ORCID Profile
0000-0002-7238-6235
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Publisher: Institute of Electronics, Information and Communications Engineers (IEICE)
Date: 2011
DOI: 10.1587/ELEX.8.670
Publisher: S. Karger AG
Date: 11-11-2015
DOI: 10.1159/000440642
Abstract: b i Background: /i /b Oxygen saturation (SpO sub /sub ) targeting in the preterm infant may be improved with a better understanding of the SpO sub /sub responses to changes in inspired oxygen (FiO sub /sub ). b i Objective: /i /b We investigated the first-order FiO sub /sub -SpO sub /sub relationship, aiming to quantify the parameters governing that relationship, the influences on these parameters and their variability. b i Methods: /i /b In recordings of FiO sub /sub and SpO sub /sub from preterm infants on continuous positive airway pressure and supplemental oxygen, we identified unique FiO sub /sub adjustments and mapped the subsequent SpO sub /sub responses. For responses identified as first-order, the delay, time constant and gain parameters were determined. Clinical and physiological predictors of these parameters were sought in regression analysis, and intra- and inter-subject variability was evaluated. b i Results: /i /b In 3,788 h of available data from 47 infants at 31 (28-33) post-menstrual weeks [median (interquartile range)], we identified 993 unique FiO sub /sub adjustments followed by a first-order SpO sub /sub response. All response parameters differed between FiO sub /sub increments and decrements, with increments having a shorter delay, longer time constant and higher gain [2.9 (1.7-4.8) vs. 1.3 (0.58-2.6), p 0.05]. Gain was also higher in less mature infants and in the setting of recent SpO sub /sub instability, and was diminished with increasing severity of lung dysfunction. Intra-subject variability in all parameters was prominent. b i Conclusions: /i /b First-order SpO sub /sub responses show variable gain, influenced by the direction of FiO sub /sub adjustment and the severity of lung disease, as well as substantial intra-subject parameter variability. These findings should be taken into account in adjustment of FiO sub /sub for SpO sub /sub targeting in preterm infants.
Publisher: BMJ
Date: 08-06-2015
DOI: 10.1136/ARCHDISCHILD-2014-308108
Abstract: Oxygen saturation (SpO2) signal dropout leaves caregivers without a reliable measure to guide oxygen therapy. We studied SpO2 dropout in preterm infants on continuous positive airway pressure, noting the SpO2 values at signal loss and recovery and thus the resultant change in SpO2, and the factors influencing this parameter. In 32 infants of median gestation 26 weeks, a total of 3932 SpO2 dropout episodes were identified (1.1 episodes/h). In the episodes overall, SpO2 decreased by 1.1%, with the SpO2 change influenced by starting SpO2 (negative correlation), but not dropout duration. For episodes starting in hypoxia (SpO2 <85%), SpO2 recovered at a median of 3.2% higher than at SpO2 dropout, with a downward trajectory in a quarter of cases. We conclude that after signal dropout SpO2 generally recovers in a relative normoxic range. Blind FiO2 adjustments are thus unlikely to be of benefit during most SpO2 dropout episodes.
Publisher: Peertechz Publications Private Limited
Date: 28-12-2022
Abstract: Human populations can be characterized by their corresponding phenotypic profiles which do not necessarily align. These differences are not our points of strength in building harmonious societies and establishing a sustainable world order it is therefore desirable to seek a pathway to resolve them. This article reflects on genetics as the most profound source of our differences and introduces Voluntary Selection as a means of acquiring genetic qualities and resolving the imbalance in their possession by different populations. Voluntary Selection is a healthcare program allowing for voluntarily involving the reproductive cells of another in idual than the parents to conceive a child at the discretion of a parent population. Genetic qualities in this context are desired phenotypes as perceived by each population. The article then presents a computational approach through which thoughtful decisions about the design of a program can be made. These methods are applied to a pedigree data set of adult heights and the results are used to demonstrate the influence of the program design and the significance of its outcomes.
Publisher: IOP Publishing
Date: 29-05-2014
DOI: 10.1088/0967-3334/35/7/1425
Abstract: In this paper an investigation of the gain, delay, and time-constant parameters of the transfer function describing the relation between fraction of inspired oxygen (FiO2) and oxygen saturation in the blood (SpO2) in preterm infants is presented. The parameters were estimated following FiO2 adjustments and goodness of fit was used to assess the validity of the model when using an assumed first-order transfer function. For responses identified to be first-order, the estimated parameters were then clustered to identify areas where they tended to be concentrated. Each group described an operating region of the transfer function thus, predicting the right operating region could potentially assist a range-based robust inspired oxygen controller to provide more optimal control by adapting itself to different clusters. Accordingly, the s les were assigned labels based on their cluster associations and 14 features available at the time of each adjustment were used as inputs to an artificial neural network to classify the clustered s les. The validity study suggested that 37% of the adjustments were followed by first-order responses. Prediction studies on the first-order responses indicated that the clusters could be predicted with an average accuracy of 64% when the parameters were ided into two groups.
Publisher: Elsevier BV
Date: 07-2016
Publisher: Informa UK Limited
Date: 25-11-2015
Publisher: Springer Science and Business Media LLC
Date: 20-02-2016
DOI: 10.1007/S10877-016-9847-3
Abstract: Automated control of inspired oxygen for newborn infants is an emerging technology, currently limited by reliance on a single input signal (oxygen saturation, SpO
Publisher: Peertechz Publications Private Limited
Date: 04-05-2023
DOI: 10.17352/GJE.000079
Abstract: This article is a follow-up on the recent publication introducing the concept of “Voluntary Selection” which allows for engineering the phenotypic profile of a population by adopting the reproductive cells of donors rather than couples themselves. Foreseeing a genetically converging world through Voluntary Selection, and looking from a Middle Eastern and North African perspective, the article focuses on five major themes where improvements are necessary to allow for maintaining stability and achieving a minimum level of living standards despite matters such as different levels of access to environmental resources, global warming and depleting fossil fuel resources. These themes are namely the provision of evolutionary explanation for religions, women’s rights, generating wealth in the form of living atmospheres, distributed workload across society and distributed food production. The following discussions illustrate how by changing the way we look at the world, utilizing our available but neglected resources, dreaming, believing, and acting, we can solve some of the most fundamental global problems. The provided solutions are protective of in idual freedoms, facilitate the convergence of lifestyles to a pleasant, practical, elegant, sustainable and modern model and protect the fabric of society as the foundation for higher-level achievements necessary for the maintenance and improvement of our living standards.
Publisher: IEEE
Date: 04-2013
Publisher: Institute of Electronics, Information and Communications Engineers (IEICE)
Date: 2011
DOI: 10.1587/ELEX.8.478
Publisher: Elsevier BV
Date: 07-2015
No related grants have been discovered for Omid Sadeghi Fathabadi.