ORCID Profile
0000-0003-1636-7766
Current Organisations
Tufts University
,
Universite de Geneve
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Publisher: Wiley
Date: 09-06-2022
Publisher: Wiley
Date: 20-05-2022
Abstract: A Ru(bpy) 3 Cl 2 photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene‐containing pharmacological agents, including combretastatin A‐4 (CA‐4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to potent cytotoxic agents. Selective in cellulo activation of the CA‐4 analog Res‐3M is demonstrated, along with its potent cytotoxicity and inhibition of microtubule dynamics.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7SC02736B
Abstract: A PNA-templated peptide ligation reaction has been developed between selenocystine and selenoesters. The methodology was used for the sequence specific detection of miRNA at low concentrations.
Publisher: Elsevier BV
Date: 02-2022
DOI: 10.1016/J.CBPA.2021.102104
Abstract: Nature is predicated on the ability to process large number of parallel signals to produce specific downstream outputs. Biosupramolecular networks are beginning to allow such processing power in synthetic systems, particularly through harnessing the recognition power of biomolecules. Such systems can be summarised through the reductionist view of containing inputs, circuitry motifs and functional outputs, with each of these elements able to be readily combined in a modular approach. Through the inherent 'plug and play' nature of these systems the field continues to rapidly expand, providing a wealth of new smart diagnostic and therapeutic systems.
Publisher: MDPI AG
Date: 20-10-2022
DOI: 10.3390/BIOM12101523
Abstract: Nucleic acids and proteins form two of the key classes of functional biomolecules. Through the ability to access specific protein-oligonucleotide conjugates, a broader range of functional molecules becomes accessible which leverages both the programmability and recognition potential of nucleic acids and the structural, chemical and functional ersity of proteins. Herein, we summarize the available conjugation strategies to access such chimeric molecules and highlight some key case study ex les within the field to showcase the power and utility of such technology.
Publisher: Wiley
Date: 05-11-2021
Abstract: Biomedical research has been empowered by tools that enable spatial and temporal control of biological systems. These have predominantly come from photocaged bioactive molecules (optochemical control N. Ankenbruck, T. Courtney, Y. Naro, A. Deiters, Angew. Chem. Int. Ed . 2018 , 57 , 2768–2798) and light‐dependent proteins (optogenetic control L. Fenno, O. Yizhar, K. Deisseroth, Annu. Rev. Neurosci . 2011 , 34 , 389–412). Recent advances in photocatalysis offer the opportunity to lify these strategies by providing new dimension of biorthogonality. Photocatalysis also empowers bioconjugation with unprecedented reactivities enabling new crosslinking chemistry or biomolecule functionalization, while merging photocatalysis with biocatalysis extends the scope of both of these powerful classes of transformation.
Publisher: Wiley
Date: 20-05-2022
Abstract: A Ru(bpy) 3 Cl 2 photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene‐containing pharmacological agents, including combretastatin A‐4 (CA‐4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to potent cytotoxic agents. Selective in cellulo activation of the CA‐4 analog Res‐3M is demonstrated, along with its potent cytotoxicity and inhibition of microtubule dynamics.
Publisher: Wiley
Date: 09-06-2022
Publisher: Wiley
Date: 24-10-2023
No related grants have been discovered for Nicolas Winssinger.