ORCID Profile
0000-0001-6135-2163
Current Organisations
Leiden University Medical Center
,
Rivierduinen Eating Disorder Ursula
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Publications
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
Publisher: Springer Science and Business Media LLC
Date: 15-07-2019
Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?
Publisher: Wiley
Date: 12-07-2010
Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting
Publisher: Wiley
Date: 22-11-2010
Shared genetic risk between eating disorder‐ and substance‐use‐related phenotypes: Evidence from genome‐wide association studies
Publisher: Wiley
Date: 16-02-2020
DOI: 10.1111/ADB.12880
The Val66Met polymorphism of the BDNF gene in anorexia nervosa: New data and a meta-analysis
Publisher: Informa UK Limited
Date: 21-09-2011
DOI: 10.3109/15622975.2011.605470
Abstract: The Val66Met polymorphism (rs6265) of the BDNF gene is a non-synonymous polymorphism, previously associated with anorexia nervosa (AN). We genotyped rs6265 in 235 patients with AN and 643 controls. Furthermore, we performed a systematic review of all case-control and family-based studies testing this SNP in AN, and combined the results in a meta-analysis. The results of the case-control study were non-significant. For the meta-analysis, nine studies were identified (ncases = 2,767 ncontrols = 3,322, ntrios = 53) and included. Primarily, the analyses indicated an association with OR of 1.11 (P = 0.024) in the allelic contrast, and OR of 1.14 (P = 0.025) for the dominant effect of the Met allele. However, additional analyses revealed that the first published study (from those included in the meta-analysis) overly influenced the pooled effect size (possibly due to a phenomenon known as a winner's curse). When this case-control study was replaced by a trio study (ntrios = 293) performed on a largely overlapping s le, the effect size became smaller and non-significant, both for the allelic contrast (OR = 1.07, P = 0.156) and the dominant effect (OR = 1.07, P = 0.319). The quality of included studies was good and there was no significant heterogeneity across the effect sizes. Our analyses indicate that the BDNF Val66Met variant is not associated with AN at detectable levels.
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
Publisher: Elsevier BV
Date: 02-2022
Influence of Candidate Genes on Attention Problems in Children: A Longitudinal Study
Publisher: Springer Science and Business Media LLC
Date: 30-10-2010
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Publisher: Elsevier BV
Date: 12-2019
Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa
Publisher: American Psychiatric Association Publishing
Date: 09-2017
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease
Publisher: Springer Science and Business Media LLC
Date: 27-04-2020
Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches
Publisher: Elsevier BV
Date: 10-2019
Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
Publisher: Springer Science and Business Media LLC
Date: 25-07-2017
DOI: 10.1038/MP.2017.88
Abstract: Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML ( P =9.89 × 10 −6 ), and rs7700147, an intergenic variant ( P =2.93 × 10 −5 ). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.
Genetic Variation at the TPH2 Gene Influences Impulsivity in Addition to Eating Disorders
Publisher: Springer Science and Business Media LLC
Date: 14-12-2012
DOI: 10.1007/S10519-012-9569-3
Abstract: Genes are involved in eating disorders (EDs) and self-induced vomiting (SV), a key symptom of different types of EDs. Perfectionism and impulsivity are potential risk factors for EDs. TPH2 (tryptophan hydroxylase 2) SNP rs1473473 was previously associated with anorexia nervosa and EDs characterized by SV. Could perfectionism or impulsivity be underlying the association between rs1473473 and EDs? Genetic association between TPH2 SNP rs1473473 and perfectionism or impulsivity was first evaluated in a random control group (N = 512). The associations obtained in this control group were subsequently tested in a group of patients with an ED (N = 267). The minor allele of rs1473473 (OR = 1.49) was more frequent in impulsive controls, but also in impulsive patients with an ED (OR = 1.83). The largest effect was found in the patients with an ED characterized by SV (OR = 2.51, p = 0.02). Genetic variation at the TPH2 gene appeared to affect impulsivity which, in turn, might predispose to the SV phenotype.
Anorexia nervosa and the Val158Met polymorphism of the COMT gene
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 06-2012
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Related Funding Activities
No related grants have been discovered for Rita Slof-Op 't Landt.