio-Economic Objective (SEO)
Instrumentation not elsewhere classified | Expanding Knowledge in the Chemical Sciences | Industrial Instruments | Scientific Instruments | Expanding Knowledge in the Medical and Health Sciences |
Related Links
Publications
Honeycomb Films from Perfluoropolyether-Based Star and Micelle Architectures
Publisher: CSIRO Publishing
Date: 2012
DOI: 10.1071/CH12252
Abstract: A perfluoropolyether-b-poly(t-butyl acrylate) (PFPE-b-PtBA) block copolymer macroinitiator was used to prepare both core cross-linked star (CCS) polymers and micelles, whereby the outer shell and core, respectively, are comprised of fluorinated segments. The star polymer complete with PFPE outer shell was synthesised via atom transfer radical polymerisation (ATRP) and the arm-first approach, through cross-linking of the PFPE-b-PtBA macroinitiator with ethylene glycol diacrylate (EGDA). Alternatively, the PFPE-b-PtBA block copolymer could be self-assembled in benzene to form micelles with a PtBA shell and PFPE core. Both the micelle and CCS polymer were subsequently fabricated into non-cracking honeycomb (HC) patterned films on both planar and non-planar surfaces via the ‘Breath Figure’ (BF) technique using a static casting system.
Peptide-Based Star Polymers: The Rising Star in Functional Polymers
Publisher: CSIRO Publishing
Date: 2012
DOI: 10.1071/CH12251
Abstract: Peptide-based star polymers show great potential as the next-generation of functional polymers due to their structure-related properties. The peptide component augments the polymer’s properties by introducing biocompatible and biodegradable segments, and enhancing their functionalities and structural ordering, which make peptide-based star polymers an attractive candidate in the field of nanomedicine. This article provides a brief summary of the recent developments of peptide-based star polymers synthesised from 2009 onwards. It is evident that the studies conducted so far have only started to uncover the true potential of what these polymers can achieve, and with continued research it is anticipated that peptide-based star polymers will be realised as versatile platforms applicable to broader fields of study, including drug delivery, tissue engineering, biocoatings, bioimaging, and self-directing templating agents.
Combined Fenton and starvation therapies using hemoglobin and glucose oxidase
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8NR09107B
Abstract: Selective cancer treatment using combined Fenton and starvation therapies through hemoglobin and glucose oxidase encapsulated in pH-sensitive ZIF-8.
Highly permeable membrane materials for CO2 capture
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3TA13066E
A novel cross-linked nano-coating for carbon dioxide capture
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5EE02433A
Abstract: Defect-free and cross-linked ultra-thin (sub 100 nm) film composite membranes have been prepared. The membrane materials formed exhibited significantly high CO 2 permeances of over 1200 GPU as well as excellent CO 2 /N 2 selectivity of over 40.
Two-dimensional nanosheet-based gas separation membranes
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TA09070J
Abstract: Two-dimensional nanosheets as building blocks for the preparation of high-performance gas separation membranes.
Autophobicity-Driven Surface Segregation and Patterning of Core−Shell Microgel Nanoparticles
Publisher: American Chemical Society (ACS)
Date: 08-08-2008
DOI: 10.1021/NL802109X
Abstract: Core-shell microgel (CSMG) nanoparticles, also referred to as core-cross-linked star (CCS) polymers, can be envisaged as permanently cross-linked block copolymer micelles and, as such, afford novel opportunities for chemical functionalization, templating, and encapsulation. In this study, we explore the behavior of CSMG nanoparticles comprising a poly(methyl methacrylate) (PMMA) shell in molten PMMA thin films. Because of the autophobicity between the densely packed, short PMMA arms of the CSMG shell and the long PMMA chains in the matrix, the nanoparticles migrate to the film surface. They cannot, however, break through the surface because of the inherently high surface energy of PMMA. Similar thermal treatment of CSMG-containing PMMA thin films with a polystyrene (PS) capping layer replaces surface energy at the PMMA/air interface by interfacial energy at the PMMA/PS interface, which reduces the energy barrier by an order of magnitude, thereby permitting the nanoparticles to emerge out of the PMMA bulk. This nanoscale process is reversible and can be captured at intermediate degrees of completion. Moreover, it is fundamentally general and can be exploited as an alternative means by which to reversibly pattern or functionalize polymer surfaces for applications requiring responsive nanolithography.
Mimicry of silk utilizing synthetic polypeptides
Publisher: Elsevier BV
Date: 07-2202
Highly Ordered Honeycomb Film Formation of Linear Polymers by the Breath Figure Technique
Publisher: CSIRO Publishing
Date: 2016
DOI: 10.1071/CH16119
Abstract: Highly ordered, porous honeycomb (HC) films were prepared by the breath figure technique from linear polymers poly(methyl methacrylate) (PMMA) and polystyrene (PS). Typically HC films are difficult to form from such simple linear polymers. The addition of a novel fluorinated polymer (FP) additive with as little as 1 wt-% to PMMA or 5 wt-% to PS was required to obtain regular porous HC films. Through investigation of the influence of the additive on the polymer properties, three parameters based on interfacial tension, polymer solution viscosity, and polymer solidification rate were identified as key factors affecting the ability of polymer systems to form regular porous HC films. A new hypothesis was subsequently developed based on the relationships of these parameters to explain the unusual behaviour associated with HC film formation from linear PMMA and PS with addition of FP additive. This work will provide a new tool to guide the formation of HC films and will greatly broaden the range of polymers used to form HC films in the future.
The effect of soft nanoparticles morphologies on thin film composite membrane performance
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4TA02859G
Abstract: Novel soft nanoparticles with tunable morphologies were incorporated into thin film composite membrane system for efficient CO 2 capture applications.
Mechanochromophore-Linked Polymeric Materials with Visible Color Changes.
Publisher: Wiley
Date: 11-04-2022
Abstract: Mechanical force as a type of stimuli for smart materials has obtained much attention in the past decade. Color-changing materials in response to mechanical stimuli have shown great potential in the applications such as sensors and displays. Mechanochromophore-linked polymeric materials, which are a growing sub-class of these materials, are discussed in detail in this review. Two main types of mechanochromophores which exhibit visible color change, summarized herein, involve either isomerization or radical generation mechanisms. This review focuses on their synthesis and incorporation into polymer matrices, the type of mechanical force used, factors affecting the mechanochromic properties, and their applications.
Soft nanoparticles assembled from linear poly(ethylene glycol) and linear brush polydimethylsiloxane diblock copolymers
Publisher: Wiley
Date: 18-02-2014
DOI: 10.1002/POLA.27111
Abstract: A series of novel hiphilic diblock copolymers composed of hydrophilic linear poly(ethylene glycol) (PEG) and linear brush hydrophobic polydimethylsiloxane (PDMS) were synthesized. Three different molecular weights of monomethyl ether PEG were initially functionalized with 2‐bromo iso butyryl bromide to afford macroinitiators suitable for atom‐transfer radical polymerization. The macroinitiators were characterized by gel permeation chromatography, 1 H and 13 C nuclear magnetic resonance spectroscopic analysis and matrix‐assisted laser desorption ionization time‐of‐flight mass spectroscopy. The three different molecular weight macroinitiators were then chain extended with monomethacryloxypropyl‐terminated PDMS and photoactive 2‐(methylacyloyloxy)ethyl anthracene‐9‐carboxylate in different molar ratios to afford a series of photoresponsive hiphilic diblock copolymers with high conversions. Self‐assembly of these linear–linear brush diblock copolymers in N , N ‐dimethylformamide afforded nanoparticles with hydrodynamic diameters ( d H ) ranging from 41 to 268 nm, as determined by dynamic light scattering analysis. Crosslinking and stabilization of the nanoparticles was achieved via [4+4] photodimerization of the anthracene moieties upon exposure to UV radiation at 365 nm with the reverse reaction studied at a wavelength of 254 nm. Transmission electron microscopy revealed that the self‐assembled nanoparticles and their crosslinked derivatives had spherical morphologies. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014 , 52 , 1251–1262
Development of novel fluorinated additives for high performance CO2 separation thin-film composite membranes
Publisher: Elsevier BV
Date: 02-2016
Improved Fenton Therapy Using Cancer Cell Hydrogen Peroxide
Publisher: CSIRO Publishing
Date: 2018
DOI: 10.1071/CH18281
Abstract: Fenton cancer therapy as a new methodology for the treatment of tumour cells is largely restricted owing to the low stability, high aggregation, and poor selectivity of reported nanoparticles. In this study, an improved approach for the selective destruction of cancer cells is reported. Metal–organic framework (MOF) nanoparticles were synthesized and reduced via a hydrothermal method, and then PEGylated through the surface-initiated atom transfer radical polymerization (SI-ATRP) reaction to produce a PEGylated reduced MOF (P@rMOF). The ratio of PEG to nanoparticles was used to optimize the size and aggregation of the nanoparticles, with 2P@rMOF (2 : 1 mass ratio) having the smallest hydrodynamic diameter. The nanoparticles were further conjugated with folic acid for cell targeting. In vitro cell uptake experiments demonstrated that the internalization of 2P@rMOF-FA nanoparticles into cancer cells (HeLa) was almost 3-fold that of normal cells (NIH-3T3). In the presence of 2P@rMOF-FA, the HeLa cell viability decreased dramatically to 22 %, whereas the NIH-3T3 cell viability remained higher than 80 % after 24 h incubation. The selectivity index for 2P@rMOF-FA is 4.48, which is significantly higher than those reported in the literature for similar strategies. This work thus demonstrates the most stable and selective nanoparticle system for the treatment of cancer cells using the cell’s own H2O2.
Synthesis and self-assembly of polyimide/poly(dimethylsiloxane) brush triblock copolymers
Publisher: Elsevier BV
Date: 2013
Analysis of thermochromic label elements and colour transitions using sensory acceptability and eye tracking techniques
Publisher: Elsevier BV
Date: 03-2018
Reduced Ice Adhesion Using Amphiphilic Poly(Ionic Liquid)-Based Surfaces
Publisher: American Chemical Society (ACS)
Date: 28-01-2023
Vernetzte Polypeptide durch RAFT‐vermittelte Polymerisation zum kontinuierlichen Aufbau von Polymerfilmen
Publisher: Wiley
Date: 12-01-2022
Abstract: Polypeptidbeschichtungen spielen aufgrund ihres großen biologischen Potentials eine wichtige Rolle in der Oberflächenmodifizierung von Materialien. Da ihre Eigenschaften durch ihren strukturellen Aufbau mitbestimmt werden, ist eine Kontrolle der Struktur durch entsprechende Herstellungsstrategien notwendig. In diesem Artikel berichten wir über eine einfache Methode zur präzisen Herstellung von dicht vernetzten Polypeptidfilmen mit ungewöhnlich hoher β‐Faltblatt – und Zufallsknäuel Konformation durch eine kontinuierliche Assemblierungspolymerisation (CAP, continuous assembly polymerization) mittels reversibler Addtitions‐Fragmentierungs‐Kettenübertragungspolymerisation (RAFT Polymerisation, reversible‐addition‐fragmentation chain‐transfer polymerization), kurz CAP‐RAFT. CAP‐RAFT wurde bereits grundlegend mit methacryliertem Poly‐ l ‐Lysin (PLLMA) und methacrylierter Poly‐ l ‐Glutaminsäure (PLGMA) untersucht. Eine sorgfältige Anpassung der Methode führte hier zu Filmen mit einer Schichtdicke von bis zu 36.1±1.1 nm, die durch mehrfache Anwendung dieser Strategie auf 94.9±8.2 nm erhöht werden konnte. PLLMA‐ und PLGMA‐Filme wiesen überraschenderweise bis zu 30–50 % Zufallsknäuel Konformation auf. Durch den enzymatischen Abbau mit einem Protease‐Mix, der Proteasen im Wundheilungsmileu repräsentiert, konnte das Potential diesen Strukturen für Anwendungen im Wirkstofftransport und in der Gewebezüchtung gezeigt werden.
The behaviour of honeycomb film formation from star polymers with various fluorine content
Publisher: Elsevier BV
Date: 08-2013
Soft polymeric nanoparticle additives for next generation gas separation membranes
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3TA14170E
Crosslinked Polypeptide Films via RAFT-Mediated Continuous Assembly of Polymers.
Publisher: Wiley
Date: 12-01-2022
Abstract: Polypeptide coatings are a cornerstone in the field of surface modification due to their widespread biological potential. As their properties are dictated by their structural features, subsequent control thereof using unique fabrication strategies is important. Herein, we report a facile method of precisely creating densely crosslinked polypeptide films with unusually high random coil content through continuous assembly polymerization via reversible addition-fragmentation chain transfer (CAP-RAFT). CAP-RAFT was fundamentally investigated using methacrylated poly-l-lysine (PLLMA) and methacrylated poly-l-glutamic acid (PLGMA). Careful technique refinement resulted in films up to 36.1±1.1 nm thick which could be increased to 94.9±8.2 nm after using this strategy multiple times. PLLMA and PLGMA films were found to have 30-50 % random coil conformations. Degradation by enzymes present during wound healing reveals potential for applications in drug delivery and tissue engineering.
A unique 19F MRI agent for the tracking of non phagocytic cells in vivo
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8NR00703A
Abstract: We describe the synthesis and characterization of a novel PFPE-based partially fluorinated copolymer for in vivo tracking of MSCs.
High‐performance thin film composite membranes with well‐defined poly(dimethylsiloxane)‐b‐poly(ethylene glycol) copolymer additives for CO2 separation
Publisher: Wiley
Date: 03-04-2015
DOI: 10.1002/POLA.27628
Cyclodextrin-based supramolecular polymeric nanoparticles for next generation gas separation membranes
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5TA03281D
Abstract: Cyclodextrin-based supramolecular polyrotaxanes are for the first time used as soft nanoparticle additives for the selective layer of composite membranes. They exhibit outstanding gas transport characteristics at low additive percentages, due to the dynamic nature of the PDMS side chains.
Influence of Polymer Elasticity on the Formation of Non‐Cracking Honeycomb Films
Publisher: Wiley
Date: 22-06-2012
Abstract: Non-planar non-cracking honeycomb (HC) structures are prepared from star polymers with high glass transition temperatures (T(g) ) and relatively low Young's moduli (E). This study demonstrates that the Young's modulus of a polymer is a more important factor than the glass transition temperature for determining the occurrence of cracking during HC film formation on non-planar surfaces.
Insights into the mechanochromism of spiropyran elastomers
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9PY00017H
Abstract: Colourless polymeric s les comprising mechanochromic spiropyrans (SPs) rapidly appear coloured under external pressure, due to their transition from ring closed SP to ring-opened merocyanine (MC).
MOF-Mediated Destruction of Cancer Using the Cell’s Own Hydrogen Peroxide
Publisher: American Chemical Society (ACS)
Date: 20-09-2017
Abstract: A novel reduced iron metal-organic framework nanoparticle with cytotoxicity specific to cancer cells is presented. This nanoparticle was prepared via a hydrothermal method, reduced using hydroquinone, and finally conjugated with folic acid (namely, rMOF-FA). The synthesized nanoparticle shows the controlled release of iron in an acidic ex-vivo environment. Iron present on the rMOF-FA and released into solution can react with high levels of hydrogen peroxide found specifically in cancer cells to increase the hydroxyl radical concentration. The hydroxyl radicals oxidize proteins, lipids, and/or DNA within the biological system to decrease cell viability. In vitro experiments demonstrate that this novel nanoparticle is cytotoxic to cancer cells (HeLa) through generation of OH
Blends of Fluorinated Additives with Highly Selective Thin-Film Composite Membranes to Increase CO2 Permeability for CO2/N2 Gas Separation Applications
Publisher: American Chemical Society (ACS)
Date: 22-07-2201
Polyimide polydimethylsiloxane triblock copolymers for thin film composite gas separation membranes
Publisher: Wiley
Date: 10-2014
DOI: 10.1002/POLA.27401
Ultrathin membrane with robust and superior CO2 permeance by precision control of multilayer structures
Publisher: Elsevier BV
Date: 04-2023
Related Organisations
No related organisations have been discovered for Paul Gurr.
Related Funding Activities
Linkage Projects - Grant ID: LP120200010
Start Date: 03-2013
End Date: 12-2015
Amount: $304,000.00
Funder: Australian Research Council
View Funded ActivityLinkage Infrastructure, Equipment And Facilities - Grant ID: LE120100094
Start Date: 06-2012
End Date: 12-2013
Amount: $220,000.00
Funder: Australian Research Council
View Funded Activity