ORCID Profile
0000-0001-9498-8774
Current Organisations
University of Queensland
,
Monash University - Caulfield Campus
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: SAGE Publications
Date: 08-05-2019
Abstract: Scholarly publishing has undergone major changes over the past 50 years. Funder mandates and organisational reporting obligations have heralded the creation of open access repositories, such as institutional and subject repositories. This research draws upon the US PubMed Central (PMC) and Europe PMC, also known as PMC International, as a role model to inform the concept and opportunity for an Australasia open access biomedical repository. PMC International is a leader in making citations and research output, which link to research data, Findable, Accessible, Interoperable and Reusable (FAIR). As repositories approach two decades of development, this paper reports on the potential for an Australasia open access biomedical repository through a knowledge management lens and explores the opportunities for future open access biomedical repositories.
Publisher: Frontiers Media SA
Date: 14-11-2018
Publisher: Cold Spring Harbor Laboratory
Date: 31-05-2017
DOI: 10.1101/144386
Abstract: Pest insects are increasingly resistant to phosphine gas, which is used globally to protect grain reserves. The enzyme dihydrolipoamide dehydrogenase (DLD) is a phosphine resistance factor and participates in four key steps of core metabolism, making it a potential central metabolic regulator. Here we used microarray data and NMR-based metabolomics to characterize the phosphine response of wild-type C. elegans and the phosphine-resistant strain dld-1 ( wr4 ) which has a partial loss-of-function mutation in the gene for DLD. In addition, we have constructed Ce Con, a C. elegans genome-scale metabolic model to facilitate integration of gene expression and metabolomics data. The resulting systems biology analysis is consistent with the hypothesis that adaptation to a hypometabolic state is the most prominent mechanism of phosphine resistance in this nematode strain. The involvement of DLD in regulating and creating hypometabolic adaptation has implications for other biological phenomena involving hypometabolism, such as reperfusion injury and metabolic resistance.
Publisher: Informa UK Limited
Date: 03-04-2017
Publisher: Springer US
Date: 2020
DOI: 10.1007/978-1-0716-0239-3_18
Abstract: Interpretation of metabolomics data in the context of biological pathways is important to gain knowledge about underlying metabolic processes. In this chapter we present methods to analyze genome-scale models (GSMs) and metabolomics data together. This includes reading and mining of GSMs using the SBTab format to retrieve information on genes, reactions, and metabolites. Furthermore, the chapter showcases the generation of metabolic pathway maps using the Escher tool, which can be used for data visualization. Lastly, approaches to constrain flux balance analysis (FBA) by metabolomics data are presented.
Publisher: Public Library of Science (PLoS)
Date: 22-02-2019
Publisher: Springer Science and Business Media LLC
Date: 20-09-2016
No related grants have been discovered for Jake Hattwell.