ORCID Profile
0000-0002-5403-6880
Current Organisation
Beijing Institute of Technology
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Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC02097D
Abstract: By utilizing a pH-responsive ratiometric AIEgen, dihydro berberine (dhBBR), ion trapping phenomenon was successfully visualized.
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1SC06336G
Abstract: A novel bioconjugatable and photostable AIE luminogen has been rationally synthesized for precise and long-term tracking of neuron mitochondria.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM00877J
Abstract: We present a two-photon AIEgen, ABCXF with nonaromatic rotors (–CF 3 ), a high two-photon absorption cross-section, bright red emission in the solid-state, and remarkably high photostability for fatty liver disease diagnosis.
Publisher: American Chemical Society (ACS)
Date: 18-04-2018
DOI: 10.1021/ACSSENSORS.7B00820
Abstract: In this work, a benzothiazole-based aggregation-induced emission luminogen (AIEgen) of 2-(5-(4-carboxyphenyl)-2-hydroxyphenyl)benzothiazole (3) was designed and synthesized, which exhibited multifluorescence emissions in different dispersed or aggregated states based on tunable excited-state intramolecular proton transfer (ESIPT) and restricted intramolecular rotation (RIR) processes. 3 was successfully used as a ratiometric fluorescent chemosensor for the detection of pH, which exhibited reversible acid/base-switched yellow/cyan emission transition. More importantly, the pH jump of 3 was very precipitous from 7.0 to 8.0 with a midpoint of 7.5, which was well matched with the physiological pH. This feature makes 3 very suitable for the highly sensitive detection of pH fluctuation in bios les and neutral water s les. 3 was also successfully used as a ratiometric fluorescence chemosensor for the detection of acidic and basic organic vapors in test papers.
Publisher: American Chemical Society (ACS)
Date: 24-07-2023
Publisher: American Chemical Society (ACS)
Date: 31-05-2019
Abstract: In clinical studies, thiol measurement in the whole blood is of diagnostic and prognostic significance. In addition, the detection of mitochondrial thiol is very important for investigating cellular functions or dysfunctions. Here, a ratiometric aggregation-induced emission luminogen (AIEgen) called TPE-PBP for thiol detection was developed by introducing a
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC01213K
Abstract: We present a series of AIEgens for cancer cell discrimination and dynamic viability monitoring.
Publisher: American Chemical Society (ACS)
Date: 16-11-2020
Abstract: Photodynamic therapy (PDT), a noninvasive therapeutic strategy for cancer treatment, which always suffers from the low reactive oxygen species (ROS) yield of traditional organic dyes. Herein, we present lipid-encapsulated aggregation-induced emission nanoparticles (AIE NPs) that have a high quantum yield (23%) and a maximum two-photon absorption (TPA) cross-section of 560 GM irradiated by near-infrared light (800 nm). The AIE NPs can serve as imaging agents for spatiotemporal imaging of tumor tissues with a penetration depth up to 505 μm on mice melanoma model. Importantly, the AIE NPs can simultaneously generate singlet oxygen (
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TC04106K
Abstract: Light scattering and absorption both contribute to the UV-vis extinction quantified with a UV-vis spectrophotometer, but they differ drastically in their causes and effects.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9SC06226B
Abstract: An AIE-active ratiometric probe for the first time achieved the long-term quantification of lysosomal pH during the medaka larva's caudal fin regeneration.
Publisher: American Chemical Society (ACS)
Date: 02-07-2018
Publisher: American Chemical Society (ACS)
Date: 24-02-2023
Publisher: American Chemical Society (ACS)
Date: 22-08-2019
DOI: 10.1021/JACS.9B06196
Abstract: Acrylonitriles with aggregation-induced emission (AIE) characteristics have been found to show promising applications in two-photon biomedical imaging. Generally, elaborate synthetic efforts are required to achieve different acrylonitriles with distinct functionalities. In this work, we first reported the synthesis of two different group-functionalized AIE-active acrylonitriles (TPAT-AN-XF and 2TPAT-AN) obtained simply by mixing the same reactants at different temperatures using a facile and transition metal-free synthetic method. These two AIE luminogens (AIEgens) exhibit unique properties such as bright red emission in the solid state, large Stokes shift, and large two-photon absorption cross section. Water-soluble nanoparticles (NPs) of 2TPAT-AN were prepared by a nanoprecipitation method. In vitro imaging data show that 2TPAT-AN NPs can selectively stain lysosome in live cells. Besides one-photon imaging, remarkable two-photon imaging of live tumor tissues can be achieved with high resolution and deep tissue penetration. 2TPAT-AN NPs show high biocompatibility and are successfully utilized in in vivo long-term imaging of mouse tumors with a high signal-to-noise ratio. Thus, the present work is anticipated to shed light on the preparation of a library of AIE-active functionalized acrylonitriles with intriguing properties for biomedical applications.
Publisher: American Chemical Society (ACS)
Date: 30-01-2020
DOI: 10.1021/JACS.9B12936
Abstract: New agents with particular specificity toward targeted bacteria and superefficacy in antibacterial activity are urgently needed in facing the crisis of worldwide antibiotic resistance. Herein, a novel strategy by equipping bacteriophage (PAP) with photodynamic inactivation (PDI)-active AIEgens (luminogens with aggregation-induced emission property) was presented to generate a type of AIE-PAP bioconjugate with superior capability for both targeted imaging and synergistic killing of certain species of bacteria. The targeting ability inherited from the bacteriophage enabled the bioconjugates to specifically recognize the host bacteria with preserved infection activity of phage itself. Meanwhile, the AIE characteristic empowered them a monitoring functionality, and the real-time tracking of their interactions with targets was therefore realized via convenient fluorescence imaging. More importantly, the PDI-active AIEgens could serve as powerful in situ photosensitizers producing high-efficiency reactive oxygen species (ROS) under white light irradiation. As a result, selective targeting and synergistic killing of both antibiotic-sensitive and multi-drug-resistant (MDR) bacteria were successfully achieved in in vitro and in vivo antibacterial tests with excellent biocompatibility. This novel AIE-phage integrated strategy would ersify the existing pool of antibacterial agents and inspire the development of promising drug candidates in the future.
No related grants have been discovered for Guangle Niu.