ORCID Profile
0000-0002-6696-0923
Current Organisation
University of Warwick Warwick Medical School
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Oxford University Press (OUP)
Date: 22-10-2008
DOI: 10.1093/AJE/KWN337
Publisher: Oxford University Press (OUP)
Date: 15-11-2007
DOI: 10.1093/AJE/KWM302
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 10-2010
DOI: 10.1161/ATVBAHA.110.206987
Abstract: Objective— To examine the relationship between sleep duration and hemostatic factors in a well-characterized cohort. Methods and Results— The relationship between self-reported sleep duration and von Willebrand factor (vWF), fibrinogen, and factor VII was examined in approximately 6400 in iduals from the Whitehall II Study. The analysis was stratified by sex (interaction P .001). After multiple adjustments, vWF levels were significantly higher in men with both short sleep duration (≤6 hours per night 1.05 [95% CI, 1.01 to 1.08] [data given as geometric mean]) and long sleep duration (≥8 hours per night 1.05 [95% CI, 1.02 to 1.08]) compared with those who slept 7 hours ( P .05 for both). In women, levels of vWF were significantly higher in in iduals who slept 8 hours or longer (1.11 [95% CI, 1.06 to 1.16]) compared with 7 hours ( P .05). This difference was observed in premenopausal and postmenopausal women. In women, the association was nonlinear ( P =0.02), but not in men ( P =0.09). No statistically significant associations between sleep duration and fibrinogen or factor VII were observed. Conclusion— Men who slept for short and long durations had higher vWF levels. In women, there was a significant nonlinear association. The highest levels were observed in long sleepers, irrespective of menopausal status. No major associations between sleep and factor VII or fibrinogen were observed. Longitudinal studies are required to investigate causality.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 10-2007
DOI: 10.1161/HYPERTENSIONAHA.107.095471
Abstract: Sleep deprivation (≤5 hour per night) was associated with a higher risk of hypertension in middle-aged American adults but not among older in iduals. However, the outcome was based on self-reported diagnosis of incident hypertension, and no gender-specific analyses were included. We examined cross-sectional and prospective associations of sleep duration with prevalent and incident hypertension in a cohort of 10 308 British civil servants aged 35 to 55 years at baseline (phase 1: 1985–1988). Data were gathered from phase 5 (1997–1999) and phase 7 (2003–2004). Sleep duration and other covariates were assessed at phase 5. At both examinations, hypertension was defined as blood pressure ≥140/90 mm Hg or regular use of antihypertensive medications. In cross-sectional analyses at phase 5 (n=5766), short duration of sleep (≤5 hour per night) was associated with higher risk of hypertension compared with the group sleeping 7 hours, among women (odds ratio: 2.01 95% CI: 1.13 to 3.58), independent of confounders, with an inverse linear trend across decreasing hours of sleep ( P =0.003). No association was detected in men. In prospective analyses (mean follow-up: 5 years), the cumulative incidence of hypertension was 20.0% (n=740) among 3691 normotensive in iduals at phase 5. In women, short duration of sleep was associated with a higher risk of hypertension in a reduced model (age and employment) (6 hours per night: odds ratio: 1.56 [95% CI: 1.07 to 2.27] ≤5 hour per night: odds ratio: 1.94 [95% CI: 1.08 to 3.50] versus 7 hours). The associations were attenuated after accounting for cardiovascular risk factors and psychiatric comorbidities (odds ratio: 1.42 [95% CI: 0.94 to 2.16] odds ratio: 1.31 [95% CI: 0.65 to 2.63], respectively). Sleep deprivation may produce detrimental cardiovascular effects among women.
Publisher: Elsevier BV
Date: 06-2009
DOI: 10.1016/J.ATHEROSCLEROSIS.2008.09.019
Abstract: To examine the impact of -174G>C and -572G>C variants in the promoter region of the IL6 gene, and their interactions with social position, on interleukin-6 (IL-6) levels in the Whitehall II cohort. SNPs were genotyped by TaqMan. IL-6 was measured by ELISA. Employment grade was assessed to indicate social position. ANOVAs were used to examine genotype-phenotype associations. 4165 white men and women provided data on IL-6 levels at two study time points, Phase 3 (1991-1993) and Phase 7 (2002-2004). Distributions were as expected for Hardy-Weinberg equilibrium. At Phase 3, overall IL-6 levels did not differ by either genotype, but -174C was associated with higher IL-6 levels within the lowest employment grades (p(interaction)=0.046). At Phase 7, IL-6 levels overall were 6% higher in -174C (p=0.002) and 9% lower in -572C (p=0.003) carriers. The lowering effect of -572C was not apparent in the lowest employment grades (p(interaction)=0.05). IL-6 levels are determined in part by interaction between common functional IL6 gene variants and yet to be identified components of social position. These results highlight the importance of considering interactions between genes and social environments in future study designs.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Michelle A Miller.