ORCID Profile
0000-0002-5440-9317
Current Organisations
Australian National University
,
Federal University of Paraíba
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Publisher: Wiley
Date: 19-02-2020
Publisher: FapUNIFESP (SciELO)
Date: 12-2020
DOI: 10.1590/1517-869220202606222490
Abstract: ABSTRACT Introduction: Strength training with blood flow restriction (BFR) involves the use of low loads (20-30% of 1RM) with restriction of blood flow to promote gains in physical fitness. The restriction can be applied continuously or intermittently however, it is unclear how it affects the hemodynamics of hypertensive women. Objective: To analyze the acute effect of resistance exercise (RE) on the upper and lower limbs with continuous and intermittent blood flow restriction (BFR) on the hemodynamic variables of women with hypertension. Methods: Thirteen women with controlled hypertension (40 to 65 years) underwent eight experimental protocols, with a randomized, counter balanced, crossover design four exercise sessions for the right upper limb (elbow flexion) and four for the right lower limb (knee extension). The systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and heart rate (HR) were measured before, during, immediately after and 15, 30, 45 and 60 minutes after the exercises. Results: There were no significant interactions between the protocols vs. segments vs. time, protocols vs. segments, protocols vs. time, segments vs. time, protocol, segment and time, on the variables SAP, DAP, and HR during and after the RE (p .05). Although all these protocols had significantly elevated SAP, DAP and HR, the values remained within the normal range. The protocols of this study did not cause hypotensive effect. Conclusion: Low-load RE combined with continuous and intermittent BFR, on the upper and lower limbs, appears to promote similar variations in the hemodynamic variables of women with hypertension. Level of evidence II Randomized clinical trial.
Publisher: American Chemical Society (ACS)
Date: 10-05-2022
DOI: 10.1021/ACS.CHEMREV.1C00990
Abstract: Optical metasurfaces are planar metamaterials that can mediate highly precise light-matter interactions. Because of their unique optical properties, both plasmonic and dielectric metasurfaces have found common use in sensing applications, enabling label-free, nondestructive, and miniaturized sensors with ultralow limits of detection. However, because bare metasurfaces inherently lack target specificity, their applications have driven the development of surface modification techniques that provide selectivity. Both chemical functionalization and physical texturing methodologies can modify and enhance metasurface properties by selectively capturing analytes at the surface and altering the transduction of light-matter interactions into optical signals. This review summarizes recent advances in material-specific surface functionalization and texturing as applied to representative optical metasurfaces. We also present an overview of the underlying chemistry driving functionalization and texturing processes, including detailed directions for their broad implementation. Overall, this review provides a concise and centralized guide for the modification of metasurfaces with a focus toward sensing applications.
Publisher: Wiley
Date: 04-08-2022
Abstract: The development of nanoscale optical sensors is desirable for a broad range of applications, including wearable medical‐diagnostics, biochemical detection, and environmental monitoring. Optical detection platforms based on resonant nanostructures are the golden standard for miniaturized footprint and high optical sensitivity. These sensors function by measuring a shift in resonance wavelength upon binding of analytes to their surface. However, such measurements are sensitive to intensity fluctuations of the illuminating source and its wavelength calibration, which limits their applicability. Here, a novel optical sensing concept based on diffraction measurements from resonant dielectric metagratings is proposed and experimentally demonstrated. It is shown that this approach enables the direct measurement of unknown analytes with enhanced sensitivity and without the need for intensity calibrations. The intensified sensitivity of this metagrating‐sensor is derived from combining the resonant phenomena of the nanostructures with the tailored diffraction from the metagrating, thereby providing the highest sensitivity demonstrated to date amongst grating‐based sensors. As a proof of concept, the metagrating‐sensor was validated using an antibody binding assay, achieving a femtomolar‐level limit of detection. Due to their high sensitivity and robust performance, the proposed metagrating sensors pave the way for novel miniaturized medical diagnostics and biosensing applications.
No related grants have been discovered for Shridhar Manjunath.