ORCID Profile
0000-0002-1051-2259
Current Organisation
Bu Ali Sina University
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Publisher: Walter de Gruyter GmbH
Date: 04-2015
Abstract: Growth differentiation factor 9 (GDF9) is a fecundity major gene affecting prolificacy in sheep. In the present study, genetic variation of a 380-bp fragment in GDF9 gene exon 1 was investigated in 100 Lori ewes. Single-strand conformational polymorphism (SSCP) and DNA sequencing methods were used to detect single nucleotide polymorphism (SNP) of the studied fragment. A SNP (g.306G A), known as G1 mutation, with two genotypes (GG and AG) was found in two different SSCP patterns of GDF9 gene exon 1, deducing an amino acid (AA) exchange (p.Arg87His). Frequencies of the AG and GG genotypes were 37.65% and 62.35%, respectively. Also, the estimated allelic frequencies for the A and G alleles were 18.825% and 81.175%, respectively. The observed nucleotide sequences were subjected to alignment analysis and it was found that the studied fragment had more than 99.7% similarity with some sequences reported for other breeds of sheep. Two different secondary and 3D protein structures were predicted for A and G alleles. Moreover, the A and G alleles had different isoelectric pH values (8.7 and 9, respectively). The observed genotypes tended to have a significant association with litter size (P .10) where average litter size of GG ewes was slightly (20%) higher than for AG animals. With respect to the results of the present study, it seems that more studies are needed to evaluate the mutations in other fragments of this gene or other genes in Lori sheep.
Publisher: Elsevier BV
Date: 02-2018
Publisher: Elsevier BV
Date: 07-2013
DOI: 10.1016/J.GENE.2013.03.133
Abstract: BMPR-1B and GDF9 genes are well known due to their important effects on litter size and mechanisms controlling ovulation rate in sheep. In the present study, polymorphisms of BMPR-1B gene exon 8 and GDF9 gene exon 1 were detected by single strand conformational polymorphism (SSCP) analysis and DNA sequencing methods in 100 Mehraban ewes. The PCR reaction forced to lify 140 and 380-bp fragments of BMPR-1B and GDF9 genes, respectively. Two single nucleotide polymorphisms (SNPS) were identified in two different SSCP patterns of BMPR-1B gene (CC and CA genotypes) that deduced one amino acid exchange. Also, two SNPS were identified in three different SSCP patterns of GDF9 gene (AA, AG and GG genotypes) that deduced one amino acid exchanges. Two different secondary structures of protein were predicted for BMPR-1B exon 8, but the secondary protein structures predicted for GDF9 exon 1 were similar together. The evaluation of the associations between the SSCP patterns and the protein structure changes with reproduction traits showed that BMPR-1B exon 8 genotypes have significant effects on some of reproduction traits but the GDF9 genotypes did not have any significant effect. The CA genotype of BMPR-1B exon 8 had a significant positive effect on reproduction performance and could be considered as an important and new mutation, affecting the ewes reproduction performance. Marker assisted selection using BMPR-IB gene could be noticed to improve the reproduction traits in Mehraban sheep.
Publisher: Wiley
Date: 05-08-2018
DOI: 10.1111/AGE.12700
Abstract: Several causative mutations in candidate genes affecting prolificacy have been detected in various sheep breeds. A genome-wide association study was performed on estimated breeding values for litter size in Lori-Bakhtiari sheep. Prolific ewes with twinning records and others with only singleton records were genotyped using the medium-density Illumina Ovine SNP50 array. Four single nucleotide polymorphisms (SNPs) associated with litter size were identified on chromosomes 3, 6 and 22. The region on sheep chromosome 3 between 75 739 167 and 75 745 152 bp included two significant SNPs (s52383.1 and OAR3_80038014_X.1) in high linkage disequilibrium with each other. The region that surrounds these SNPs contains a novel putative candidate gene: luteinizing hormone/choriogonadotropin receptor (LHCGR), known to be involved in ovarian steroidogenesis and organism-specific biosystem pathways in sheep. Known prolificacy genes BMPR1B, BMP15 and GDF9 were not associated with litter size in Lori-Bakhtiari sheep, suggesting that other biological mechanisms could be responsible for the trait's variation in this breed.
Publisher: Elsevier BV
Date: 2019
Publisher: Wiley
Date: 05-08-2016
DOI: 10.1111/RDA.12733
Abstract: Ovulation rate and litter size are important reproduction traits in sheep and are of high economic value. Reproduction traits typically have low to medium heritabilities and do not exhibit a noticeable response to phenotypic selection. Therefore, inclusion of genetic information of the genes associated with reproductive ability could efficiently enhance the selection response. The most important major genes affecting prolificacy and their genetic ersities in different sheep breeds were reviewed. Different causative mutations with major effects on reproductive traits including ovulation rate and litter size have been found in various sheep breeds around the world. A general overview of the studies on main prolificacy genes showed that some alleles may express different phenotypic effects in different breeds, and thus, further studies on epistatic effects are necessary for more understanding of genetic control of reproductivity in sheep. Regarding the polygenic control of fertility traits, application of new high-throughput technologies to find new variants is essential for future studies. Moreover, genomewide association studies and genomic best linear unbiased predictions of breeding values are likely to be effective tools for genetic improvement of sheep reproductive performance traits.
Publisher: Springer Science and Business Media LLC
Date: 10-04-2015
DOI: 10.1007/S11250-015-0799-2
Abstract: Some mutations in bone morphogenetic protein 15 (BMP15) gene have been known to be associated with prolificacy in various breeds of sheep. Polymorphism of BMP15 gene exon 2 was studied in 100 Mehraban and 100 Lori ewes, using PCR-SSCP and DNA sequencing methods. A new point mutation (G → A) was found at position 57 of the lified 312-b fragment of BMP15 gene exon 2. The frequencies of the AG and GG genotypes were 69.4 and 30.6 % in Mehraban and 44.7 and 55.3 % in Lori ewes, respectively. No in idual carrying the AA genotype was found in the studied population. The allelic frequencies for A and G alleles were 34.7 and 65.3 % in Mehraban and 22.4 and 77.6 % in Lori ewes, respectively. Average litter size in the AG genotype (1.56) was significantly (P < 0.01) higher than the GG ewes (1.08). The results of the present study indicated the potential of the observed SNP in exon 2 of BMP15 for further exploitation in marker-assisted selection to improve reproduction efficiency of Mehraban and Lori sheep.
Publisher: Springer Science and Business Media LLC
Date: 04-04-2023
Publisher: Informa UK Limited
Date: 02-2018
DOI: 10.1080/17476348.2018.1433034
Abstract: Cardiorespiratory physiotherapy is an evidence-based practice that has evolved alongside changes in medical and surgical management, analgesia, the ageing society and increasing comorbidities of our patient populations. Continued research provides the profession with the ability to adapt to meet the changing patient and community needs. Areas covered: This review focuses on surgical, respiratory and critical care settings discussing the most significant changes over the past decade with an increased focus on rehabilitation across the care continuum and a shift away from providing predominately airway clearance in established disease populations but also providing this in emerging groups. Further important changes are identification and emphases on patient self-management including changing their behaviour to more positively embrace wellness, particularly increasing physical activity levels. This paper outlines these changes and offers speculation on factors that may impact the profession in the future. Expert commentary: The increasing focus on new technologies, physical activity levels, changes to the health systems in different countries and an increasingly comorbid and ageing society will shape the next steps in the evolution of cardiorespiratory physiotherapy. Continued research is vital to keep pace with these changes so that physiotherapists can provide the most effective treatments to improve patient outcomes.
Publisher: Universidade Estadual de Maringa
Date: 30-04-2018
Publisher: Springer Science and Business Media LLC
Date: 09-05-2019
No related grants have been discovered for Pouya Zamani.