ORCID Profile
0000-0003-1061-2441
Current Organisations
Flinders University
,
University of Otago
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Publisher: American Chemical Society (ACS)
Date: 28-09-2022
Publisher: MDPI AG
Date: 18-05-2023
Publisher: Wiley
Date: 14-03-2016
DOI: 10.1002/JRS.4903
Publisher: Elsevier BV
Date: 09-2020
Publisher: American Chemical Society (ACS)
Date: 30-06-2023
Publisher: American Chemical Society (ACS)
Date: 06-01-2021
Publisher: Informa UK Limited
Date: 19-06-2023
Publisher: Springer Science and Business Media LLC
Date: 13-05-2015
DOI: 10.1007/S00216-015-8742-Y
Abstract: Raman spectroscopy was used to investigate how the effect of pre-treatment protocols, with combinations of hydrochloric acid (HCl), sodium hypochlorite (NaOCl) and hydrogen peroxide (H2O2), for molar-incisor hypo-mineralisation (MIH) altered the penetration depth of polymer infiltrants (ICON, DMG, Hamburg, Germany). Furthermore, the effect on the structure of the MIH portions of the teeth with treatment is examined using multivariate analysis of spectra. It was found that pre-treatment protocols improved penetration depths. The structure of the MIH portion post-treatment appeared much closer to that of normal enamel suggesting a diminution of protein in the MIH region with treatment.
Publisher: IEEE
Date: 28-06-2021
Publisher: Wiley
Date: 13-07-2013
DOI: 10.1002/JRS.4344
Publisher: The Royal Society
Date: 04-2016
Publisher: Elsevier BV
Date: 02-2018
Publisher: Informa UK Limited
Date: 02-01-2015
Publisher: MDPI AG
Date: 26-03-2021
Publisher: Wiley
Date: 25-10-2023
DOI: 10.1002/JBMR.4928
Publisher: Springer Science and Business Media LLC
Date: 08-04-2016
Publisher: American Chemical Society (ACS)
Date: 18-06-2021
Publisher: Elsevier BV
Date: 05-2017
Publisher: Elsevier BV
Date: 03-2020
Publisher: American Chemical Society (ACS)
Date: 08-10-2018
Publisher: Elsevier BV
Date: 02-2021
Publisher: Elsevier BV
Date: 05-2021
Publisher: Wiley
Date: 31-05-2021
DOI: 10.1002/JRS.6161
Publisher: Elsevier BV
Date: 11-2022
Publisher: Elsevier BV
Date: 08-2013
Publisher: Elsevier BV
Date: 07-2015
Publisher: Wiley
Date: 17-09-2012
Publisher: American Chemical Society (ACS)
Date: 07-03-2014
DOI: 10.1021/JP411826S
Publisher: American Chemical Society (ACS)
Date: 15-02-2021
Publisher: American Chemical Society (ACS)
Date: 24-09-2018
Publisher: Wiley
Date: 13-03-2020
DOI: 10.1002/JRS.5867
Publisher: Wiley
Date: 21-09-2021
DOI: 10.1002/APP.51677
Publisher: American Chemical Society (ACS)
Date: 16-02-2021
Publisher: American Chemical Society (ACS)
Date: 23-04-2019
Publisher: American Chemical Society (ACS)
Date: 15-03-2022
Publisher: American Chemical Society (ACS)
Date: 12-04-2021
Publisher: American Chemical Society (ACS)
Date: 27-06-2019
Publisher: American Chemical Society (ACS)
Date: 16-09-2021
Publisher: American Chemical Society (ACS)
Date: 06-2022
Publisher: American Chemical Society (ACS)
Date: 16-11-2017
Publisher: Elsevier BV
Date: 03-2019
Publisher: Elsevier BV
Date: 05-2021
Publisher: Cambridge University Press (CUP)
Date: 2021
Publisher: Elsevier BV
Date: 2014
DOI: 10.1016/J.JSB.2013.11.006
Abstract: Dolphins show increased tooth number and simplified tooth shape compared to most mammals, together with a simpler ultrastructural organization and less demanding biomechanical function. However, it is unknown if these factors are also reflected in the chemical composition of their teeth. Here, the bulk chemical composition and elemental distribution in enamel and dentine of extant dolphins were characterized and interpreted using X-ray and spectroscopy techniques. Teeth of 10 species of Delphinida were analyzed by WDX, EDX and Raman spectroscopy. For most of the species s led, the mineral content was higher in enamel than in dentine, increasing from inner towards outer enamel. The transition from dentine to enamel was marked by an increase in concentration of the major components Ca and P, but also in Na and Cl. Mg decreased from dentine to enamel. Concentrations of Sr and F were often low and below detection limits, but F peaked at the outer enamel region for some species. Raman spectroscopy analyzes showed characteristics similar to carbonated hydroxyapatite, with the strongest peak for the phosphate PO4(3-) stretching mode at 960-961cm(-1). Dentine s les revealed a higher ersity of peaks representative of organic components and proteins than enamel. The similar distribution pattern and small variation in average concentration of major and minor elements in dentine and enamel of dolphins suggest that they are subject to strong physiological control. A clear trend of the elemental variations for all dolphin species s led suggests that the general pattern of tooth chemistry is conserved among the Mammalia.
Publisher: MDPI AG
Date: 25-04-2023
Publisher: Elsevier BV
Date: 03-2017
Publisher: Elsevier BV
Date: 02-2022
DOI: 10.1016/J.IJPHARM.2021.121446
Abstract: The influence of amino acids, other than leucine, in improving aerosolization of inhalable powders has not been widely explored. This detailed study focused on the use of methionine, another promising endogenous amino acid, in high dose spray-dried co-amorphous powders by investigating the influence of methionine proportion (0 - 20%
Publisher: Elsevier BV
Date: 2023
Publisher: Elsevier BV
Date: 2021
Publisher: Wiley
Date: 23-11-2018
Publisher: American Chemical Society (ACS)
Date: 04-09-2020
Publisher: American Chemical Society (ACS)
Date: 30-03-2021
Publisher: Wiley
Date: 07-03-2019
DOI: 10.1111/NPH.15725
Publisher: American Chemical Society (ACS)
Date: 18-10-2017
Publisher: Elsevier BV
Date: 03-2015
Publisher: American Chemical Society (ACS)
Date: 03-05-2022
Publisher: American Chemical Society (ACS)
Date: 28-06-2023
Publisher: MDPI AG
Date: 17-07-2023
Publisher: Wiley
Date: 16-01-2015
DOI: 10.1002/JRS.4635
Publisher: MDPI AG
Date: 15-07-2022
Publisher: Springer New York
Date: 2016
Publisher: American Chemical Society (ACS)
Date: 03-02-2020
Publisher: Wiley
Date: 29-09-2021
DOI: 10.1002/JRS.6258
Publisher: Springer New York
Date: 2016
Publisher: Wiley
Date: 24-06-2019
DOI: 10.1002/JRS.5648
Publisher: American Chemical Society (ACS)
Date: 06-02-2020
Publisher: MDPI AG
Date: 30-07-2020
DOI: 10.3390/PHARMACEUTICS12080715
Abstract: Different formulation techniques have been investigated to prepare highly aerosolizable dry powders to deliver a high dose of antibiotics to the lung for treating local infections. In this study, we investigated the influence of the co-amorphization of a model drug, kanamycin, with selected amino acids (valine, methionine, phenylalanine, and tryptophan) by co-spray drying on its aerosolization. The co-amorphicity was confirmed by thermal technique. The physical stability was monitored using low-frequency Raman spectroscopy coupled with principal component analysis. Except for the kanamycin-valine formulation, all the formulations offered improved fine particle fraction (FPF) with the highest FPF of 84% achieved for the kanamycin-methionine formulation. All the co-amorphous formulations were physically stable for 28 days at low relative humidity (25 °C/ % RH) and exhibited stable aerosolization. At higher RH (53%), even though methionine transformed into its crystalline counterpart, the kanamycin-methionine formulation offered the best aerosolization stability without any decrease in FPF. While further studies are warranted to reveal the underlying mechanism, this study reports that the co-amorphization of kanamycin with amino acids, especially with methionine, has the potential to be developed as a high dose kanamycin dry powder formulation.
Publisher: American Chemical Society (ACS)
Date: 04-04-2022
Publisher: The Company of Biologists
Date: 2015
DOI: 10.1242/JEB.124917
Publisher: Elsevier BV
Date: 11-2021
Start Date: 2020
End Date: 2023
Funder: Marsden Fund
View Funded Activity