ORCID Profile
0000-0001-9233-0338
Current Organisation
University of Illinois System
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Publisher: Elsevier
Date: 2010
Publisher: Elsevier BV
Date: 2016
Publisher: Public Library of Science (PLoS)
Date: 20-08-2020
Publisher: CRC Press
Date: 19-08-2016
Publisher: American Veterinary Medical Association (AVMA)
Date: 07-2019
Publisher: Wiley
Date: 26-03-2015
DOI: 10.1111/AVJ.12302
Abstract: Apply a previously described scoring system retrospectively to cases of canine primary immune-mediated haemolytic anaemia (pIMHA) to determine its accuracy and reliability for the determination of prognosis in Victoria, Australia. Retrospective cohort study of 41 dogs diagnosed with pIMHA at the University of Melbourne Veterinary Hospital (UMVH) between August 2006 to December 2012. Of the 41 dogs included, 70.7% were female while 29.3% were male. The overall mortality in this study was 43.9%. The previously described prognostic scoring system when applied to cases of pIMHA in Victoria, Australia, was not found to show statistical significance for prognostification. None of the five prognostic factors were found to be independently significant for prognostification. Application of the previously described prognostic scoring system indicated that it may not be reliable for predicting prognoses of dogs with pIMHA in Victoria, Australia.
Publisher: Wiley
Date: 19-10-2013
Publisher: Wiley
Date: 06-05-2019
DOI: 10.1111/VCP.12732
Abstract: Two adult male dogs (a 7-year-old shorthaired Chihuahua and 14-year-old Shih Tzu) and one adult female dog (a 9-year-old Maltese) presented for evaluation of new-onset seizure activity. Magnetic resonance imaging of the brain demonstrated a large, poorly marginated T2-weighted hyperintense, and strong contrast enhancing extra-axial mass in each case. A surgical biopsy for histopathologic evaluation was elected in all cases, and intraoperative impression smears were successfully obtained. Intraoperative cytology identified a homogenous population of round to polygonal cells with central to eccentric nuclei, coarse chromatin, and variably hophilic to eosinophilic granular cytoplasm. Cytologic findings led to a suspected diagnosis of granular cell tumor (GCT) in all cases. Histopathologic review identified a densely cellular, unencapsulated neoplastic mass comprised of sheets of large round to polygonal cells with abundant eosinophilic cytoplasm containing numerous eosinophilic intracytoplasmic granules, confirming the diagnosis of GCT in all cases. The cases reported here are unique in that they reveal an accurate intraoperative cytologic diagnosis of a rare canine central nervous system neoplasm. Intraoperative cytology of the intracranial masses could provide clinicians with important and quick diagnostic and prognostic information therefore, expediting decisions made intraoperatively. Further research is warranted to determine the diagnostic accuracy of intraoperative cytology for neoplasia in veterinary patients.
Publisher: SAGE Publications
Date: 23-12-2014
Abstract: Free-roaming cats in New York, NY, USA, that presented to a trap–neuter–return program were surveyed for biochemical data. One hundred and one cats had blood collected for a plasma biochemistry panel after the induction of surgical anesthesia. Reference intervals for 18 analytes were generated for the s le population, along with age-specific reference intervals when statistically appropriate. Age groups (juveniles and adults) differed in 10 of the 18 analytes measured, including protein levels and albumin/globulin ratio, aspartate aminotransferase, alkaline phosphatase, creatine kinase, creatinine, phosphorus, calcium and potassium. No differences were found between males and females. This is the first report of biochemical reference intervals for a group of free-roaming cats within the USA.
Publisher: Wiley
Date: 11-11-2018
DOI: 10.1111/VCP.12671
Abstract: Perianal (hepatoid) gland tumors are common in dogs, and the distinction between the benign and malignant forms is clinically important. Cytology of these tumors typically contains many large hepatoid cells and fewer small basal cells. The objective of this study was to determine whether the proportion of the smaller basaloid reserve cells in cytologic s les from perianal tumors correlates with malignancy. Eighty-three cases of cytologically diagnosed perianal gland tumors with corresponding histopathologic sections were identified from two separate institutions and included six (7.2%) malignant tumors and 77 (92.8%) benign tumors. The proportion of basal cells from each s le was evaluated. No difference between these groups was found, although the study was sufficiently powered to detect an approximately 1.5-fold change in basal cell proportion. This report found no evidence that the proportion of basal cells in canine perianal tumor cytology is an indication of the potential for malignancy. We, therefore, do not recommend citing this feature in cytologic reports or when communicating with clinicians.
Publisher: Wiley
Date: 16-05-2022
DOI: 10.1111/VCP.13123
Abstract: Canine C-reactive protein (cCRP) is an acute-phase protein that increases dramatically with inflammation and has potential utility in monitoring disease progression and response to treatment. Rapid, automated point-of-care test (POCT) formats could enhance the clinical utility of cCRP measurement. We aimed to evaluate the VetChroma canine-specific POCT assay for the quantitative measurement of cCRP in canine serum or plasma. Serum and plasma from discarded canine diagnostic s les were used. Evaluation included intra- and inter-assay coefficients of variation and observed total error (TE Intra-assay variation ranged from 2.5%-6.1%, and inter-assay variation ranged from 2.1%-5.4%. The TE The VetChroma cCRP assay has acceptable test performance to measure serum cCRP concentration. The POCT protocol and test kit are valid for clinical use, although results obtained using other cCRP assays or plasma may not be directly compared.
Publisher: Wiley
Date: 09-2021
DOI: 10.1111/VCP.13010
Abstract: Blood gas chemistry analyzers typically produce results faster and use smaller s le volumes than reference chemistry analyzers. However, results may not be comparable between blood gas chemistry analyzers and reference chemistry analyzers or between different models of blood gas chemistry analyzers. This could suggest the use of separate reference intervals and, thus, has implications when making clinical decisions. We aimed to perform method comparison studies to evaluate selected canine serum biochemical values obtained using the Nova Stat Profile Prime Plus VET (Prime Plus VET), Stat Profile Nova pHOx Ultra (Ultra), and Beckman Coulter AU680 (Beckman) analyzers. We hypothesized that the three analyzers would be identical within inherent imprecision. Jugular venous blood s les were collected from 103 endurance‐trained sled dogs, and serum was harvested and stored for analysis. Results for serum chloride, potassium, sodium, creatinine, and urea nitrogen concentrations obtained from the Prime Plus VET and Ultra analyzers were compared with results from the Beckman analyzer, which was considered to be a reference method. Results for serum chloride, potassium, sodium, creatinine, urea nitrogen, and L‐lactate concentrations obtained from the Prime Plus VET and Ultra analyzers were compared. Passing‐Bablok regression and Bland‐Altman plots were used for method comparison. Significant ( P 0.05) constant or proportional bias was found for many analytes for all three method comparison studies. Due to the presence of statistically significant differences between all three analyzers that may be clinically relevant, it is recommended that reference intervals be created for new blood gas analyzers, even when similar methodologies are used.
No related grants have been discovered for Sara Connolly.