ORCID Profile
0000-0002-0909-1506
Current Organisation
University of Pittsburgh Graduate School of Public Health
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Publications
Multimodal MRI markers support a model of small vessel ischemia for depressive symptoms in very old adults
Publisher: Elsevier BV
Date: 11-2014
White Matter Hyperintensity Burden and Disability in Older Adults: Is Chronic Pain a Contributor?
Publisher: Wiley
Date: 07-03-2013
Psychomotor Speed and Functional Brain MRI 2 Years After Completing a Physical Activity Treatment
Publisher: Oxford University Press (OUP)
Date: 26-03-2010
Correlates of Gait Speed Among Older Adults From 6 Countries: Findings From the COSMIC Collaboration
Publisher: Oxford University Press (OUP)
Date: 28-03-2023
Abstract: Few studies have compared gait speed and its correlates among different ethnogeographic regions. The goals of this study were to describe usual and rapid gait speed, and identify their correlates across Australian, Asian, and African countries. We used data from 6 population-based cohorts of adults aged 65+ from 6 countries and 3 continents (N = 6 472), with s les ranging from 231 to 1 913. All cohorts are members of the Cohort Studies of Memory in an International Consortium collaboration. We investigated whether clinical (body mass index [BMI], hypertension, stroke, apolipoprotein status), psychological (cognition, mood, general health), and behavioral factors (smoking, drinking, physical activity) correlated with usual (N = 4 cohorts) and rapid gait speed (N = 3 cohorts) similarly across cohorts. Regression models were controlled for age, sex, and education, and were sex-stratified. Age- and sex-standardized usual gait speed means ranged from 0.61 to 1.06 m/s and rapid gait speed means ranged from 1.16 to 1.64 m/s. Lower BMI and better cognitive function consistently correlated with faster gait speed in all cohorts. Less consistently, not having hypertension and greater physical activity engagement were associated with faster gait speed. Associations with mood, smoking, and drinking were largely nonsignificant. These patterns were not attenuated by demographics. There was limited evidence that the associations differed by sex, except physical activity, where the greater intensity was associated with usual gait among men but not women. This study is among the first to describe the usual and rapid gait speeds across older adults in Africa, Asia, and Australia.
Executive control function, brain activation and white matter hyperintensities in older adults
Publisher: Elsevier BV
Date: 02-2010
Aortic Pulse Wave Velocity Predicts Focal White Matter Hyperintensities in a Biracial Cohort of Older Adults
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 2013
DOI: 10.1161/HYPERTENSIONAHA.112.198069
Abstract: Although the cross-sectional relationship of arterial stiffness with cerebral small vessel disease is consistently shown in middle-aged and young-old adults, it is less clear whether these associations remain significant over time in very old adults. We hypothesize that arterial stiffness is longitudinally associated with white matter characteristics, and associations are stronger within watershed areas. Neuroimaging was obtained in 2006–2008 from 303 elderly (mean age 82.9 years, 59% women, 41% black) with pulse wave velocity (PWV) measures in 1997–1998. Multivariable regression models estimated the coefficients for PWV (cm/sec) in relationship to presence, severity, and spatial distribution of white matter hyperintensities (WMH), gray matter volume, and fractional anisotropy from diffusion tensor, adjusting for demographic, cardiovascular risk factors, and diseases from 1997–1998 to 2006–2008. Higher PWV in 1997–1998 was associated with greater WMH volume in 2006–2008 within the left superior longitudinal fasciculus (age and total brain WMH adjusted, P =0.023), but not with WMH in other tracts or with fractional anisotropy or gray matter volume from total brain ( P .2). Associations were stronger in blacks than in whites, remaining significant in fully adjusted models. Elderly with WMH in tracts related to processing speed and memory are more likely to have had higher PWV values 10 years prior, before neuroimaging data being available. Future studies should address whether arterial stiffness can serve as an early biomarker of covert brain structural abnormalities and whether early arterial stiffness control can promote successful brain aging, especially in black elderly.
Neuroimaging differences between older adults with maintained versus declining cognition over a 10-year period
Publisher: Elsevier BV
Date: 08-2012
Corrigendum to “Executive control function, brain activation and white matter hyperintensities in older adults” [NeuroImage 49 (2010) 3436–3442]
Publisher: Elsevier BV
Date: 05-2010
Patterns of Focal Gray Matter Atrophy Are Associated With Bradykinesia and Gait Disturbances in Older Adults
Publisher: Oxford University Press (OUP)
Date: 24-02-2012
Lower Digit Symbol Substitution Score in the Oldest Old is Related to Magnetization Transfer and Diffusion Tensor Imaging of the White Matter
Publisher: Frontiers Media SA
Date: 2011
Related Organisations
University Of Pittsburgh Medical Center
Location: United States of America
University Of Pittsburgh Graduate School Of Public Health
Location: United States of America
University Of Miami School Of Medicine
Location: United States of America
Related Funding Activities
No related grants have been discovered for Caterina Rosano.