ORCID Profile
0000-0001-7898-903X
Current Organisation
National University of Ireland Maynooth
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Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6SC01011C
Abstract: Macrocyclic squaramide derivatives bind sulfate ions with high selectivity and affinity in aqueous mixtures.
Publisher: Informa UK Limited
Date: 17-11-2015
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7OB01406F
Abstract: Two 2-nitroimidazole-1,8-naphthalimide conjugates, 1 and 2 , have been synthesised as fluorescence probes for the detection of reductive stress in HeLa cells.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5CC03625A
Abstract: An oxothiosquaramide was shown to bind to chloride through hydrogen bonding interactions in DMSO and found to exhibit pH switchable chloride transport across phospholipid bilayers via an antiport transport mechanism.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SM01075H
Abstract: First ex le of glycosyl squaramides that induce the efficient gelation of high polarity solvents and hydroethanolic mixtures.
Publisher: American Chemical Society (ACS)
Date: 20-09-2011
DOI: 10.1021/JA2061159
Abstract: The synthesis and photophysical and biological investigation of Ru(II)-polypyridyl stabilized water-soluble, luminescent gold nanoparticles (AuNPs) are described. These structures bind to DNA and undergo rapid cellular uptake, being localized within the cell cytoplasm and nucleus within 4 h.
Publisher: Frontiers Media SA
Date: 09-12-2020
Publisher: Elsevier BV
Date: 06-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9RA04908H
Abstract: With this research we set out to develop of a number of coumarin-based ‘AND’ logic fluorescence probes that were capable of detecting a chosen analyte in the presence of HCys.
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4SC01629G
Abstract: Thiosquaramides show pH controlled anion transport properties in lipid bilayers.
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2CC17274G
Abstract: The synthesis and photophysical properties of 1 and 2, two Ru(II)-polypyridyl based-1,8-naphthalimide Tröger's bases, are described these were found to stabilize double stranded DNA, undergo rapid cellular uptake, displaying good luminescence without affecting cell viability even after 24 hours of incubation.
Publisher: BMJ
Date: 23-06-2016
Publisher: MDPI AG
Date: 29-11-2021
DOI: 10.3390/PHARMACEUTICS13122032
Abstract: The importance of zinc in biology has gained greater recognition in recent years due to its essential contributions to the function of many endogenous enzymes. Disruption of zinc homeostasis may be useful in treating pathological conditions, such as Alzheimer’s, and for antiviral purposes. Despite the growth of knowledge and increased interest in zinc, little is known about the structure and function of zinc ionophores. In this study we analyse the Cambridge Structural Database and solution complexation studies found in the literature to identify key functional groups which may confer zinc ionophorism. Pharmaceuticals, nutraceuticals and amino acids with these functionalities were selected to enable us to explore the translatability of ionophoric activity from in vitro assays to cellular systems. We find that although certain species may complex to zinc in the solid and solution states, and may carry ions across simple membrane systems, this does not necessarily translate into ionophoric activity. We propose that the CSD can help refine key functionalities but that ionophoric activity must be confirmed in cellular systems.
Publisher: American Chemical Society (ACS)
Date: 16-07-2020
Publisher: Informa UK Limited
Date: 07-03-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CC04316G
Abstract: A novel fluorescence-based scaffold was developed enabling the production of ‘AND’ based fluorescence probes – ROS/RNS and a second analyte.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C4CC10095F
Abstract: Cyclic peptides provide excellent scaffolds for anion recognition and improved binding affinity and selectivity has been achieved through peptide backbone rigidification and the introduction of side chains bearing anion recognition groups.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9SC02197C
Abstract: The tumour switches on the NIR-AZA emission for fluorescence guided surgery.
Publisher: Springer Science and Business Media LLC
Date: 23-09-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9SC04786G
Abstract: Lipophilic macrocycles efficiently extract sulfate ions from water into chloroform and transport this ion across a bulk liquid membrane in the presence of competing anions (chloride, nitrate and dihydrogenphosphate).
Publisher: Wiley
Date: 14-05-2014
Abstract: The synthesis of six small peptide anion receptors based on thiourea and squaramide recognition moieties is described. These new receptors bind to tetrahedral sulfate anions with remarkable affinity and selectivity in aqueous solution as shown by NMR spectroscopy. Molecular modelling suggests that selectivity is mediated by a hydrogen bond network incorporating the amide backbone protons in a manner similar to that found in the sulfate-binding protein.
Publisher: Elsevier BV
Date: 02-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6CC01037G
Abstract: The development of new optical chemosensors for various reductases presents an ideal approach to visualise areas of tissue hypoxia.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CC06812K
Abstract: Water soluble macrocyclic squaramides bind selectively to sulfate in aqueous–DMSO mixtures across a pH range from 3.2–14.
Publisher: Elsevier BV
Date: 2019
Publisher: Elsevier BV
Date: 06-2021
Publisher: CSIRO Publishing
Date: 2017
DOI: 10.1071/CH16567
Abstract: A series of side-chain modified peptides have been prepared via an iterative sequence of peptide couplings and azide–alkyne cycloadditions (‘click’ reactions) using Fmoc-solid phase peptide synthesis. This efficient modular synthetic route allows the systematic and sequential incorporation of a variety of side-chain modifications onto short peptides. The versatility of this approach was demonstrated by the synthesis of a series of short peptides with appended anion recognition motifs and fluorescent indicators.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5NR05598A
Abstract: The development of 15 nm (average size) Ru( ii ) functionalized gold nanoparticles 1–3·AuNP is described.
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2DT00020B
Abstract: The new Ru(II) polypyridyl complex 1 was synthesised using microwave irradiation from the new polypyridyl ligand 2'DipyTAP', and its photophysical properties, and DNA binding abilities were investigated using various spectroscopic techniques and 1 was shown to act as a 'NIR molecular light switch' for DNA with an emission window between 680 and 860 nm.
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2OB01176J
Abstract: We report a family of amidosquaramides with pKa values close to physiological pH. Intramolecular H-bonding affects anion binding leading to moderate Cl − transmembrane transport at physiological pH, but under acidic conditions anion transport is effectively ‘switched on’.
Publisher: Springer Science and Business Media LLC
Date: 17-01-2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C0CC04303F
Abstract: The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.
Publisher: Wiley
Date: 08-2021
Abstract: The synthesis and characterisation of two novel self‐assembled hiphiles (SSAs) SQS‐1 and SQS‐2 are reported. Both compounds, based on the squaramide motif, were fully soluble in a range of solvents and were shown to undergo self‐assembly through a range of physical techniques. Self‐assembly was shown to favour the formation of crystalline domains on the nanoscale but also fibrillar film formation, as suggested by SEM analysis. Moreover, both SQS‐1 and SQS‐2 were capable of anion recognition in DMSO solution as demonstrated using 1 H NMR and UV/Vis absorption spectroscopy, but displayed lower binding affinities for various anions when compared against other squaramide based receptors. In more competitive solvent mixtures SQS‐1 gave rise to a colourimetric response in the presence of HPO 4 2− that was clearly visible to the naked eye. We anticipate that the observed response is due to the basic nature of the HPO 4 2− anion when compared against other biologically relevant anions.
Publisher: Informa UK Limited
Date: 18-04-2018
Publisher: Elsevier BV
Date: 02-2021
Publisher: American Chemical Society (ACS)
Date: 29-10-2013
DOI: 10.1021/OL402500Q
Abstract: The synthesis and photophysical properties of four squaramide based fluorescent anion sensors (1-4) are described. These luminescent compounds showed selectivity for Cl(-) over various other anions with concomitant changes in both their UV/visible and fluorescence properties upon Cl(-) addition, attributed to initial H-bonding followed by NH deprotonation in the presence of excess Cl(-), signaled by a color change. The nature of the electron withdrawing aryl substituents is directly related to the H-bonding ability/acidity of the squaramide protons and can be used to tune the deprotonation behavior.
Publisher: Elsevier BV
Date: 08-2010
Publisher: Frontiers Media SA
Date: 22-05-2019
Publisher: Elsevier BV
Date: 09-2023
Publisher: Informa UK Limited
Date: 16-01-2012
No related grants have been discovered for Robert Elmes.