ORCID Profile
0000-0002-0565-3161
Current Organisations
IT University of Copenhagen
,
University of Toronto
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Publisher: Elsevier BV
Date: 09-2009
DOI: 10.1016/J.JOEN.2009.05.005
Abstract: M-Wire (Sportswire LLC, Langley, OK) is reportedly created by altering alloy temperatures during the manufacturing process of GT series X instruments (Dentsply Tulsa Dental Specialties, Tulsa, OK). Currently, there are few published studies looking at torsional profiles of these instruments. The purpose of this study was to investigate the torsional profiles of new and used 20/0.06 GT series X (GTX) and GT (GT) instruments (Dentsply Tulsa Dental Specialties). Thirty instruments were allocated to one of eight groups and were used 2, 6, or 10 times in simulated canals or remained as unused controls. Testing of torque (TF) and angle at fracture (AF) were conducted in accordance with American National Standards Institute/American Dental Association (ANSI/ADA) specification No. 28. Data analyses were performed by using one- and two- way analysis of variance with honesty significance difference post hoc comparison with alpha = 0.05. Overall, there were significant differences in TF and AF among the experimental groups (p < 0.001). GTX instruments showed a significant initial increase in TF with two and six uses (p < 0.001) in contrast to the GT, which showed a linear reduction in TF with increased use (p < 0.004). Both GTX and GT instruments showed no statistical difference in AF of new instruments but did show a significant decrease in AF in all groups except the GT two-use group (p < 0.02). The GTX instruments had a higher resistance to torsional failure after use as compared with the GT.
Publisher: SAGE Publications
Date: 26-08-2015
DOI: 10.1111/IJS.12611
Abstract: In developing countries, there are few comprehensive studies of mortality following stroke. We aimed to determine the one-year case fatality rate following stroke and to identify factors associated with death in a population-based stroke incidence study in Iran. Six hundred eighty-four patients who had suffered a stroke between November 21, 2006, and November 20, 2007, and were recruited to the Mashhad Stroke Incidence Study were followed up at one-year. Most patients were seen in an outpatient visit. When patients had died, a verbal autopsy was conducted by telephone with the next of kin. A total of 226 (34.3%) patients died during the first year following stroke. The cumulative one-year case fatality rate was 30.6% following ischemic stroke and 53.0% following hemorrhagic stroke (55.8% after intracerebral hemorrhage and 35.7% after subarachnoid hemorrhage). The majority of these deaths occurred in the first 28 days after stroke (17.7% with ischemic and 43.0% with hemorrhagic stroke). Factors associated with greater mortality at one-year (excluding those who died during the first week) were hemorrhagic stroke [hazard ratio (HR) 3.99 95% confidence interval 1.90-8.37], age (HR 1.05 95% confidence interval 1.03-1.08), previous transient ischemic attack (HR 2.45 95% confidence interval 1.00-5.99), and National Institutes of Health Stroke Scale on admission (HR 1.14 95% confidence interval 1.10-1.17). Despite the younger age of stroke occurrence in Iran, the one-year case fatality rate following stroke is similar to that reported in developed countries.
Publisher: Oxford University Press (OUP)
Date: 04-10-2021
DOI: 10.1093/NAR/GKAB859
Abstract: Many prokaryotes encode CRISPR-Cas systems as immune protection against mobile genetic elements (MGEs), yet a number of MGEs also harbor CRISPR-Cas components. With a few exceptions, CRISPR-Cas loci encoded on MGEs are uncharted and a comprehensive analysis of their distribution, prevalence, ersity, and function is lacking. Here, we systematically investigated CRISPR-Cas loci across the largest curated collection of natural bacterial and archaeal plasmids. CRISPR-Cas loci are widely but heterogeneously distributed across plasmids and, in comparison to host chromosomes, their mean prevalence per Mbp is higher and their distribution is distinct. Furthermore, the spacer content of plasmid CRISPRs exhibits a strong targeting bias towards other plasmids, while chromosomal arrays are enriched with virus-targeting spacers. These contrasting targeting preferences highlight the genetic independence of plasmids and suggest a major role for mediating plasmid-plasmid conflicts. Altogether, CRISPR-Cas are frequent accessory components of many plasmids, which is an overlooked phenomenon that possibly facilitates their dissemination across microbiomes.
Publisher: Springer Science and Business Media LLC
Date: 12-2013
Publisher: Cold Spring Harbor Laboratory
Date: 04-06-2021
DOI: 10.1101/2021.06.04.447074
Abstract: Many prokaryotes encode CRISPR-Cas systems as immune protection against mobile genetic elements (MGEs), yet, a number of MGEs also harbor CRISPR-Cas components. With a few exceptions, CRISPR-Cas loci encoded on MGEs are uncharted and a comprehensive analysis of their distribution, prevalence, ersity, and function is lacking. Here, we systematically investigated CRISPR-Cas loci across the largest curated collection of natural bacterial and archaeal plasmids. CRISPR-Cas loci are widely but heterogeneously distributed across plasmids and, in comparison to host chromosomes, their mean prevalence per Mbp is higher and their distribution is markedly distinct. Furthermore, the spacer content of plasmid CRISPRs exhibits a strong targeting bias towards other plasmids, while chromosomal arrays are enriched with virus-targeting spacers. These contrasting targeting preferences dominate across the ersity of CRISPR-Cas subtypes and host taxa, highlighting the genetic independence of plasmids and suggesting a major role of CRISPR-Cas for mediating plasmid-plasmid conflicts. Altogether, CRISPR-Cas are frequent accessory components of many plasmids, which is an overlooked phenomenon that possibly facilitates their dissemination across microbiomes.
Publisher: Cold Spring Harbor Laboratory
Date: 28-08-2023
DOI: 10.1101/2023.08.28.555054
Abstract: Motivation Metagenomic sequencing has provided great advantages in the characterization of microbiomes, but currently available analysis tools lack the ability to combine strain-level taxonomic resolution and abundance estimation with functional profiling of assembled genomes. In order to define the microbiome and its associations with human health, improved tools are needed to enable comprehensive understanding of the microbial composition and elucidation of the phylogenetic and functional relationships between the microbes. Results Here, we present MAGinator, a freely available tool, tailored for the profiling of shotgun metagenomics datasets. MAGinator provides de novo identification of subspecies-level microbes and accurate abundance estimates of metagenome-assembled genomes (MAGs). MAGinator utilises the information from both gene- and contig-based methods yielding insight into both taxonomic profiles and the origin of genes as well as genetic content, used for inference of functional content of each s le by host organism. Additionally, MAGinator facilitates the reconstruction of phylogenetic relationships between the MAGs, providing a framework to identify clade-level differences within subspecies MAGs. Availability and implementation: MAGinator is available as a Python module at: github.com/Russel88/MAGinator
No related grants have been discovered for Jakob Russel.