ORCID Profile
0000-0003-0132-8182
Current Organisations
IT University of Copenhagen
,
Aarhus University
,
Univsersity of Aarhus
,
Copenhagen University Hospital Hvidovre
,
The Capital Region of Denmark
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Related Links
Publications
Weight affects survival of primary total knee arthroplasty: study based on the Danish Knee Arthroplasty Register with 67,810 patients and a median follow-up time of 5 years
Publisher: Medical Journals Sweden AB
Date: 05-12-2018
Author Correction: Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology.
Publisher: Springer Science and Business Media LLC
Date: 27-04-2022
A genome-wide meta-analysis identifies 53 sequence variants associating with carpal tunnel syndrome
Publisher: Research Square Platform LLC
Date: 14-01-2022
DOI: 10.21203/RS.3.RS-1189337/V1
Abstract: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy and has a largely unknown underlying biology. In a genome-wide association study of CTS ( N cases = 48,843, N controls = 1,190,837), we found 53 sequence variants at 50 loci that associate with the syndrome. The most significant association is with a missense variant (p.Glu366Lys) in SERPINA1 that protects against CTS ( P = 2.9 × 10 −24 , OR = 0.76). Through various functional analyses, we conclude that at least 22 genes mediate CTS risk and highlight the role of 19 CTS variants in the biology of the extracellular matrix. We show that the genetic component to the risk is higher in recurrent ersistent cases than nonrecurrent/nonresistant cases. Anthropometric traits including height and BMI are genetically correlated with CTS, in addition to early hormonal-replacement therapy, osteoarthritis, and restlessness. Our findings suggest that the components of the extracellular matrix play a key role in the pathogenesis of CTS.
Categorization of changes in the Oxford Knee Score after total knee replacement: an interpretive tool developed from a data set of 46,094 replacements
Publisher: Elsevier BV
Date: 04-2021
A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome
Publisher: Springer Science and Business Media LLC
Date: 24-03-2022
DOI: 10.1038/S41467-022-29133-7
Abstract: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy and has a largely unknown underlying biology. In a genome-wide association study of CTS (48,843 cases and 1,190,837 controls), we found 53 sequence variants at 50 loci associated with the syndrome. The most significant association is with a missense variant (p.Glu366Lys) in SERPINA1 that protects against CTS ( P = 2.9 × 10 −24 , OR = 0.76). Through various functional analyses, we conclude that at least 22 genes mediate CTS risk and highlight the role of 19 CTS variants in the biology of the extracellular matrix. We show that the genetic component to the risk is higher in bilateral/recurrent ersistent cases than nonrecurrent/nonpersistent cases. Anthropometric traits including height and BMI are genetically correlated with CTS, in addition to early hormonal-replacement therapy, osteoarthritis, and restlessness. Our findings suggest that the components of the extracellular matrix play a key role in the pathogenesis of CTS.
Knee replacement
Publisher: Elsevier BV
Date: 11-2018
Which Oxford Knee Score level represents a satisfactory symptom state after undergoing a total knee replacement?
Publisher: Medical Journals Sweden AB
Date: 13-10-2020
Persistent pain is common 1 year after ankle and wrist fracture surgery: a register-based questionnaire study
Publisher: Elsevier BV
Date: 05-2012
DOI: 10.1093/BJA/AEW069
Abstract: Substantial literature documents that persistent postsurgical pain is a possible outcome of many common surgical procedures. As fracture-related surgery implies a risk of developing neuropathic pain and complex regional pain syndrome (CRPS), further studies investigating the prevalence and pain characteristics are required. All patients undergoing primary surgery because of ankle or wrist fracture at Hvidovre and Odense University Hospitals, Denmark, between April 15, 2013 and April 15, 2014, were identified from the Danish Fracture Database. A questionnaire regarding pain characteristics was sent to patients 1 yr after primary surgery. Replies were received from 328 patients, of whom 18.9% experienced persistent postsurgical pain defined as pain daily or constantly at a level that interfered much or very much with daily activities, 42.8% reported symptoms suggestive of neuropathic pain, and 4.0% fulfilled the diagnostic patient-reported research criteria for CRPS. Persistent postsurgical pain 1 yr after wrist and ankle fracture surgery is frequent, and a large proportion of patients experience symptoms suggestive of neuropathic pain and CRPS. Patients should be informed about the substantial risk of developing persistent postsurgical pain. Future studies investigating risk factors for persistent postsurgical pain that include both surgically and conservatively treated fractures are required.
Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology
Publisher: Springer Science and Business Media LLC
Date: 02-02-2022
DOI: 10.1038/S41467-022-28167-1
Abstract: Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice dorsalgia (119,100 cases, 909,847 controls) and intervertebral disc disorder (IDD) (58,854 cases, 922,958 controls). We identify 41 variants at 33 loci. The most significant association (OR IDD = 0.92, P = 1.6 × 10 −39 OR dorsalgia = 0.92, P = 7.2 × 10 −15 ) is with a 3’UTR variant (rs1871452-T) in CHST3 , encoding a sulfotransferase enzyme expressed in intervertebral discs. The largest effects on IDD are conferred by rare (MAF = 0.07 − 0.32%) loss-of-function (LoF) variants in SLC13A1 , encoding a sodium-sulfate co-transporter (LoF burden OR = 1.44, P = 3.1 × 10 −11 ) variants that also associate with reduced serum sulfate. Genes implicated by this study are involved in cartilage and bone biology, as well as neurological and inflammatory processes.
The next critical role of orthopedic registries
Publisher: Medical Journals Sweden AB
Date: 02-01-2015
Related Organisations
Related Funding Activities
No related grants have been discovered for Anders Troelsen.