ORCID Profile
0000-0003-3898-6955
Current Organisation
Università degli Studi di Milano
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Publisher: Wiley
Date: 12-10-2022
DOI: 10.1002/VETR.2282
Abstract: In humans, blood groups are associated with varying prevalence of infections. The aim of this study was to determine if associations exist between the feline AB blood group system and haemoplasma infection. Data from two studies were combined. In the first study, DNA s les from 131 haemoplasma‐infected and 132 haemoplasma‐uninfected UK cats underwent pyrosequencing to determine their blood genotype as AA , Ab or bb . In the second study, blood s les from 160 Italian cats of known blood phenotype A, B or AB underwent PCR testing for feline haemoplasma species DNA. Haemoplasma infection was demonstrated in cats of all phenotypes and genotypes. A significantly higher number of Ab genotype cats tested positive for overall haemoplasma infection status ( p = 0.04) and for Mycoplasma haemofelis infection ( p = 0.03). Haemoplasma‐infected Italian cats were few, possibly increasing the chance of type II error, and the presence of purebred cats in the s le population may have had a confounding effect. Feline haemoplasmas do not appear to preferentially use either blood type A or B antigens as attachment sites for erythrocyte colonisation. Further investigations in a larger number of haemoplasma‐infected cats of known blood phenotype are warranted to explain the association between genotype Ab and haemoplasma infection.
Publisher: Wiley
Date: 03-2021
DOI: 10.1111/VEC.13045
Abstract: To systematically review available evidence to develop guidelines for the prevention of transfusion reactions and monitoring of transfusion administration in dogs and cats. Evidence evaluation of the literature (identified through Medline searches through Pubmed and Google Scholar searches) was carried out for identified transfusion reaction types in dogs and cats. Evidence was evaluated using PICO (Population, Intervention, Comparison, Outcome) questions generated for each reaction type. Evidence was categorized by level of evidence (LOE) and quality (Good, Fair, or Poor). Guidelines for prevention and monitoring were generated based on the synthesis of the evidence. Consensus on the final recommendations and a proposed transfusion administration monitoring form was achieved through Delphi‐style surveys. Draft recommendations and the monitoring form were made available through veterinary specialty listservs and comments were incorporated. Twenty‐nine guidelines and a transfusion administration monitoring form were formulated from the evidence review with a high degree of consensus This systematic evidence evaluation process yielded recommended prevention and monitoring guidelines and a proposed transfusion administration form. However, significant knowledge gaps were identified, demonstrating the need for additional research in veterinary transfusion medicine.
Publisher: Wiley
Date: 03-2021
DOI: 10.1111/VEC.13044
Abstract: To use a systematic, evidence‐based consensus process to develop definitions for transfusion reactions in dogs and cats. Evidence evaluation of the literature was carried out for identified transfusion reaction types in dogs and cats. Reaction definitions were generated based on synthesis of human and veterinary literature. Consensus on the definitions was achieved through Delphi‐style surveys. Draft recommendations were made available through industry specialty listservs and comments were incorporated. Definitions with imputability criteria were developed for 14 types of transfusion reactions. The evidence review and consensus process resulted in definitions that can be used to facilitate future veterinary transfusion reaction research.
Publisher: SAGE Publications
Date: 30-05-2022
DOI: 10.1177/1098612X221100082
Abstract: The relationship between blood group antigens and disease has been studied in humans. Blood types have been associated with both decreased and increased rates of various infections. In addition, blood group expression has been shown to vary with some cancers and gastrointestinal diseases. The objective of this study was to explore whether there is a relationship between blood type and retroviral infections in cats. Case records from a veterinary research laboratory, veterinary teaching hospitals and veterinary blood banks were retrospectively searched for cats where both blood type and retroviral status (feline leukemia [FeLV], feline immunodeficiency virus [FIV] or both) were listed (part 1). In addition, a s le of 33 cats with confirmed FIV infection was genotyped to determine blood groups (part 2). In part 1, 709 cats were identified, 119 of which were positive for retroviral infection. Among all cases, 621 were type A (87.6%), 68 were type B (9.6%) and 20 were type AB (2.8%). There was no relationship between overall retroviral status (positive/negative) and blood type ( P = 0.43), between FeLV status and blood type ( P = 0.86) or between FIV status and blood type ( P = 0.94). There was no difference in the distribution of blood types between cats that were healthy and typed as possible blood donors vs sick cats that were typed prior to a possible transfusion ( P = 0.13). In part 2, of the 33 FIV-infected cats, all blood group genotypes were identified, although this test did not discriminate type A from type AB. No relationship was identified between feline retroviral status and blood type in this study. The relationship between blood type and other disease states requires further study in veterinary patients.
Publisher: Wiley
Date: 03-2021
DOI: 10.1111/VEC.13043
Abstract: To systematically review available evidence to develop guidelines for diagnosis and treatment of transfusion‐associated reactions in dogs and cats. Standardized and systemic evaluation of the literature (identified through Medline via PubMed and Google Scholar searches) was carried out for identified transfusion reaction types in dogs and cats. The available evidence was evaluated using PICO (Population, Intervention, Comparison, Outcome) questions generated for each reaction type. The evidence was categorized by level of evidence (LOE) and quality (Good, Fair, or Poor). Guidelines, diagnostic, and treatment algorithms were generated based on the evaluation of the evidence. Consensus on the final guidelines was achieved through Delphi‐style surveys. Draft recommendations were disseminated through veterinary specialty listservs for review and comments, which were evaluated and integrated prior to final publication. Medline via PubMed and Google Scholar databases were searched. There were 14 Population Intervention Comparison Outcome questions identified and corresponding worksheets were developed focusing on the diagnosis and treatment of transfusion‐associated reactions in dogs and cats. Fourteen guidelines and four algorithms were developed with a high degree of consensus. This systematic evidence evaluation process yielded recommended diagnostic and treatment algorithms for use in practice. However, significant knowledge gaps were identified, demonstrating the need for additional research in veterinary transfusion medicine.
No related grants have been discovered for EVA SPADA.