ORCID Profile
0000-0001-7647-1317
Current Organisations
Fudan University
,
Vanderbilt University Medical Center
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Publisher: American Chemical Society (ACS)
Date: 10-2020
Publisher: American Chemical Society (ACS)
Date: 05-08-2020
DOI: 10.1021/JACS.0C07193
Publisher: Elsevier BV
Date: 05-2019
DOI: 10.1016/J.CELL.2019.03.018
Abstract: Innate immune responses are intricately linked with intracellular metabolism of myeloid cells. Toll-like receptor (TLR) stimulation shifts intracellular metabolism toward glycolysis, while anti-inflammatory signals depend on enhanced mitochondrial respiration. How exogenous metabolic signals affect the immune response is unknown. We demonstrate that TLR-dependent responses of dendritic cells (DCs) are exacerbated by a high-fatty-acid (FA) metabolic environment. FAs suppress the TLR-induced hexokinase activity and perturb tricarboxylic acid cycle metabolism. These metabolic changes enhance mitochondrial reactive oxygen species (mtROS) production and, in turn, the unfolded protein response (UPR), leading to a distinct transcriptomic signature with IL-23 as hallmark. Interestingly, chemical or genetic suppression of glycolysis was sufficient to induce this specific immune response. Conversely, reducing mtROS production or DC-specific deficiency in XBP1 attenuated IL-23 expression and skin inflammation in an IL-23-dependent model of psoriasis. Thus, fine-tuning of innate immunity depends on optimization of metabolic demands and minimization of mtROS-induced UPR.
Publisher: Wiley
Date: 04-06-2020
Publisher: American Chemical Society (ACS)
Date: 14-02-2022
Abstract: Although molecular design strategies for highly bright near-infrared II (NIR-II) fluorophores were proposed, the lack of solid structural identification (single crystal) hinders the further development of this field. This thorny issue is addressed by performing the structure-function relationship of NIR-II dyes, as confirmed by molecular single crystal engineering. Single crystal structure analysis confirms that twisted architectures (large dihedral angles ∼70°) and loose packing patterns (intermolecular distance of ∼3.4-4.5 Å) are key elements to enhance the absolute quantum yield (QY) in the solid state. Through regulating donor-acceptor distance and donor-acceptor interactions, the resultant well-defined TBP-
Location: United States of America
No related grants have been discovered for Xuefeng Lu.