ORCID Profile
0000-0002-1816-990X
Current Organisation
Universitas Andalas
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Publisher: International Journal of Pharmaceutical Sciences and Research
Date: 10-2019
Publisher: EManuscript Technologies
Date: 07-09-2019
Publisher: International Pharmaceutical Federation (FIP)
Date: 15-05-2023
DOI: 10.46542/PE.2023.232.1924
Abstract: Background: Catechins are good free radical scavengers but exhibit low stability and permeability. Nanophytosomes are currently being developed as the delivery system for phytoconstituents to protect them from decomposition by oxidants or enzymes and increase their permeability. Objectives: To formulate gambier catechin-loaded nanophytosomes and perform the MTT assay on HeLa cell lines. Method:Five formulations were prepared using soya lecithin at various molar ratios of cholesterol by thin-layer hydration and sonication. The nanophytosomes were characterised by the determination of vesicle size, zeta potential, polydispersity index, morphology with Transmission Electron Microscope, Fourier Transform Infrared Spectroscopy (FT-IR) analysis, freeze and thaw test, entrapment efficiency, and the in vitro cytotoxicity test. Result: The optimal formula (F4) with a molar ratio of 1:1:0.8 (catechin:lecithin:cholesterol) resulted in spherical vesicles with an average size (106 ± 0.218) nm, zeta potential -68 mV, polydispersity index 0.412, 93.5% entrapment efficiency and that were stable to temperature changes. FT-IR showed the formation of catechins and lecithin complexes. The activity of catechin-loaded nanophytosomes against HeLa cells showed an IC50 of 36.307 g/ml. There was a significant difference in the average percentage of cells undergoing apoptosis in all treatment groups (p 0.05). Conclusion: Catechin-loaded nanophytosomes with a molar ratio of 1:1:0.8 (catechin:lecithin:cholesterol) showed moderate cytotoxic activity against HeLa cell lines.
Publisher: MDPI AG
Date: 07-12-2022
DOI: 10.3390/PHARMACEUTICS14122741
Abstract: If it can be effectively delivered to its site of action, α-mangostin has potential in development of novel cosmeceuticals due to its melanogenesis-blocking activity. The aim of this study was to develop an ultra-small unilamellar carrier system for α-mangostin and to evaluate its effect as an anti-age-spot serum on humans in vivo. The ultra-small unilamellar carrier bases were optimized using a 25 factorial design, with five factors (virgin coconut oil, soy lecithin, Tween 80, and stirring duration and speed) and two levels (low and high) response of droplet size was analyzed using Design Expert 12®. The anti-spot examination was conducted via capturing digital images of the human skin after topical application of an α-mangostin-loaded ultra-small unilamellar carrier at night for two consecutive weeks. The results thereof were analyzed using Motic Live Imaging 3.0 and a standard red, green, and blue score. The optimized serum formula was confirmed with a composition of 2.3% virgin coconut oil, 1% lecithin, and 28.3% Tween 80 (polysorbate 80) at a stirring speed of 1500 revolutions per minute for 15 min. Incorporation of 3% α-mangostin to the optimized base formula produced an ultra-small unilamellar carrier globule size of 16.5 nm, with zeta potential of −25.8 mV and a polydispersion index of 0.445. Physical characterization of an α-mangostin-loaded ultra-small unilamellar carrier comprised 90.94% transmittance, a pH value of 6.5, a viscosity of 38 cP, specific gravity of 1.042 g/mL and 72.46% entrapment efficiency. A transmission electron microscope confirmed spherical nanosized droplets in the system. Topical application of an α-mangostin-loaded ultra-small unilamellar carrier at night for 2 consecutive weeks demonstrated anti-age-spot activity shown through a significant reduction in intensity and area of spots in human volunteers (p 0.05).
Publisher: Medknow
Date: 2019
Publisher: Wiley
Date: 25-05-2023
Abstract: Fenofibric acid is a poorly water‐soluble drug with high permeability thus, it is classified as a Biopharmaceutical Classification System (BCS) class II. This study aimed to prepare a eutectic mixture of fenofibric acid with syringic acid as a coformer to improve its solubility, dissolution rate, and antihyperlipidemic activity. The solvent co‐evaporation method was used to form a eutectic mixture. Solid‐state properties were characterized, solubility and in vitro dissolution profiles were studied, and in vivo antihyperlipidemic effectiveness was investigated in male Wistar rats. The results showed that the eutectic mixture of fenofibric acid‐syringic acid enhanced the solubility (3.4‐fold) and in vitro dissolution rate (3.62‐fold) and significantly improved the antihyperlipidemic activity compared with intact fenofibric acid.
Publisher: Universitas Padjadjaran
Date: 30-10-2020
DOI: 10.24198/IJPST.V7I3.26403
Abstract: Several studies have shown that pure compounds from west sumatera medicinal plants have beneficial therapeutic effects so that they are potential candidates for active pharmaceutical ingredients (API). Andalas Sitawa Fitolab has been able to produce 10 pure isolates. The development of a new drug candidate requires an in silico study to predict physicochemical properties, potential target, and toxic properties. The purpose of this study was to initially screen the structure of candidates to predict the potential the compound as an API by using big data and machine learning. The chemical structure were analyzed using software and servers. The Software used was Marvin Sketch, QSAR Toolbox, Swiss Potential Target and ChemBioDraw. Results showed that log P of compounds revealed in a range of -0.54 to 4.64, Polar Surface Area (PSA) in range of 20.23 to 315.21. Asiaticoside did not meet Lipinski's rules. Compounds with high potential hazard were catechin, curcumin, andrographolide, asiaticoside deoxyelephantopin, ethylmethoxycinnamate, alpha-mangostin and piperine. The compounds such as curcumin, alpha mangostin, plumbagin, and piperine were predicted to have spesific target proteins. This study concluded that asiaticoside compounds have a high potential hazard, if it was developed as an API.Keywords: analysis of physical-chemical properties, in silico, pure isolate, toxicology
Publisher: Elsevier BV
Date: 07-2000
DOI: 10.1016/S0378-5173(00)00413-0
Abstract: The kinetics of the reaction of sulfamethoxazole (SMX) in 5% w/v glucose to form the corresponding alpha- and beta-glucosylamines over the pH range of 0.80-6.88 at 37 degrees C has been investigated. The identity of the glucosylamines was determined by 1H-nuclear magnetic resonance spectroscopy of an authentic s le of the alpha-glucosylamine (USP) and the reaction products, and by interconversion of this compound to the corresponding beta-anomer. The reaction followed pseudo first-order reversible kinetics and involved specific acid and general acid-base catalysis. The pH-rate profile demonstrated that over the pH range of 0.80-2.90 and 5.50-6. 88 the reactions were dependent on H(+) concentration but pH independent between pH 3.00-5.45, which reflects the influence of ionization of SMX and the glucosylamines on the reversible reaction. Interpretation of the data with respect to kinetic models and rate equations for the formation and hydrolysis of the glucosylamines was investigated. Temperature dependence studies followed the Arrhenius equation with an Ea of 49.28 kJ mol(-1) for the forward and 63.46 kJ mol(-1) for the reverse reaction at pH 2.89 respectively.
Publisher: International Pharmaceutical Federation (FIP)
Date: 31-03-2022
DOI: 10.46542/PE.2022.222.132137
Abstract: Background: Flunarizine dihydrochloride is an antivertigo, antimigraine, and adjunctive therapy for epilepsy, available in Indonesia as tablets. However, the dissolution test for the tablet dosage forms is not yet available in the Pharmacopoeia. Objectives: To develop and validate the dissolution method of flunarizine dihydrochloride in tablets. Methods: The dissolution profiles of three products were determined using three media (HCl 0.1N, acetate buffer pH 4.5, and 0.2% Tween 80 solution) two apparatus (basket and paddle) at three agitation speeds (50, 75, and 100rpm). The amount of drug released per unit time was measured by a validated High Performance Liquid Chromatography system. Results: The method using a paddle apparatus at 50rpm in 900mL of 0.1N HCl medium was better hyperdiscriminating with a Q30 value ≥ 75% (p 0.05). The selected method met the acceptance criteria in terms of precision, accuracy, and specificity.
Publisher: Oriental Scientific Publishing Company
Date: 25-06-2018
DOI: 10.13005/OJC/340355
Publisher: Rasayan Journal of Chemistry
Date: 2019
No related grants have been discovered for Henny Lucida.