ORCID Profile
0000-0001-5542-5581
Current Organisation
Northern Arizona University
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Publisher: American Physiological Society
Date: 03-2021
DOI: 10.1152/AJPREGU.00263.2020
Abstract: The modified C bell diagram provides one of the most comprehensive assessments of the work of breathing (Wb) during exercise, wherein the resistive and elastic work of inspiration and expiration are quantified. Importantly, a necessary step in constructing the modified C bell diagram is to obtain a value for chest wall compliance (C CW ). To date, it remains unknown whether estimating or directly measuring C CW impacts the Wb, as determined by the modified C bell diagram. Therefore, the purpose of this study was to evaluate whether the components of the Wb differ when the modified C bell diagram is constructed using an estimated versus measured value of C CW . Forty-two participants ( n = 26 men, 16 women) performed graded exercise to volitional exhaustion on a cycle ergometer. C CW was measured directly at rest via quasistatic relaxation. Estimated values of C CW were taken from prior literature. The measured value of C CW was greater than that obtained via estimation (214 ± 52 mL/cmH 2 O vs. 189 ± 18 mL/cmH 2 O P 0.05). At modest-to-high minute ventilations (i.e., 50–200 L/min), the inspiratory elastic Wb was greater and expiratory resistive Wb was lower, when modified C bell diagrams were constructed using estimated compared with measured values of C CW ( P = 0.001). These differences were however small and never exceeded ±5%. Thus, although our findings demonstrate that estimating C CW has a measurable impact on the determination of the Wb, its effect appears relatively small within a cohort of healthy adults during graded exercise.
Publisher: American Physiological Society
Date: 09-2021
DOI: 10.1152/JAPPLPHYSIOL.00411.2021
Abstract: The measurement of the work of breathing (Wb) during exercise provides us with deep insights into respiratory (patho)physiology, and sheds light on the putative factors which lead to respiratory muscle fatigue. There are 4 popular methods available to determine the Wb. Our study demonstrates that no two of these methods produce identical values of Wb during exercise. This paper also discusses the practical and theoretical limitations of each method.
Publisher: Wiley
Date: 03-2020
DOI: 10.14814/PHY2.14404
Location: United States of America
No related grants have been discovered for Joseph Duke.