ORCID Profile
0000-0002-9972-6383
Current Organisations
Rutherford Appleton Laboratory
,
University of Bristol
,
University of Sao Paulo
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Publisher: American Physical Society (APS)
Date: 16-06-2021
Publisher: American Physical Society (APS)
Date: 16-06-2020
Publisher: American Physical Society (APS)
Date: 21-06-2021
Publisher: American Association for Cancer Research (AACR)
Date: 12-2018
DOI: 10.1158/1055-9965.EPI-18-0113
Abstract: Circulating insulin-like growth factor binding protein 3 (IGFBP-3) has been associated with prostate cancer. Preclinical studies found that vitamin D regulates IGFBP-3 expression, although evidence from epidemiologic studies is conflicting. Mendelian randomization analyses (MR) were conducted to reassess associations between IGFBP-3 and prostate cancer risk and advanced prostate cancer using summary statistics from the PRACTICAL consortium (44,825 cases 27,904 controls). Observational and MR analyses were conducted to assess the relationship between inactive vitamin D [25(OH)D] and IGFBP-3 using data from the ProtecT study (1,366 cases ,071 controls) and summary statistics from the CHARGE consortium (n = 18,995). The OR for prostate cancer per SD unit increase in circulating IGFBP-3 was 1.14 [95% confidence interval (CI), 1.02–1.28]. The OR for advanced prostate cancer per SD unit increase in IGFBP-3 was 1.22 (95% CI, 1.07–1.40). Observationally, a SD increase in 25(OH)D was associated with a 0.1SD (95% CI, 0.05–0.14) increase in IGFBP-3. MR analyses found little evidence for a causal relationship between circulating 25(OH)D and IGFBP-3 in the circulation. This study provided confirmatory evidence that IGFBP-3 is a risk factor for prostate cancer risk and progression. Observationally, there was evidence that 25(OH)D is associated with IGFBP-3, but MR analyses suggested that these findings were unlikely to be causal. Findings may be limited by the nature of instrumentation of 25(OH)D and IGFBP-3 and the utility of circulating measures. 25(OH)D appears unlikely to be causally related to IGFBP-3 in the circulation, however, our findings do not preclude causal associations at the tissue level. IGFBP-3 is a prostate cancer risk factor but 25(OH)D are unlikely to be causally related to IGFBP-3 in the circulation.
Publisher: Springer Science and Business Media LLC
Date: 10-2020
Abstract: The electron (anti-)neutrino component of the T2K neutrino beam constitutes the largest background in the measurement of electron (anti-)neutrino appearance at the far detector. The electron neutrino scattering is measured directly with the T2K off-axis near detector, ND280. The selection of the electron (anti-)neutrino events in the plastic scintillator target from both neutrino and anti-neutrino mode beams is discussed in this paper. The flux integrated single differential charged-current inclusive electron (anti-)neutrino cross-sections, dσ/dp and dσ/d cos( θ ), and the total cross-sections in a limited phase-space in momentum and scattering angle ( p 300 MeV/c and θ ≤ 45°) are measured using a binned maximum likelihood fit and compared to the neutrino Monte Carlo generator predictions, resulting in good agreement.
Publisher: Springer Science and Business Media LLC
Date: 15-04-2020
Publisher: American Physical Society (APS)
Date: 02-06-2020
Publisher: American Association for Cancer Research (AACR)
Date: 04-2013
DOI: 10.1158/1055-9965.EPI-12-1248
Abstract: Background: Ecological and epidemiological studies have identified an inverse association of intensity and duration of sunlight exposure with prostate cancer, which may be explained by a reduction in vitamin D synthesis. Pigmentation traits influence sun exposure and therefore may affect prostate cancer risk. Because observational studies are vulnerable to confounding and measurement error, we used Mendelian randomization to examine the relationship of sun exposure with both prostate cancer risk and the intermediate phenotype, plasma levels of vitamin D. Methods: We created a tanning, a skin color, and a freckling score as combinations of single nucleotide polymorphisms that have been previously associated with these phenotypes. A higher score indicates propensity to burn, have a lighter skin color and freckles. The scores were tested for association with vitamin D levels (25-hydroxyvitamin-D and 1,25-dihydroxyvitamin-D) and prostate-specific antigen detected prostate cancer in 3,123 White British in iduals enrolled in the Prostate Testing for cancer and Treatment (ProtecT) study. Results: The freckling score was inversely associated with 25(OH)D levels [change in 25(OH)D per score unit −0.27 95% CI, −0.52% to −0.01%], and the tanning score was positively associated with prostate cancer risk (OR = 1.05 95% CI, 1.02–1.09), after adjustment for population stratification and potential confounders. Conclusions: In iduals who tend to burn are more likely to spend less time in the sun and consequently have lower plasma vitamin D levels and higher susceptibility to prostate cancer. Impact: The use of pigmentation-related genetic scores is valuable for the assessment of the potential benefits of sun exposure with respect to prostate cancer risk. Cancer Epidemiol Biomarkers Prev 22(4) 597–606. ©2013 AACR.
Publisher: Public Library of Science (PLoS)
Date: 05-12-2012
Publisher: Elsevier BV
Date: 2001
DOI: 10.1086/316935
Publisher: Oxford University Press (OUP)
Date: 23-08-2016
DOI: 10.1093/HMG/DDW264
Publisher: Springer Science and Business Media LLC
Date: 04-04-2016
Publisher: Springer Science and Business Media LLC
Date: 10-10-2018
Publisher: American Physical Society (APS)
Date: 26-01-2021
Publisher: Wiley
Date: 23-06-2016
DOI: 10.1002/IJC.30206
Publisher: Oxford University Press (OUP)
Date: 10-2016
DOI: 10.5665/SLEEP.6170
Publisher: American Physical Society (APS)
Date: 21-07-2020
Publisher: Hindawi Limited
Date: 20-11-2019
DOI: 10.1155/2019/2680972
Abstract: Complex networks in reality may suffer from target attacks which can trigger the breakdown of the entire network. It is therefore pivotal to evaluate the extent to which a network could withstand perturbations. The research on network robustness has proven as a potent instrument towards that purpose. The last two decades have witnessed the enthusiasm on the studies of network robustness. However, existing studies on network robustness mainly focus on multilayer networks while little attention is paid to multipartite networks which are an indispensable part of complex networks. In this study, we investigate the robustness of multipartite networks under intentional node attacks. We develop two network models based on the largest connected component theory to depict the cascading failures on multipartite networks under target attacks. We then investigate the robustness of computer-generated multipartite networks with respect to eight node centrality metrics. We discover that the robustness of multipartite networks could display either discontinuous or continuous phase transitions. Interestingly, we discover that larger number of partite sets of a multipartite network could increase its robustness which is opposite to the phenomenon observed on multilayer networks. Our findings shed new lights on the robust structure design of complex systems. We finally present useful discussions on the applications of existing percolation theories that are well studied for network robustness analysis to multipartite networks. We show that existing percolation theories are not amenable to multipartite networks. Percolation on multipartite networks still deserves in-depth efforts.
Publisher: Wiley
Date: 10-12-2020
DOI: 10.1111/PCMR.12948
Abstract: Pigmentation characteristics are well‐known risk factors for skin cancer. Polymorphisms in pigmentation genes have been associated with these traits and with the risk of malignancy. However, the functional relationship between genetic variation and disease is still unclear. This study aims to assess whether pigmentation SNPs are associated with pigmentary traits and skin cancer via DNA methylation (DNAm). Using a meta‐GWAS of whole‐blood DNAm from 36 European cohorts ( N = 27,750 the Genetics of DNA Methylation Consortium, GoDMC), we found that 19 out of 27 SNPs in 10 pigmentation genes were associated with 391 DNAm sites across 30 genomic regions. We examined the effect of 25 selected DNAm sites on pigmentation traits, sun exposure phenotypes and skin cancer and on gene expression in whole blood. We uncovered an association of DNAm site cg07402062 with red hair in the Avon Longitudinal Study of Parents and Children (ALSPAC). We also found that the expression of ASIP and CDK10 was associated with hair colour, melanoma and basal cell carcinoma. Our results indicate that DNAm and expression of pigmentation genes may play a role as potential mediators of the relationship between genetic variants, pigmentation phenotypes and skin cancer and thus deserve further scrutiny.
Publisher: Wiley
Date: 19-03-2016
DOI: 10.1002/CAM4.695
Publisher: Cold Spring Harbor Laboratory
Date: 30-04-2020
DOI: 10.1101/2020.04.29.060566
Abstract: Incidence rates for melanoma and non-melanoma skin cancer (NMSC), which includes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), have been steadily increasing in all populations. Populations of European ancestry exhibit the highest rates and therefore, have been widely studied. Pigmentation characteristics are well-known risk factors for skin cancer, particularly fair skin, red hair, blue eyes and the inability to tan. Polymorphisms in established pigmentation-related genes have been associated with these traits and with an increased risk of malignancy. However, the functional relationship between genetic variation and disease is still unclear, with the exception of red hair colour variants in the melanocortin 1 receptor ( MC1R ) gene. The aim of this study was to explore the possibility that non-coding pigmentation SNPs are associated with pigmentary traits and skin cancer via DNA methylation (DNAm). Using a meta-GWAS of whole blood DNAm from 36 European cohorts (N=27,750 the Genetics of DNA Methylation Consortium, GoDMC), we found that 19 out of 27 pigmentation-associated SNPs distributed within 10 genes ( ASIP, BNC2, IRF4, HERC2, MC1R, OCA2, SLC24A4, SLC24A5, SLC45A2, TYR ) were associated with 391 DNAm sites across 30 genomic regions. We selected 25 DNAm sites for further analysis. We examined the effect of the chosen DNAm sites on pigmentation traits, sun exposure phenotypes, and skin cancer, and on gene expression in whole blood. We found an association of decreased DNAm at cg07402062 with red hair in the Avon Longitudinal Study of Parents and Children (ALSPAC), and a strong positive association of DNAm at this and correlated sites with higher expression of SPIRE2 . Additionally, we investigated the association of gene expression in skin with pigmentation traits and skin cancer. The expression of ASIP , FAM83C , NCOA6 , CDK10 , and EXOC2 was associated with hair colour, whilst that of ASIP and CDK10 also had an effect on melanoma and BCC. Our results indicate that DNAm and expression of genes in the 16q24.3 and 20q11.22 regions, deserve to be further investigated as potential mediators of the relationship between genetic variants, pigmentation/sun exposure phenotypes, and some types of skin cancer.
Publisher: Springer Science and Business Media LLC
Date: 09-12-2014
DOI: 10.1007/S10552-014-0500-5
Abstract: Vitamin D pathway single nucleotide polymorphisms (SNPs) are potentially useful proxies for investigating whether circulating vitamin D metabolites [total 25-hydroxyvitamin-D, 25(OH)D 1,25-dihydroxyvitamin, 1,25(OH)2D] are causally related to prostate cancer. We investigated associations of sixteen SNPs across seven genes with prostate-specific antigen-detected prostate cancer. In a nested case-control study (within the ProtecT trial), we estimated odds ratios and 95 % confidence intervals (CIs) quantifying associations between SNPs and prostate cancer. Subgroup analyses investigated whether associations were stronger in men who had high/low sun exposure [a proxy for 25(OH)D]. We quantified associations of SNPs with stage (T1-T2/T3-T4) and grade (<7/≥7). Multiple variant scores included SNPs encoding proteins involved in 25(OH)D synthesis and metabolism. We included 1,275 prostate cancer cases (141 locally advanced, 385 high grades) and 2,062 healthy controls. Vitamin D-binding protein SNPs were associated with prostate cancer (rs4588-A: OR 1.20, CI 1.01, 1.41, p = 0.04 rs7041-T: OR 1.19, CI 1.02, 1.38, p = 0.03). Low 25(OH)D metabolism score was associated with high (vs low) grade (OR 0.76, CI 0.63, 0.93, p = 0.01) there was a similar association of its component variants: rs6013897-A in CYP24A1 (OR 0.78, CI 0.60, 1.01, p = 0.06) and rs10877012-T in CYP27B1 (OR 0.80, CI 0.63, 1.02, p = 0.07). There was no evidence that associations differed by level of sun exposure. We found some evidence that vitamin D pathway SNPs were associated with prostate cancer risk and grade, but not stage. There was no evidence of an association in men with deficient vitamin D (measured by having low sun exposure).
Publisher: Oxford University Press (OUP)
Date: 17-05-2018
DOI: 10.1093/JNCI/DJY081
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Carolina Bonilla.