ORCID Profile
0000-0002-7516-315X
Current Organisations
University Medical Center Groningen
,
James Cook University
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Interdisciplinary Engineering | Turbulent Flows | Fluidization And Fluid Mechanics | Turbulent Flows | Computational Fluid Dynamics | Fluidisation and Fluid Mechanics | Water And Sanitary Engineering | Computational Heat Transfer | Heat And Mass Transfer Operations |
Physical sciences | Industry | Industrial Energy Conservation and Efficiency | Water Allocation and Quantification | Residential Energy Conservation and Efficiency | Atmospheric Processes and Dynamics | Land and water management | Commercial Energy Conservation and Efficiency | Expanding Knowledge in the Earth Sciences | Forest and Woodlands Water Management | Coastal and Estuarine Water Management | Farmland, Arable Cropland and Permanent Cropland Water Management
Publisher: Cambridge University Press (CUP)
Date: 11-07-2008
DOI: 10.1017/S0022112008002310
Abstract: Experimental evidence for previously unreported fountain behaviour is presented. It has been found that the first unstable mode of a three-dimensional round fountain is a laminar flapping motion that can grow to a circling or multimodal flapping motion. With increasing Froude and Reynolds numbers, fountain behaviour becomes more disorderly, exhibiting a laminar bobbing motion. The transition between steady behaviour, the initial flapping modes and the laminar bobbing flow can be approximately described by a function FrRe 2/3 = C . The transition to turbulence occurs at Re 120, independent of Froude number, and the flow appears to be fully turbulent at Re ≈2000. For Fr 10 and Re ≲120, sinuous shear-driven instabilities have been observed in the rising fluid column. For Re ≳120 these instabilities cause the fountain to intermittently breakdown into turbulent jet-like flow. For Fr ≲10 buoyancy forces begin to dominate the flow and pulsing behaviour is observed. A regime map of the fountain behaviour for 0.7≲ Fr ≲100 and 15≲ Re ≲1900 is presented and the underlying mechanisms for the observed behaviour are proposed. Movies are available with the online version of the paper.
Publisher: Elsevier BV
Date: 09-2008
Publisher: Elsevier BV
Date: 12-2016
Publisher: Springer Science and Business Media LLC
Date: 04-05-2016
DOI: 10.1038/EJHG.2016.31
Publisher: Elsevier BV
Date: 04-2020
Publisher: Cambridge University Press (CUP)
Date: 11-05-2010
DOI: 10.1017/S002211201000087X
Abstract: Numerical simulations of fully turbulent weak fountain flow are used to provide direct evidence for the scaling behaviour of fountain flow over the Froude number range Fr = 0.1–2.1 and Reynolds number range Re = 20–3494. For very weak flow at Fr 0.4, the flow mean penetration height, Z m , scales with Z m / R 0 = A 1 Fr 2/3 + A 2 Fr 2/3 where R 0 is the source radius. A 1 and A 2 are constants which quantify the separate effects of the radial acceleration of fountain fluid from the source ( A 1 ) and the backpressure from the surrounding intrusion, if present, on the upflow ( A 2 ). The evidence presented in this work suggests that the mechanisms for the two parts in the scaling of Z m scale with Fr 2/3 . The intrusion behaviour varies with the Reynolds number ( Re ) but there is no Re affect on the fountain penetration height. For Re 250 the radial intrusion flow is subcritical and has different behaviour. For Fr between 0.4 and 2.1 the effect of source momentum flux increases and the flow structure changes to one where there is a coherent upflow and a cap region where the flow stagnates and then reverses. The two regions have separate scaling behaviour such that the overall height, through this transition range of Froude numbers, can be described by Z m / R = C 1 Fr 2/3 + C 2 Fr 2 , where C 1 and C 2 are constants. Over this transition range the effect of source velocity profile is more significant than the Reynolds number effects and the effect of inlet turbulence is minor.
Publisher: American Physical Society (APS)
Date: 24-06-2009
Publisher: Informa UK Limited
Date: 31-07-2007
Publisher: Wiley
Date: 07-09-2023
DOI: 10.1002/HTJ.22691
Abstract: A “fountain filling box” flow produced by discharging a weak laminar plane fountain in a confined open channel is studied numerically. Two‐dimensional direct numerical simulations were performed for weak plane fountains. The development of the fountain flow experiences five stages the initial upflow and the subsequent downflow after the fountain penetrates to the maximum height, followed by the outward movement of the intrusion of the fallen fountain fluid on the channel bottom, and then the wall fountain formed by the impingement of the intrusion on the vertical sidewall, which results in the reversed flow, and finally the gradual stratification of the fluid. The behavior of the intrusion can be approximately described with the plane gravity current theory. The period for the intrusion to reach the bounded side wall increases with increasing Re or decreasing Fr . Three regimes are found for the wall fountain behavior “no‐falling,” “slumping down,” and “rolling down” behavior. Convection, mixing, conduction, and filling all contribute to the formation and development of stratification, but their effects vary at different stages. For the initial stages, convection and mixing play a key role, resulting in an increasing bulk entrainment rate, while conduction and filling are dominant after quasi‐steady stratification is created, presenting a decreasing bulk entrainment rate.
Publisher: Elsevier BV
Date: 08-1995
Publisher: Elsevier BV
Date: 2017
Publisher: Elsevier BV
Date: 03-1989
Publisher: Springer Science and Business Media LLC
Date: 14-04-2015
DOI: 10.1038/MP.2015.37
Publisher: Elsevier BV
Date: 12-1989
Publisher: Elsevier BV
Date: 2002
Publisher: AIP Publishing
Date: 11-2022
DOI: 10.1063/5.0123044
Abstract: A linear temporal stability analysis is conducted for inviscid sheared convective boundary layer flow, in which the sheared instability with stable stratification coexists with and caps over the thermal instability with unstable stratification. The classic Taylor–Goldstein equation is applied with different stratification factors Js and Jb in the Brunt–Väisälä frequency, respectively. Two shear-thermal hybrid instabilities, the hybrid shear stratified (HSS) and hybrid Rayleigh–Bénard (HRB) modes, are obtained by solving the eigenvalue problems. It is found that the temporal growth rates of the HSS and HRB modes vary differently with increased Jb in two distinct wavenumber (α̃) regions defined by the intersection point between the stability boundaries of the HSS and HRB modes. Based on Jb,cr where the temporal growth rate of the HSS and HRB are equal, a map of the unique critical boundary, which separates the effective regions of the HSS and HRB modes, is constructed and found to be dependent on Js, Jb, and α̃. The examinations of the subordinate eigenfunctions indicate that the shear instability is well developed in the HSS mode, in which the large vortex structures may prevail and suppress the formation of convective rolls the shear instability in the HRB mode is either “partly developed” when Jb& Jb,cr or “undeveloped” when Jb& Jb,cr, thus only plays a secondary role to modify the dominant convective rolls, and as Jb increases, the eigenfunctions of the HSS mode exhibit different transitional behaviors in the two regions, signifying the “shear enhancement” and “shear sheltering” of the entrainment of buoyancy flux.
Publisher: Elsevier BV
Date: 12-1990
Publisher: AIP Publishing
Date: 03-2022
DOI: 10.1063/5.0083687
Abstract: The stability features of the inviscid, homogenous, and free cross sheared flow, with base flow velocities U=tanh(z) in the primary direction, which is unstable, and V=ξz3 in the orthogonal direction, which is stable, are thoroughly examined with linear temporal stability analysis, where z is the transverse coordinate perpendicular to the flow and ξ is the cross shear ratio which is the ratio of the characteristic magnitudes of V to U. The map of the unstable regions directly related to χ=ξ(β/α) is obtained, where (β/α) is the ratio between the orthogonal and primary wavenumbers. Further examination of the eigenfunctions shows that the eigenfunction structures ide into the orthogonal wavenumber (OW) mode where (β/α) dominates and the cross shear (CS) mode where ξ dominates. The cross shear is found necessary for stabilization in spite of different fashions for the OW and CS modes. The transition from the OW mode to the CS mode shows that the developments of the two modes inherently compete with each other, so that when ψ=(β/α)/ξ decreases the enhanced cross shear needs to deteriorate the OW mode before it helps the growth of the CS mode. Based on the magnitudes of the associated eigenfunctions in the enstrophy budget, the map of the OW, CS, and hybrid modes, which includes the mixed features of both the OW and CS modes, is produced and discussed.
Publisher: Wiley
Date: 24-03-2023
DOI: 10.1002/HTJ.22852
Abstract: Origami has become an increasingly popular geometry in thermal engineering, namely, heat regulatory applications such as heat sinks and radiators. In this study, the radiative heating and radiative and natural convective cooling of three origami geometries (W‐fold, Miura Ori (1), and Miura Ori (2)) made of heavy‐duty aluminum foil under a radiative heater with different powers (800, 1600, and 2400 W) and different compression lengths (0.15, 0.25, 0.35, and 0.45 m) were investigated. It was found that the Miura Ori (1) and Miura Ori (2) geometries have three to four times high‐temperature differences (the maximum temperature at the end of the heating process minus the initial temperature) than the W‐fold geometry. The Miura Ori (2) and Miura Ori (1) geometries produced high heat capacity enhancements of 1.2–3.2 times at high compression lengths that showed great potential for applications such as solar steam generators. The overall heat transfer coefficient for cooling can be controlled by changing the compression length of the origami geometry, allowing for dynamic surface temperature controls. This parameter decreases by up to 25.3%, 22.6%, and 45.9% for W‐fold, Miura Ori (1), and Miura Ori (2), respectively, in comparison to their flat states.
Publisher: AIP Publishing
Date: 09-2022
DOI: 10.1063/5.0106526
Abstract: Thermal stratification can lead to the d ing of turbulence, which reduces the mixing of solutes in a fluid body. A series of direct numerical simulation (DNS) solutions sweeping through a range of four different meandering channel curvatures, from a sharp to mild curvature range, are obtained to investigate the effect of curvature on stratification in meandering thermally stratified turbulent open channel flow with an internal heat source that models radiative heating from above. Based on the DNS results, the present paper addresses two issues. First, the influence of changing curvature on the complex bi-cellular pattern of the secondary flow is investigated, including the distribution of the temperature field. Second, the effects of changing curvature on the degree of stratification are analyzed. Stratification can be characterized by the friction Richardson number Riτ and the bulk Richardson number Rib. Stratification can also be viewed in terms of the transfer of energy from mean flow kinetic energy to potential energy via buoyancy fluxes. We study the effect of curvature on stratification by investigating its effect on the friction and bulk Richardson numbers. We also study the transfers between the global potential and kinetic energy reservoirs, including the global available Ea, background Eb, and total potential energy Ep, and the domain-averaged mean kinetic and turbulent kinetic energy. It is found that, in meandering channels, with the increase in curvature, Ep increases and Riτ and Rib decrease, indicating that increasing curvature leads to a decrease in the level of stratification. On the other hand, we also find that a low curvature meandering channel has a higher level of stratification than a straight channel.
Publisher: Elsevier BV
Date: 12-1995
Publisher: Elsevier BV
Date: 07-2006
Publisher: American Physical Society (APS)
Date: 21-12-2005
Publisher: Elsevier BV
Date: 09-2000
Publisher: Elsevier BV
Date: 05-1996
Publisher: Begell House
Date: 2015
Publisher: Springer Science and Business Media LLC
Date: 07-2003
Publisher: Elsevier BV
Date: 04-2007
Publisher: AIP Publishing
Date: 03-2022
DOI: 10.1063/5.0083230
Abstract: Direct numerical simulation (DNS) results for turbulent open-channel flow through an idealized sine-generated meander with and without an internal heat source that models radiative heating from above are used to analyze the effect of a very sharp meander configuration and thermal stratification on the turbulence structure in the channel with friction Reynolds number Reτ=200. Spatial distributions of temperature, mean velocities, vorticity, mean-flow kinetic energy, and turbulent kinetic energy (TKE) are presented. In both cases, the cross-sectional motion is characterized by three circulation cells: a center-region cell and two weaker outer bank and inner bank cells. However, there is also a small cell observed near the corner of the channel bed inner bank at the channel outlet and the channel bed outer bank at the channel inlet. The tri-cellular cross-stream motions control the distributions of temperature and kinetic energy. In the stratified case, two separated shear layers (SSLs) are found: the first one is formed before the bend apex, and the second one is observed in the wake after the bend apex. In the neutral case, only the first SSL is observed. Turbulent lification can be seen in both cases however, in the stratified case, the second SSL stretches out to the channel outlet and is introduced back to the channel inlet by an anti-symmetric periodic boundary condition and then follows the outer bank line. The two SSLs converge in the region before the bend apex and lify the turbulence more strongly there than in the neutral case. The turbulence kinetic energy budget terms for the stratified case are analyzed to determine the characteristics of production, dissipation and transport of TKE in thermally stratified meandering flow.
Publisher: Wiley
Date: 15-10-2021
Publisher: American Physical Society (APS)
Date: 26-12-2002
Publisher: Elsevier BV
Date: 2019
Publisher: Elsevier BV
Date: 07-2015
Publisher: Trans Tech Publications, Ltd.
Date: 05-2014
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMM.553.150
Abstract: Fountains are common both in nature and in industrial and environmental settings. These are jet flows with a negative buoyancy force acting in the direction opposite to the jet direction. The onset of asymmetry and unsteadiness, which occurs in transitional fountains with intermediate Reynolds ( Re ) and Froude ( Fr ) numbers, is the key to shed light on the turbulence generation mechanism in fountains. In this study, a series of three-dimensional direct numerical simulations are carried out for transitional round fountains with Re and Fr in the ranges of 1 ≤ Fr ≤ 8, 50 ≤ Re ≤ 500 to reveal their unsteady flow dynamics, in particular the onset of asymmetry, three-dimensionality, and unsteadiness. The numerical results show that the onset of asymmetry and unsteadiness can be detected and quantified by the tangent velocity on the interfacial surface between the fountain fluid and the ambient fluid. The results also demonstrate that a critical Re is at about 165 for Fr =2 fountains and is reduced to about 65 for Fr =3 fountains. Similarly, a critical Fr exists between 2 and 3 for the Re = 100 fountains, whereas for Re = 200 fountains it reduces to be between 1.8 and 2.
Publisher: Elsevier BV
Date: 07-2015
Publisher: Elsevier BV
Date: 03-2000
Publisher: IEEE
Date: 2009
Publisher: Elsevier BV
Date: 2000
Publisher: Informa UK Limited
Date: 06-04-2023
Publisher: Informa UK Limited
Date: 03-07-2013
Publisher: Cambridge University Press (CUP)
Date: 08-02-2011
DOI: 10.1017/S0022112010005872
Abstract: Numerical simulations of turbulent fountain flow are used to investigate the important energy and mass transfer mechanisms present in the forced fountain flow regime, which has been reported to exist at Froude numbers ( Fr ) greater than 3. The flow is equivalent to a negatively buoyant jet with three flow streams, the inner upflow (IF), the outer downflow (OF) and the surrounding ambient fluid (AF). Simulation results are presented for Fr = 4 and 7 at Reynolds number Re = 3350. The mean fountain penetration height scales with the previously reported relation Z m / R 0 = 2.46 Fr , where R 0 is the source radius, but the assumptions behind analytical derivations of the relation are not supported by the present results. The results suggest that the OF may be relatively well described by the dynamics of a pure line plume surrounding the IF but with higher entrainment owing to the unsteady pulsing behaviour of the flow entering the OF from the IF. The length scale for a pure plume appears to apply at Fr = 7 in the OF and a degree of self-similarity exists. Comparisons with previous results suggest the IF is not fully developed at Fr = 7 and entrainment into the IF from the OF may not occur until Fr 15.
Publisher: World Scientific Pub Co Pte Ltd
Date: 04-2022
DOI: 10.1142/S175882512250020X
Abstract: Thermal entrainment is an integral feature of free-shear flows involving temperature changes, including fountains (negatively buoyant jets). The understanding of thermal entrainment is essential for applications involving thermal stratification such as that in a solar water storage tank. In this study, thermal entrainment in the core regions of transitional plane fountains in linearly-stratified ambient fluids is studied numerically over a range of the Froude number, Reynolds number, and dimensionless thermal stratification parameter. The results show that thermal entrainment has a negligible effect on the inner core region, but is significant in the outer core region, particularly at the interfaces among the upflow, downflow, and ambient fluid, and the thermal entrainment parameter, which quantifies the extent of thermal entrainment, decreases with height or in a stronger stratification, but increases with increasing Froude number or Reynolds number. Several numerical relations are obtained with the numerical results for the thermal entrainment parameter.
Publisher: Wiley
Date: 21-12-2022
DOI: 10.1002/HTJ.22431
Abstract: The understanding of the transient behavior of the natural convection boundary layer on a heated vertical solid surface is crucial for numerous applications. In this study, scaling analysis is performed to derive the scaling laws for the major parameters that characterize the transient behavior of natural convection boundary layer of a Prandtl number larger than 1 fluid on a vertical solid surface subject to a sinusoidal heating flux in a linearly stratified ambient. It is found that the developed scaling laws are in good agreement with the direct numerical simulation results over wide ranges of Prandtl number, stratification parameter, and frequency of the sinusoidal heat flux.
Publisher: Elsevier BV
Date: 09-1998
Publisher: American Association for the Advancement of Science (AAAS)
Date: 21-06-2013
Abstract: Many genomic elements in humans are associated with behavior, including educational attainment. In a genome-wide association study including more than 100,000 s les, Rietveld et al. (p. 1467 , published online 30 May see the Perspective by Flint and Munafò ) looked for genes related to educational attainment in Caucasians. Small genetic effects at three loci appeared to impact educational attainment.
Publisher: Cambridge University Press (CUP)
Date: 15-02-2007
DOI: 10.1017/S0022112006003703
Abstract: The flow behaviour associated with the cooling of an initially quiescent isothermal Newtonian fluid with Prandtl number Pr less than unity in a rectangular container by unsteady natural convection with an imposed lower temperature on vertical sidewalls is investigated by scaling analysis and direct numerical simulation. The flow is dominated by two distinct stages of development. i.e the boundary-layer development stage adjacent to the sidewall and the subsequent cooling-down stage. The first stage can be further ided into a start-up stage, transitional stage, and steady-state stage. The parameters characterizing the flow behaviour are the boundary-layer thickness, the maximum vertical velocity within the boundary layer, the time for the boundary layer to reach the steady state, the Nusselt number across the sidewall at the boundary-layer development stage, the time for the fluid in the container to be fully cooled down, and the average fluid temperature over the whole volume of the container.
Publisher: MDPI AG
Date: 18-04-2023
DOI: 10.3390/EN16083505
Abstract: Telecommunication systems have become a critical part of society which enables connectivity to many essential and trivial services. Consequently, telecommunication equipment is housed in cabinets to protect the electronics from a variety of hazards one of which is temperature-related failure. Current practices use a notable amount of power for the thermal management of telecommunication cabinets which can be reduced by considering alternative methods of cooling. In this paper, experiments were carried out to investigate the effectiveness of different internal mounting configurations of electronic components on the thermal performance of a telecommunication cabinet. The investigation tested inclinations (0–90°), different staggered offsets (0–50 mm), changing stream-wise spacing (29–108 mm), and fan speed (with a Reynolds number in the range of 1604 to 5539). The experimental study revealed that heat transfer was enhanced by 9.99% by altering component inclination to 90°, 25.90% by increasing stream-wise spacing from 29 mm to 108 mm, and 36.02% by increasing the Reynolds number from 1604 to 5539. However, the staggered arrangement of internal components decreased Nu by 3.26% for the natural convection condition but increased by 5.69% for the forced convection condition over the tested range and increasing the centre offset of the staggered components with respect to the cabinet did not influence Nu in any significant manner. Natural convection and forced convection also had notable influence on the heat transfer rate. Hence it was seen that alternative internal configurations positively influence heat transfer in telecommunication cabinets for the cases studied.
Publisher: Elsevier BV
Date: 12-2009
Publisher: Elsevier BV
Date: 05-1996
Publisher: Springer Science and Business Media LLC
Date: 11-02-2015
DOI: 10.1038/NATURE14177
Publisher: Proceedings of the National Academy of Sciences
Date: 08-09-2014
Abstract: We identify several common genetic variants associated with cognitive performance using a two-stage approach: we conduct a genome-wide association study of educational attainment to generate a set of candidates, and then we estimate the association of these variants with cognitive performance. In older Americans, we find that these variants are jointly associated with cognitive health. Bioinformatics analyses implicate a set of genes that is associated with a particular neurotransmitter pathway involved in synaptic plasticity, the main cellular mechanism for learning and memory. In addition to the substantive contribution, this work also serves to show a proxy-phenotype approach to discovering common genetic variants that is likely to be useful for many phenotypes of interest to social scientists (such as personality traits).
Publisher: Elsevier BV
Date: 1991
Publisher: MDPI AG
Date: 15-07-2023
DOI: 10.3390/EN16145394
Abstract: Hydropower is one of the most sustainable and desirable renewable energy sources. Gravitational water vortex hydro turbine (GWVHT) systems are one of the most suitable and sustainable renewable power generation devices for remote and rural areas, particularly in developing countries, owing to their small scales and low costs. There are various GWVHT systems with different configurations and various operating conditions. The main components of a GWVHT system include the inlet and outlet channels, a basin, and a turbine on which there are a number of blades attached. This paper presents a comprehensive review regarding the progress and development of various GWVHT systems, covering broad aspects of GWVHT systems, particularly various types of basins, inlet and outlet channels, turbines with blades which have different shapes, orientations, sizes, numbers, etc. The nature of the previous studies is summarised. The fundamentals of the vortex dynamics involved and the quantitative analysis of the performance of GWVHT systems are also described. The turbulence models and multiphase models used in some leading numerical simulation studies have been reviewed. As a case study, the implementation of a GWVHT system in PNG is presented. Based on the review of previous studies regarding GWVHT systems, the major issues and challenges are summarised, and some key topics are recommended for future research work on the performance of GWVHT systems.
Publisher: Elsevier BV
Date: 10-2016
Publisher: Elsevier BV
Date: 06-2010
Publisher: Springer Science and Business Media LLC
Date: 05-10-2014
DOI: 10.1038/NG.3097
Publisher: Springer Science and Business Media LLC
Date: 14-04-2005
Publisher: Elsevier BV
Date: 11-2015
Publisher: Elsevier BV
Date: 2000
Publisher: American Society of Civil Engineers (ASCE)
Date: 09-2023
Publisher: Elsevier BV
Date: 2011
Publisher: Elsevier BV
Date: 05-2009
Publisher: Elsevier BV
Date: 02-2001
Publisher: Shanghai Institute of Optics and Fine Mechanics
Date: 2009
Publisher: Informa UK Limited
Date: 10-02-2014
Publisher: American Physical Society (APS)
Date: 18-12-2013
Publisher: Informa UK Limited
Date: 19-07-2019
Publisher: AIP Publishing
Date: 12-2021
DOI: 10.1063/5.0070695
Abstract: A linear temporal stability analysis is carried out on non-parallel free cross sheared flow consisting of the unstable hyperbolic velocity U=tanh(z) in the primary direction and the comparable unstable Bickley jet velocity V=sech2(z) in the orthogonal direction, where z is the coordinate perpendicular to the plane of the primary and orthogonal directions. The cross sheared flow involves the non-parallel effects such as twisted flow and cross flow. The linearized perturbation equations are derived which are subsequently used to examine the stability features. It is found that the instability associated with U=tanh(z) and V=sech2(z) transitions asymptotically to each other as the combined factor χ=ξ(β/α) varies, where ξ=||V||/||U|| is the cross shear ratio and β/α is the ratio between the orthogonal and primary wavenumbers with || || representing the characteristic magnitudes of the velocity components. In addition to the hyperbolic flow (HF) mode and the Bickley jet flow (BJF) mode associated with U=tanh(z) and V=sech2(z), respectively, the orthogonal wavenumber (OW) mode where β/α dominates and the cross shear (CS) mode where ξ dominates are found in the eigenfunction structures. The physical mechanisms of the four eigenfunctions modes are examined with the kinetic energy and enstrophy budgets. The map of the unstable regions influenced and dominated by the OW, CS, HF, and BJF eigenfunction modes is also obtained and discussed.
Publisher: Elsevier BV
Date: 2005
Publisher: Author(s)
Date: 2018
DOI: 10.1063/1.5046230
Publisher: Elsevier BV
Date: 06-2011
Publisher: Elsevier BV
Date: 09-1990
Publisher: Trans Tech Publications, Ltd.
Date: 05-2014
DOI: 10.4028/WWW.SCIENTIFIC.NET/AMM.553.193
Abstract: Modern GPUs (graphical processing units) are a common source of processing power inmany supercomputers. Their performance derives from the highly parallel architecture that is em-ployed and have the benefit of low cost, temperature and power consumption. Two finite differencemodels have been implemented on GPU, a semi-implicit and an explicit algorithm, to numericallymodel a stratified shear layer, that needs fine meshes to be modelled accurately. The GPU modelswere shown to improve performance by factors of around 50x and 20x for the semi-implicit and ex-plicit models respectively.
Publisher: Elsevier BV
Date: 05-2013
Publisher: Elsevier BV
Date: 04-2010
Publisher: American Physical Society (APS)
Date: 18-07-2005
Publisher: Elsevier BV
Date: 07-2017
Publisher: Elsevier BV
Date: 10-2021
Publisher: Elsevier BV
Date: 10-2008
Publisher: American Physical Society (APS)
Date: 14-12-2012
Publisher: Elsevier BV
Date: 2008
Publisher: Elsevier BV
Date: 1988
Publisher: Elsevier BV
Date: 11-1992
Publisher: Elsevier BV
Date: 2000
Publisher: Elsevier BV
Date: 09-2009
Publisher: Elsevier BV
Date: 03-1998
Publisher: Elsevier BV
Date: 02-2017
Publisher: Springer Science and Business Media LLC
Date: 07-04-2022
DOI: 10.1007/S00259-022-05763-3
Abstract: Patients undergoing prophylactic central compartment dissection (PCLND) for papillary thyroid cancer (PTC) are often overtreated. This study aimed to determine if molecular fluorescence-guided imaging (MFGI) and spectroscopy can be useful for detecting PTC nodal metastases (NM) and to identify negative central compartments intraoperatively. We used a data-driven prioritization strategy based on transcriptomic profiles of 97 primary PTCs and 80 normal thyroid tissues (NTT) to identify tumor-specific antigens for a clinically available near-infrared fluorescent tracer. Protein expression of the top prioritized antigen was immunohistochemically validated with a tissue microarray containing primary PTC ( n = 741) and NTT ( n = 108). Staining intensity was correlated with 10-year locoregional recurrence-free survival (LRFS). A phase 1 study (NCT03470259) with EMI-137, targeting MET, was conducted to evaluate safety, optimal dosage for detecting PTC NM with MFGI, feasibility of NM detection with quantitative fiber-optic spectroscopy, and selective binding of EMI-137 for MET. MET was selected as the most promising antigen. A worse LRFS was observed in patients with positive versus negative MET staining (81.9% versus 93.2% p = 0.02). In 19 patients, no adverse events related to EMI-137 occurred. 0.13 mg/kg EMI-137 was selected as optimal dosage for differentiating NM from normal lymph nodes using MFGI ( p 0.0001) and spectroscopy ( p 0.0001). MFGI identified 5/19 levels (26.3%) without NM. EMI-137 binds selectively to MET. MET is overexpressed in PTC and associated with increased locoregional recurrence rates. Perioperative administration of EMI-137 is safe and facilitates NM detection using MFGI and spectroscopy, potentially reducing the number of negative PCLNDs with more than 25%. NCT03470259.
Publisher: Elsevier BV
Date: 02-2017
Publisher: Elsevier BV
Date: 06-2015
Publisher: Elsevier BV
Date: 06-2016
Publisher: Informa UK Limited
Date: 21-01-2020
Publisher: Informa UK Limited
Date: 15-05-2007
Publisher: Elsevier BV
Date: 12-2009
Publisher: Informa UK Limited
Date: 15-11-2007
Publisher: Elsevier BV
Date: 04-2007
Publisher: Elsevier BV
Date: 12-2021
Publisher: Elsevier BV
Date: 10-2009
Publisher: IOP Publishing
Date: 08-2009
Publisher: Elsevier BV
Date: 10-2022
Publisher: Springer Science and Business Media LLC
Date: 11-02-2015
DOI: 10.1038/NATURE14132
Publisher: Elsevier BV
Date: 04-1992
Publisher: Elsevier BV
Date: 11-1989
Start Date: 2016
End Date: 2019
Funder: Australian Research Council
View Funded ActivityStart Date: 06-2013
End Date: 12-2017
Amount: $425,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2004
End Date: 12-2006
Amount: $222,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 06-2016
End Date: 12-2020
Amount: $300,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 04-2015
End Date: 12-2019
Amount: $335,100.00
Funder: Australian Research Council
View Funded ActivityStart Date: 06-2009
End Date: 12-2014
Amount: $300,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 05-2005
End Date: 11-2008
Amount: $375,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 07-2011
End Date: 06-2016
Amount: $350,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 2008
End Date: 12-2010
Amount: $450,000.00
Funder: Australian Research Council
View Funded Activity