ORCID Profile
0000-0001-8319-3626
Current Organisations
University of Twente
,
Medisch Spectrum Twente
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Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 2009
Publisher: Future Medicine Ltd
Date: 07-2011
DOI: 10.2217/FNL.11.28
Abstract: Evaluation of: Chollet F Tardy J, Albucher JF et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial. Lancet Neurol. 10(2), 123–130 (2011). In this study, the authors examined the effects of administration of fluoxetine for 90 days on the recovery of motor function in acute stroke patients. They found that motor function in the group receiving fluoxetine improved significantly compared with the control group. Before administration of fluoxetine can be used as a new therapeutic treatment to improve the rehabilitation after stroke, the long-term effects in chronic stroke patients, as well as the physiological effects, have to be studied and compared with the results of other neuropharmacalogical agents.
Publisher: Springer Science and Business Media LLC
Date: 16-06-2013
DOI: 10.1007/S00221-013-3571-8
Abstract: The activity of the brain during observation or imagination of movements might facilitate the relearning of motor functions after stroke. The present study examines whether there is an additional effect of imagination over observation-only. Eight healthy subjects observed and observed-and-imagined a movement of a hand 64-channel EEG was used to measure brain activity. The synchronization of the theta (4-8 Hz), alpha (8-13 Hz) and beta (13-25 Hz) frequency bands was calculated and plotted in topoplots. The temporal changes of the sensorimotor area (C3, C4) and the centro-parietal cortex (Pz) were analyzed in the two experimental conditions. During observation-and-imagination, a significant larger desynchronization (p = 0.004) in the sensorimotor area was found compared to observation-only in all electrodes and frequency bands. In addition, temporal differences were found between observation and observation-and-imagination in the alpha frequency bands. During observation-and-imagination, modulations of EEG rhythms were stronger than during observation-only in the theta, alpha and beta frequency bands and during almost the whole activity fragment. These findings suggest an additive effect of imagination to observation in the rehabilitation after stroke.
Publisher: Cold Spring Harbor Laboratory
Date: 03-11-2022
DOI: 10.1101/2022.11.02.514844
Abstract: Continuous EEG monitoring contributes to prediction of neurological outcome in comatose cardiac arrest survivors. While the phenomenology of EEG abnormalities in postanoxic encephalopathy is well-known, the pathophysiology, especially the presumed role of selective synaptic failure is less understood. To further this understanding, we estimate biophysical model parameters from the EEG power spectra from in idual patients with a good or poor recovery from a postanoxic encephalopathy. This biophysical model includes intracortical, intrathalamic, and corticothalamic synaptic strengths, as well as synaptic time constants and axonal conduction delays. We used continuous EEG measurements from hundred comatose patients recorded during the first 48 hours post-cardiac arrest, fifty with a poor neurological outcome (Cerebral Performance Category (CPC=5)) and fifty with a good neurological outcome (CPC=1). We only included patients that developed (dis-) continuous EEG activity within 48 hours post-cardiac arrest. For patients with a good outcome, we observed an initial relative excitation in the corticothalamic loop and corticothalamic propagation that subsequently evolved towards values observed in healthy controls. For patients with a poor outcome, we observed an initial increase in the cortical excitation-inhibition ratio, increased relative inhibition in the corticothalamic loop, delayed corticothalamic propagation of neuronal activity, and severely prolonged synaptic time constants, that did not return to physiological values. We conclude that the abnormal EEG evolution in patients with a poor neurological recovery after cardiac arrest may result from persistent and selective synaptic failure that includes corticothalamic circuitry, but also delayed corticothalamic propagation.
No related grants have been discovered for Michel van Putten.