ORCID Profile
0000-0002-5067-1940
Current Organisations
The University of Newcastle
,
University of California, San Diego
,
University of Sydney
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Publisher: Public Library of Science (PLoS)
Date: 23-04-2009
Publisher: Springer Science and Business Media LLC
Date: 20-02-2017
Publisher: Wiley
Date: 11-01-2012
Publisher: Wiley
Date: 11-01-2012
Publisher: Wiley
Date: 11-01-2012
Publisher: Wiley
Date: 11-01-2012
Publisher: Informa UK Limited
Date: 12-2012
Publisher: JSTOR
Date: 10-1995
DOI: 10.2307/2390254
Publisher: Springer Berlin Heidelberg
Date: 30-08-2013
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2022
Publisher: Wiley
Date: 11-01-2012
Publisher: Informa UK Limited
Date: 12-2012
Publisher: Elsevier BV
Date: 05-1997
Publisher: Informa UK Limited
Date: 12-2012
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 11-2023
Publisher: Informa UK Limited
Date: 12-2012
Publisher: Wiley
Date: 13-01-2016
DOI: 10.1111/JFB.12877
Abstract: Common carp Cyprinus carpio displaying proactive or reactive stress coping styles were acclimated to two environmental regimes (low oxygen and low temperature), and selected groups were tested for response to an inflammatory challenge (Escherichia coli lipopolysaccharide, LPS). Plasma glucose and lactate levels were measured, as were selected C. carpio-specific messenger (m)RNA transcript abundance, including cortisol receptor (CR), enolase (ENO), glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and interleukin-1-beta (IL1β) was measured in in idual whole brain s les. Basal levels (in sham injected fish held in normoxic conditions at 25° C) of plasma lactate and glucose differed between coping styles, being significantly lower in proactive in iduals. Both variables increased in response to LPS challenge, with the exception of plasma glucose in reactive fish held in hypoxia. Baseline levels of gene expression under control conditions were significantly different for GAPDH between behavioural phenotypes. The responses to experimental challenge were sometimes diametrically opposed between stress-coping styles in a transcript-specific manner. For CR and GAPDH, for ex le, the response to LPS injection in hypoxia were opposite between proactive and reactive animals. Proactive fish showed decreased CR and increased GAPDH, whereas reactive showed the opposite response. These results further highlight that screening for stress-coping styles prior to experiments in adaptive physiology can significantly affect the interpretation of data obtained. Further, this leads to a more finely tuned analytical output providing an improved understanding of variation in in idual responses to both environmental and inflammatory challenge.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 06-2019
Publisher: CABI
Date: 27-03-2023
Publisher: Wiley
Date: 12-2009
Publisher: Elsevier BV
Date: 06-1996
Publisher: O.I.E (World Organisation for Animal Health)
Date: 04-2014
Publisher: Elsevier BV
Date: 07-2008
Publisher: Springer Science and Business Media LLC
Date: 13-05-2011
Publisher: Wiley
Date: 05-2010
Publisher: Inter-Research Science Center
Date: 04-05-2007
DOI: 10.3354/DAO075173
Publisher: Springer Science and Business Media LLC
Date: 1997
DOI: 10.1007/BF02764786
Publisher: Springer Netherlands
Date: 2015
Publisher: Elsevier BV
Date: 2021
Publisher: Elsevier BV
Date: 1991
Publisher: Wiley
Date: 18-02-2022
DOI: 10.1002/ANA.26308
Abstract: The objective of this study was to evaluate novel plasma p‐tau231 and p‐tau181, as well as Aβ 40 and Aβ 42 assays as indicators of tau and Aβ pathologies measured with positron emission tomography (PET), and their association with cognitive change, in cognitively unimpaired older adults. In a cohort of 244 older adults at risk of Alzheimer's disease (AD) owing to a family history of AD dementia, we measured single molecule array (Simoa)‐based plasma tau biomarkers (p‐tau231 and p‐tau181), Aβ 40 and Aβ 42 with immunoprecipitation mass spectrometry, and Simoa neurofilament light (NfL). A subset of 129 participants underwent amyloid‐β ( 18 F‐NAV4694) and tau ( 18 F‐flortaucipir) PET assessments. We investigated plasma biomarker associations with Aβ and tau PET at the global and voxel level and tested plasma biomarker combinations for improved detection of Aβ‐PET positivity. We also investigated associations with 8‐year cognitive change. Plasma p‐tau biomarkers correlated with flortaucipir binding in medial temporal, parietal, and inferior temporal regions. P‐tau231 showed further associations in lateral parietal and occipital cortices. Plasma Aβ 42/40 explained more variance in global Aβ‐PET binding than Aβ 42 alone. P‐tau231 also showed strong and widespread associations with cortical Aβ‐PET binding. Combining Aβ 42/40 with p‐tau231 or p‐tau181 allowed for good distinction between Aβ‐negative and ‐positive participants (area under the receiver operating characteristic curve [AUC] range = 0.81–0.86). In iduals with low plasma Aβ 42/40 and high p‐tau experienced faster cognitive decline. Plasma p‐tau231 showed more robust associations with PET biomarkers than p‐tau181 in presymptomatic in iduals. The combination of p‐tau and Aβ 42/40 biomarkers detected early AD pathology and cognitive decline. Such markers could be used as prescreening tools to reduce the cost of prevention trials. ANN NEUROL 2022 :548–560
Publisher: Elsevier BV
Date: 03-2008
Publisher: Hindawi Limited
Date: 08-2007
Publisher: Elsevier BV
Date: 1996
Location: United States of America
No related grants have been discovered for Robert Bitmead.