ORCID Profile
0000-0002-5162-5188
Current Organisation
University of Zurich
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Publisher: BMJ
Date: 08-2023
DOI: 10.1136/BMJOPEN-2023-074142
Abstract: The implementation of complex interventions is considered challenging, particularly in multi-site clinical trials and dynamic clinical settings. This study protocol is part of the family intensive care units (FICUS) hybrid effectiveness-implementation study. It aims to understand the integration of a multicomponent family support intervention in the real-world context of adult intensive care units (ICUs). Specifically, the study will assess implementation processes and outcomes of the study intervention, including fidelity, and will enable explanation of the clinical effectiveness outcomes of the trial. This mixed-methods multiple case study is guided by two implementation theories, the Normalisation Process Theory and the Consolidated Framework for Implementation Research. Participants are key clinical partners and healthcare professionals of eight ICUs allocated to the intervention group of the FICUS trial in the German-speaking part of Switzerland. Data will be collected at four timepoints over the 18-month active implementation and delivery phase using qualitative (small group interviews, observation, focus group interviews) and quantitative data collection methods (surveys, logs). Descriptive statistics and parametric and non-parametric tests will be used according to data distribution to analyse within and between cluster differences, similarities and factors associated with fidelity and the level of integration over time. Qualitative data will be analysed using a pragmatic rapid analysis approach and content analysis. Ethics approval was obtained from the Cantonal Ethics Committee of Zurich BASEC ID 2021-02300 (8 February 2022). Study findings will provide insights into implementation and its contribution to intervention outcomes, enabling understanding of the usefulness of applied implementation strategies and highlighting main barriers that need to be addressed for scaling the intervention to other healthcare contexts. Findings will be disseminated in peer-reviewed journals and conferences. Open science framework (OSF) osf.io/8t2ud Registered on 21 December 2022.
Publisher: Research Square Platform LLC
Date: 16-11-2022
DOI: 10.21203/RS.3.RS-1645057/V1
Abstract: Background: With a high mortality of 12.6% of all cancer cases, colorectal cancer (CRC) is a substantial burden of disease in Europe. In the past decade, more and more countries have introduced organized colorectal cancer screening programs, making systematic screening available to entire segments of a population, typically based on routine stool tests and/or colonoscopy. While the effectiveness of organized screening in reducing CRC incidence and mortality has been confirmed, studies continuously report persistent program implementation challenges. This systematic review will synthesize the literature on organized colorectal cancer screening programs. Its aim is to understand what is currently known about the barriers and facilitators, that influence the implementation of these programs, and about the implementation strategies used to navigate these determinants. Methods: A systematic review of primary studies of any research design will be conducted. CINAHL, Cochrane, EMBASE, International Clinical Trials Registry Platform, MEDLINE, PsycINFO and Scopus will be searched. Websites of (non-)government health care organizations and websites of organizations affiliated with authors of included studies will be screened for unpublished evaluation reports. Existing organized CRC screening programs will be contacted with a request to share program-specific grey literature. Two researchers will independently screen each publication in two rounds for eligibility. Included studies will focus on adult populations involved in the implementation of organized CRC screening programs and contain information about implementation determinants/ strategies. Publications will be assessed for their risk of bias. Data extraction will include study aim, design, location, setting, s le, methods, and measures program characteristics implementation stage, framework, determinant, strategies, and outcomes and service and other outcome information. Findings will be synthesized narratively using the three stages of thematic synthesis. Discussion: With its sole focus on the implementation of organized CRC screening programs, this review will help to fill a central knowledge gap in the literature on colorectal cancer screening. Its findings can inform the decision making in policy and practice needed to prioritize resources for establishing new and maintaining existing programs in the future. Systematic review registration PROSPERO (CRD42022306580)
Publisher: Springer Science and Business Media LLC
Date: 27-02-2023
DOI: 10.1186/S13643-023-02193-6
Abstract: With a high mortality of 12.6% of all cancer cases, colorectal cancer (CRC) accounts for substantial burden of disease in Europe. In the past decade, more and more countries have introduced organized colorectal cancer screening programs, making systematic screening available to entire segments of a population, typically based on routine stool tests and/or colonoscopy. While the effectiveness of organized screening in reducing CRC incidence and mortality has been confirmed, studies continuously report persistent program implementation challenges. This systematic review will synthesize the literature on organized CRC screening programs. Its aim is to understand what is currently known about the barriers and facilitators that influence the implementation of these programs and about the implementation strategies used to navigate these determinants. A systematic review of primary studies of any research design will be conducted. CENTRAL, CINAHL, EMBASE, International Clinical Trials Registry Platform, MEDLINE, PsycINFO, and Scopus will be searched. Websites of (non-)government health care organizations and websites of organizations affiliated with authors of included studies will be screened for unpublished evaluation reports. Existing organized CRC screening programs will be contacted with a request to share program-specific grey literature. Two researchers will independently screen each publication in two rounds for eligibility. Included studies will focus on adult populations involved in the implementation of organized CRC screening programs and contain information about implementation determinants/ strategies. Publications will be assessed for their risk of bias. Data extraction will include study aim, design, location, setting, s le, methods, and measures program characteristics implementation stage, framework, determinants, strategies, and outcomes and service and other outcome information. Findings will be synthesized narratively using the three stages of thematic synthesis. With its sole focus on the implementation of organized CRC screening programs, this review will help to fill a central knowledge gap in the literature on colorectal cancer screening. Its findings can inform the decision-making in policy and practice needed to prioritize resources for establishing new and maintaining existing programs in the future. PROSPERO (CRD42022306580).
Publisher: F1000 Research Ltd
Date: 20-09-2022
DOI: 10.12688/HRBOPENRES.13507.2
Abstract: Background: Tailoring strategies to target the salient barriers to and enablers of implementation is considered a critical step in supporting successful delivery of evidence based interventions in healthcare. Theory, evidence, and stakeholder engagement are considered key ingredients in the process however, these ingredients can be combined in different ways. There is no consensus on the definition of tailoring or single method for tailoring strategies to optimize impact, ensure transparency, and facilitate replication. Aim: The purpose of this scoping review is to describe how tailoring has been undertaken within healthcare to answer questions about how it has been conceptualised, described, and conducted in practice, and to identify research gaps. Methods: The review will be conducted in accordance with best practice guidelines and the Preferred Reporting Items for Systematic Reviews and Meta-analysis extension for scoping reviews (PRISMA-ScR) will be used to guide the reporting. Searches will be conducted of MEDLINE, Embase, Web of Science, Scopus, from 2005 to present. Reference lists of included articles will be searched. Grey literature will be searched on Google Scholar. Screening and data extraction will be conducted by two or more members of the research team, with any discrepancies resolved by consensus discussion with a third reviewer. Initial analysis will be quantitative involving a descriptive numerical summary of the characteristics of the studies and the tailoring process. Qualitative content analysis aligned to the research questions will also be conducted, and data managed using NVivo where applicable. This scoping review is pre-registered with the Open Science Framework. Conclusions: The findings will serve a resource for implementation researchers and practitioners to guide future research in this field and facilitate systematic, transparent, and replicable development of tailored implementation strategies.
Publisher: SMW Supporting Association
Date: 10-12-2022
Publisher: Frontiers Media SA
Date: 23-03-2022
DOI: 10.3389/FPUBH.2022.836552
Abstract: When empirically supported interventions are implemented in real-world practice settings, the process of how these interventions are implemented is highly relevant for their potential success. Implementation Mapping is a method that provides step-by-step guidance for systematically designing implementation processes that fit the respective intervention and context. It includes needs assessments among relevant stakeholders, the identification of implementation outcomes and determinants, the selection and design of appropriate implementation strategies, the production of implementation protocols and an implementation outcome evaluation. Implementation Mapping is generally conceptualized as a tool to prospectively guide implementation. However, many implementation efforts build on previous or ongoing implementation efforts, i.e., “existing implementation.” Learnings from existing implementation may offer insights critical to the success of further implementation activities. In this article, we present a modified Implementation Mapping methodology to be applied when evaluating existing implementation. We illustrate the methodology using the ex le of evaluating ongoing organized colorectal cancer screening programs in Switzerland. Through this ex le, we describe how we identify relevant stakeholders, implementation determinants and outcomes as well as currently employed implementation strategies. Moreover, we describe how we compare the types of strategies that are part of existing implementation efforts with those that implementation science would suggest as being suited to address identified implementation determinants. The results can be used for assessing the current state of implementation outcomes, refining ongoing implementation strategies, and informing future implementation efforts.
Publisher: Frontiers Media SA
Date: 14-06-2023
Publisher: Elsevier BV
Date: 11-2022
DOI: 10.1016/J.CMI.2022.11.007
Abstract: The most prevalent infections encountered in neonatal care are healthcare-associated infections (HAIs). The majority of HAIs are considered preventable by evidence-based infection prevention and control (IPC) practices, but substantial knowledge gaps exist in IPC implementation in neonatal care. Furthermore, knowledge of factors that facilitate or challenge IPC programme uptake and sustainment in neonatal units is limited. The integration of implementation science approaches within IPC programmes in neonatal care aims to address these problems. The aim of this narrative review was to identify determinants that have been reported to influence the implementation of IPC programmes and best practices in inpatient neonatal care settings. A literature search was conducted in PubMed, MEDLINE and CINAHL in May 2022. Primary study reports published since 2000 in English, French, German, Spanish, Portuguese, Italian, Danish, Swedish, or Norwegian were eligible for inclusion. Included studies focused on IPC practices in inpatient neonatal care settings and reported determinants that influenced implementation processes. The Consolidated Framework for Implementation Research was used to identify and cluster reported determinants to the implementation of IPC practices and programmes in neonatal care. Most studies reported challenges and facilitators at the organisational level as particularly relevant to implementation processes. Commonly reported determinants included staffing levels, work- and caseloads, as well as aspects of organisational culture, such as communication and leadership. The presented knowledge about factors influencing neonatal IPC can support the design, implementation, and evaluation of IPC practices.
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Lauren Clack.