ORCID Profile
0000-0003-2673-0485
Current Organisation
University of Toronto
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Publisher: Rockefeller University Press
Date: 03-10-2018
DOI: 10.1084/JEM.20181468
Abstract: Immune protection relies on the capacity of neutrophils to infiltrate challenged tissues. Naive tissues, in contrast, are believed to remain free of these cells and protected from their toxic cargo. Here, we show that neutrophils are endowed with the capacity to infiltrate multiple tissues in the steady-state, a process that follows tissue-specific dynamics. By focusing in two particular tissues, the intestine and the lungs, we find that neutrophils infiltrating the intestine are engulfed by resident macrophages, resulting in repression of Il23 transcription, reduced G-CSF in plasma, and reinforced activity of distant bone marrow niches. In contrast, diurnal accumulation of neutrophils within the pulmonary vasculature influenced circadian transcription in the lungs. Neutrophil-influenced transcripts in this organ were associated with carcinogenesis and migration. Consistently, we found that neutrophils dictated the diurnal patterns of lung invasion by melanoma cells. Homeostatic infiltration of tissues unveils a facet of neutrophil biology that supports organ function, but can also instigate pathological states.
Publisher: Springer Science and Business Media LLC
Date: 23-06-2020
Publisher: Springer Science and Business Media LLC
Date: 11-09-2017
DOI: 10.1038/NG.3947
Publisher: Springer Science and Business Media LLC
Date: 04-07-2014
DOI: 10.1038/NRI3714
Publisher: Wiley
Date: 28-09-2016
Publisher: Elsevier BV
Date: 02-2019
Publisher: Springer Science and Business Media LLC
Date: 07-09-2012
DOI: 10.1038/NRI3300
Abstract: Although the field has a long collaborative tradition, immunology has made less use than genetics of 'consortium biology', wherein groups of investigators together tackle large integrated questions or problems. However, immunology is naturally suited to large-scale integrative and systems-level approaches, owing to the multicellular and adaptive nature of the cells it encompasses. Here, we discuss the value and drawbacks of this organization of research, in the context of the long-running 'big science' debate, and consider the opportunities that may exist for the immunology community. We position this analysis in light of our own experience, both positive and negative, as participants of the Immunological Genome Project.
Start Date: 2002
End Date: 2005
Funder: Canadian Institutes of Health Research
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