ORCID Profile
0000-0002-4607-5791
Current Organisation
University of Southampton
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Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3CC44841J
Abstract: The formation of tren-based tris-urea supramolecular gels in organic solvents is perturbed by the presence of the nerve agent soman providing a new method of sensing the presence of organophosphorus warfare agents.
Publisher: American Chemical Society (ACS)
Date: 27-01-2015
DOI: 10.1021/JA510063N
Abstract: We report a dynamic covalent approach to transmembrane transport of amino acids by the formation of a three-component assembly. A mixture of a squaramide and a lipophilic and electrophilic aldehyde is shown to synergistically transport highly polar glycine (Gly) across vesicle membranes. The transport was investigated by a (13)C NMR assay, an osmotic response assay, a newly developed fluorescence assay suitable for measuring Gly influx, and other fluorescence assays for leakage and pH change. The transport is proposed to occur via a hydrogen-bonded anionic glycine hemiaminal/imine, accompanied by transport of OH(-) in the opposite direction. Several control experiments support the role of hemiaminal/imine in the observed facilitated Gly transport. Proton NMR studies of a biphasic system show the presence of both the hemiaminal and imine formed between Gly and an aldehyde. Interestingly, the synergistic effect has also been observed for sarcosine, which can form hemiaminals but not imines. The results demonstrate the potential of hemiaminal formation for the facilitated transport of substrates containing primary and secondary amino groups.
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2OB26299A
Abstract: The influence of anions on tautomerism in benzimidazole containing anion receptors has been studied via a variety of techniques in both solution and the solid state. The results show that hydrogen bonding interactions between the receptors and guests have a significant effect of the nature of the tautomer present. The compounds show a preference for complexation of lactate over pyruvate.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5SC01864A
Abstract: A series of supramolecular diamide organogels containing a reactive compound for the remediation of organophosphorus (OP) species, in particular OP chemical warfare agents (CWAs), has been prepared in DMSO.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4CC05519E
Abstract: Simple, highly fluorinated receptors are shown to function as effective transmembrane anion transporters with the most active transporters rivalling the transport efficacy of natural anion transporter prodigiosin for chloride/bicarbonate antiport.
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C1OB06800H
Abstract: Tautomeric switching is observed in a series of benzimidazole-based anion receptors upon addition of basic anions. An N-methylbenzimidazole based receptor selectively interacts with dihydrogen phosphate over a variety of other putative anionic guests via a combination of donated and accepted hydrogen bonds.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4TA04834B
Abstract: The chemical warfare agent (CWA) soman (GD) acts as a molecular stimulus for the disruption of an anthracene-based binary organogel prepared in cyclohexane.
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3SC51023A
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3SC52006D
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4CC00333K
Abstract: A series of low molecular weight tripodal amide/histidine-containing compounds have been synthesised and shown to increase the rate of bis-( p -nitrophenyl) phosphate (BNPP) and soman (GD) breakdown in buffered aqueous solution.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C3OB41522H
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C2CC38198B
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Neil Wells.