ORCID Profile
0000-0002-4483-5689
Current Organisation
University of Minho Braga - I3Bs - Research Institute for Biomaterials, Biodegradables and Biomimetics
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Publisher: Future Medicine Ltd
Date: 05-2016
Abstract: Aim: To expand our understanding on the effect of magnetically actuated biomaterials in stem cells, inflammation and fibrous tissue growth. Materials & methods: Magnetic biomaterials were obtained by doping iron oxide particles into starch poly-ϵ-caprolactone (SPCL) to create two formulations, magSPCL-1.8 and 3.6. Stem cell behavior was assessed in vitro and the inflammatory response, subcutaneously in Wistar rats. Results: Metabolic activity and proliferation increased significantly overtime in SPCL and magSPCL-1.8. Electromagnetic fields attenuated the presence of mast cells and macrophages in tissues surrounding SPCL and magSPCL-1.8, between weeks 1 and 9. Macrophage reduction was more pronounced for magSPCL-1.8, which could explain why this material prevented growth of fibrous tissue overtime. Conclusion: Magnetically actuated biomaterials have potential to modulate inflammation and the growth of fibrous tissue.
Publisher: Mary Ann Liebert Inc
Date: 05-2008
Publisher: Mary Ann Liebert Inc
Date: 09-2015
Publisher: Springer International Publishing
Date: 2020
Location: Portugal
Location: United States of America
Location: Portugal
Location: Portugal
No related grants have been discovered for Márcia Rodrigues.