ORCID Profile
0000-0001-7680-7773
Current Organisations
Guangzhou Medical University
,
Centre National de la Recherche Scientifique
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Publisher: American Association for the Advancement of Science (AAAS)
Date: 17-07-2009
Abstract: Drosophila melanogaster is an important model system to study innate immunity, being both easy to manipulate and lacking an adaptive immune system. In order to identify genes that regulate innate immunity, Cronin et al. (p. 340 published online 11 June) performed an RNA interference screen on flies infected with the oral bacterial pathogen, Serratia marcescens . Genes involved in intestinal immunity and regulation of hemocytes, macrophage-like cells critical for phagocytosis and killing of the bacteria, were identified. Several hundred genes conferred either enhanced susceptibility or resistance to bacterial infection. Furthermore, the JAK/STAT signaling pathway was activated in intestinal stem cells after bacterial infection, resulting in enhanced susceptibility to infection, most likely through regulation of intestinal stem cell homeostasis.
Publisher: Elsevier BV
Date: 2010
DOI: 10.1016/J.CELL.2009.12.027
Abstract: Over 1 billion people are estimated to be overweight, placing them at risk for diabetes, cardiovascular disease, and cancer. We performed a systems-level genetic dissection of adiposity regulation using genome-wide RNAi screening in adult Drosophila. As a follow-up, the resulting approximately 500 candidate obesity genes were functionally classified using muscle-, oenocyte-, fat-body-, and neuronal-specific knockdown in vivo and revealed hedgehog signaling as the top-scoring fat-body-specific pathway. To extrapolate these findings into mammals, we generated fat-specific hedgehog-activation mutant mice. Intriguingly, these mice displayed near total loss of white, but not brown, fat compartments. Mechanistically, activation of hedgehog signaling irreversibly blocked differentiation of white adipocytes through direct, coordinate modulation of early adipogenic factors. These findings identify a role for hedgehog signaling in white/brown adipocyte determination and link in vivo RNAi-based scanning of the Drosophila genome to regulation of adipocyte cell fate in mammals.
Location: No location found
No related grants have been discovered for Dominique FERRANDON.