Publication
The chromatin accessibility landscape of primary human cancers
Publisher:
American Association for the Advancement of Science (AAAS)
Date:
26-10-2018
DOI:
10.1126/SCIENCE.AAV1898
Abstract: The Cancer Genome Atlas (TCGA) provides a high-quality resource of molecular data on a large variety of human cancers. Corces et al. used a recently modified assay to profile chromatin accessibility to determine the accessible chromatin landscape in 410 TCGA s les from 23 cancer types (see the Perspective by Taipale). When the data were integrated with other omics data available for the same tumor s les, inherited risk loci for cancer predisposition were revealed, transcription factors and enhancers driving molecular subtypes of cancer with patient survival differences were identified, and noncoding mutations associated with clinical prognosis were discovered. Science , this issue p. eaav1898 see also p. 401