ORCID Profile
0000-0002-2352-2130
Current Organisation
University of Texas at San Antonio
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Publisher: Elsevier BV
Date: 03-2019
Publisher: American Chemical Society (ACS)
Date: 08-07-2022
DOI: 10.1021/JACS.2C03376
Abstract: RibB (3,4-dihydroxy-2-butanone 4-phosphate synthase) is a magnesium-dependent enzyme that excises the C4 of d-ribulose-5-phosphate (d-Ru5P) as formate. RibB generates the four-carbon substrate for lumazine synthase that is incorporated into the xylene moiety of lumazine and ultimately the riboflavin isoalloxazine. The reaction was first identified by Bacher and co-workers in the 1990s, and their chemical mechanism hypothesis became canonical despite minimal direct evidence. X-ray crystal structures of RibB typically show two metal ions when solved in the presence of non-native metals and/or liganding non-substrate analogues, and the consensus hypothetical mechanism has incorporated this cofactor set. We have used a variety of biochemical approaches to further characterize the chemistry catalyzed by RibB from
Publisher: American Chemical Society (ACS)
Date: 19-07-2016
DOI: 10.1021/JACS.6B05134
Publisher: Elsevier BV
Date: 12-2016
Publisher: American Chemical Society (ACS)
Date: 27-09-2021
Publisher: Elsevier BV
Date: 11-2019
Location: United States of America
Location: United States of America
No related grants have been discovered for Audrey Lamb.