ORCID Profile
0000-0001-6462-3504
Current Organisation
Federal University of São João del-Rei
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Springer Science and Business Media LLC
Date: 19-12-2020
DOI: 10.1007/S00296-019-04496-1
Abstract: Information on measurement properties of translated versions of the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index is still limited. This study investigated the internal consistency, test-retest reliability/agreement, construct validity, and floor and ceiling effects of Portuguese-Brazil WOMAC applied to civil servants at baseline of ELSA-Brasil Musculoskeletal cohort. Each measurement property was evaluated in the overall s le, in the subgroup reporting knee symptoms, and across different sociodemographic strata (except factorial analyses). Separate analyses were performed for pain, stiffness and function dimensions, considering the knee with the worst score (or right knee if same score in both knees). A total of 1740 participants were included (319 completed WOMAC on 2 occasions), mean age 56.0 (standard deviation = 8.9) years, 46.8% male, 42.1% had knee symptoms. In the overall s le, the range of results for WOMAC's dimensions were: internal consistency = cronbach alpha 0.92-0.98 test-retest reliability = intraclass correlation coefficient 0.85-0.97 standard error of measurement (SEM) = 1.38-5.86 smallest detectable change (SDC) = 3.84-16.25 lowest possible score = 38.8%-61.1% (floor effect present) highest possible score = 0.2%-0.9% (ceiling effect absent). Construct validity was confirmed by hypothesis testing and factorial analysis. Results were similar in the symptomatic group, except for higher SEM and SDC, and the absence of floor effects in pain and function dimensions. Portuguese-Brazil WOMAC showed good overall quality in a nonclinical setting. Variability in measurement properties across different strata of the population should be taken into consideration for the design of future studies using WOMAC.
Publisher: Editora Blucher
Date: 08-2019
DOI: 10.5151/SBR2019-587
Publisher: American Psychiatric Association Publishing
Date: 12-2014
DOI: 10.1176/APPI.AJP.2014.13121605
Abstract: Increases in resting-state heart rate and decreases in its variability are associated with substantial morbidity and mortality, yet contradictory findings have been reported for the effects of the mood and anxiety disorders and of antidepressants. The authors investigated heart rate and heart rate variability in a large cohort from Brazil, using propensity score weighting, a relatively novel method, to control for numerous potential confounders. A total of 15,105 participants were recruited in the Brazilian Longitudinal Study of Adult Health. Mood and anxiety disorders were ascertained using the Portuguese version of the Clinical Interview Schedule-Revised. Heart rate and its variability were extracted from 10-minute resting-state electrocardiograms. Regressions weighted by propensity scores were carried out to compare participants with and without depressive or anxiety disorders, as well as users and non-users of antidepressants, on heart rate and heart rate variability. Use of antidepressants was associated with increases in heart rate and decreases in its variability. Effects were most pronounced for the tricyclic antidepressants (Cohen's d, 0.72-0.81), followed by serotonin and norepinephrine reuptake inhibitors (Cohen's d, 0.42-0.95) and other antidepressants (Cohen's d, 0.37-0.40), relative to participants not on antidepressants. Only participants with generalized anxiety disorder showed robust, though small, increases in heart rate and decreases in its variability after propensity score weighting. The findings may, in part, underpin epidemiological findings of increased risk for cardiovascular morbidity and mortality. Many factors that have an adverse impact on cardiac activity were controlled for in this study, highlighting the importance of cardiovascular risk reduction strategies. Further study is needed to examine whether, how, and when such effects contribute to morbidity and mortality.
Publisher: Springer Science and Business Media LLC
Date: 06-2023
Publisher: Research Square Platform LLC
Date: 16-02-2023
DOI: 10.21203/RS.3.RS-2570466/V1
Abstract: Purpose. To investigate the association between statins and muscle problems in a highly erse s le of Brazilian civil servants. Methods. We conducted a cross-sectional data analysis at baseline of the ELSA-Brasil MSK cohort. Pain was identified through self-reported symptoms in large muscle groups (lower back and/or hips/thighs). Muscle strength was assessed using the five-times-sit-to-stand (FTSTS) and handgrip tests, with weakness defined as the lowest and highest quintiles of age− and sex−stratified handgrip strength and FTSTS performance time, respectively. Multivariable logistic regression analyses were conducted to investigate the association between statin use and muscle pain and weakness. Secondary analyses explored the impact of different types of statins and their duration of use on the response variables. Results. A total of 2,156 participants (mean age 55.6 ± SD 8.9, 52.8% women) were included. We found no significant association between statin use and muscle problems. Secondary exploratory analysis on different types of statins revealed an association between atorvastatin and muscle weakness, as measured by the five-times-sit-to-stand test (OR 1.94 IC 95% 1.12–3.37), but not by the handgrip test (OR 0.75 IC 95% 0.29–1.42). No evidence was found to support a link between the duration of statin treatment and muscle problems. Conclusions. This study challenges previous claims of an efficacy-effectiveness gap between experimental and observational literature on statins, offering important insights into the widespread prescription of statins in erse populations. The findings indicate that statin use does not contribute to muscular problems.
Location: Brazil
No related grants have been discovered for Roberta Carvalho de Figueiredo.