ORCID Profile
0000-0003-0825-9327
Current Organisations
Duke University
,
University of Oviedo
,
VA Tennessee Valley Healthcare System
,
Vanderbilt University Medical Center
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Publisher: Springer Science and Business Media LLC
Date: 06-2019
Abstract: Some of the most well-celebrated constructions of metastable de Sitter vacua from string theory, such as the KKLT proposal, involve the interplay of gaugino condensation on a D7-brane stack and an uplift by a positive tension object. These constructions have recently been challenged using arguments that rely on the trace-reversed and integrated 10d Einstein equation. We give a critical assessment of such concerns. We first relate an integrated 10d Einstein equation to the extremization condition for a 10d-derived 4d effective potential. Then we argue how to obtain the latter from a 10d action which incorporates gaugino condensation in a (recently proposed) manifestly finite, perfect-square form. This effective potential is consistent with 4d supergravity and does not present obstacles for an uplifted minimum. Moreover, within standard approximations, we understand the uplift explicitly in one of the popular versions of the integrated 10d equation. Our conclusion is that de Sitter constructions of the KKLT type cannot be dismissed simply based on the integrated 10d equations considered so far.
Publisher: Springer Science and Business Media LLC
Date: 08-2018
Abstract: We study spontaneous gauge symmetry breaking and the Higgs mechanism in nonlocal field theories. Motivated by the level truncated action of string field theory, we consider a class of nonlocal field theories with an exponential factor of the d’Alembertian attached to the kinetic and mass terms. Modifications of this kind are known to make mild the UV behavior of loop diagrams and thus have been studied not only in the context of string theory but also as an alternative approach to quantum gravity. In this paper we argue that such a nonlocal theory potentially includes a ghost mode near the nonlocal scale in the particle spectrum of the symmetry broken phase. This is in sharp contrast to local field theories and would be an obstruction to making a simple nonlocal model a UV complete theory. We then discuss a possible way out by studying nonlocal theories with extra symmetries such as gauge symmetries in higher spacetime dimensions.
Publisher: Cold Spring Harbor Laboratory
Date: 02-01-2020
DOI: 10.1101/2020.01.02.893065
Abstract: Assessment of preclinical models of vascular disease are paramount in the successful translation of novel treatments. The results of these models have traditionally relied on 2-D histological methodologies. Light sheet fluorescence microscopy (LSFM) is an imaging platform that allows for 3-D visualization of whole organs and tissues. In this study, we describe an improved methodological approach utilizing LSFM for imaging of preclinical vascular injury models while minimizing analysis bias. The rat carotid artery segmental pressure-controlled balloon injury and mouse carotid artery ligation injury were performed. Arteries were harvested and processed for LSFM imaging and 3-D analysis, as well as for 2-D area histological analysis. Artery processing for LSFM imaging did not induce vessel shrinkage or expansion, and was reversible by rehydrating the artery, allowing for subsequent sectioning and histological staining a posteriori . By generating a volumetric visualization along the length of the arteries, LSFM imaging provided different analysis modalities including volumetric, area, and radial parameters. Thus, LSFM-imaged arteries provided more precise measurements compared to classic histological analysis. Furthermore, LSFM provided additional information as compared to 2-D analysis in demonstrating remodeling of the arterial media in regions of hyperplasia and periadventitial neovascularization around the ligated mouse artery. LSFM provides a novel and robust 3-D imaging platform for visualizing and quantifying arterial injury in preclinical models. When compared with classic histology, LSFM outperformed traditional methods in precision and quantitative capabilities. LSFM allows for more comprehensive quantitation as compared to traditional histological methodologies, while minimizing user bias associated with area analysis of alternating, 2-D histological artery cross-sections. A more reproducible and robust quantitation of vascular pathology in preclinical models is necessary to accelerate translational discovery. Current methodology to assess vascular disease has significant limitations. The methodology described herein employs a modern imaging modality, light sheet fluorescence microscopy (LSFM), to improve assessment of established preclinical vascular injury models. LSFM provides more comprehensive and precise analysis capabilities than classical histological approaches. Hence, LSFM applied to vascular research has the potential to drive new basic discoveries, and ultimately translation of novel therapies.
Publisher: Oxford University Press (OUP)
Date: 13-02-2020
DOI: 10.1093/CVR/CVAA037
Abstract: Assessment of preclinical models of vascular disease is paramount in the successful translation of novel treatments. The results of these models have traditionally relied on two-dimensional (2D) histological methodologies. Light sheet fluorescence microscopy (LSFM) is an imaging platform that allows for three-dimensional (3D) visualization of whole organs and tissues. In this study, we describe an improved methodological approach utilizing LSFM for imaging of preclinical vascular injury models while minimizing analysis bias. The rat carotid artery segmental pressure-controlled balloon injury and mouse carotid artery ligation injury were performed. Arteries were harvested and processed for LSFM imaging and 3D analysis, as well as for 2D area histological analysis. Artery processing for LSFM imaging did not induce vessel shrinkage or expansion and was reversible by rehydrating the artery, allowing for subsequent sectioning and histological staining a posteriori. By generating a volumetric visualization along the length of the arteries, LSFM imaging provided different analysis modalities including volumetric, area, and radial parameters. Thus, LSFM-imaged arteries provided more precise measurements compared to classic histological analysis. Furthermore, LSFM provided additional information as compared to 2D analysis in demonstrating remodelling of the arterial media in regions of hyperplasia and periadventitial neovascularization around the ligated mouse artery. LSFM provides a novel and robust 3D imaging platform for visualizing and quantifying arterial injury in preclinical models. When compared with classic histology, LSFM outperformed traditional methods in precision and quantitative capabilities. LSFM allows for more comprehensive quantitation as compared to traditional histological methodologies, while minimizing user bias associated with area analysis of alternating, 2D histological artery cross-sections.
Location: United States of America
Location: Hong Kong
Location: No location found
Location: United States of America
Location: United States of America
Location: United States of America
Location: United States of America
No related grants have been discovered for Pablo Soler.