ORCID Profile
0000-0003-1326-6054
Current Organisations
McGill University
,
Université de Technologie de Belfort-Montbéliard
,
University of Kansas
,
Ecole de technologie superieure
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Publications
Characterizing white matter changes in chronic schizophrenia: A free-water imaging multi-site study
Publisher: Elsevier BV
Date: 11-2017
Enlarged lateral ventricles inversely correlate with reduced corpus callosum central volume in first episode schizophrenia: association with functional measures
Publisher: Springer Science and Business Media LLC
Date: 17-12-2015
Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
Publisher: Springer Science and Business Media LLC
Date: 17-10-2017
DOI: 10.1038/MP.2017.170
Cell type-specific manifestations of cortical thickness heterogeneity in schizophrenia
Publisher: Springer Science and Business Media LLC
Date: 10-02-2022
DOI: 10.1038/S41380-022-01460-7
Abstract: Brain morphology differs markedly between in iduals with schizophrenia, but the cellular and genetic basis of this heterogeneity is poorly understood. Here, we sought to determine whether cortical thickness (CTh) heterogeneity in schizophrenia relates to interregional variation in distinct neural cell types, as inferred from established gene expression data and person-specific genomic variation. This study comprised 1849 participants in total, including a discovery (140 cases and 1267 controls) and a validation cohort (335 cases and 185 controls). To characterize CTh heterogeneity, normative ranges were established for 34 cortical regions and the extent of deviation from these ranges was measured for each in idual with schizophrenia. CTh deviations were explained by interregional gene expression levels of five out of seven neural cell types examined: (1) astrocytes (2) endothelial cells (3) oligodendrocyte progenitor cells (OPCs) (4) excitatory neurons and (5) inhibitory neurons. Regional alignment between CTh alterations with cell type transcriptional maps distinguished broad patient subtypes, which were validated against genomic data drawn from the same in iduals. In a predominantly neuronal/endothelial subtype (22% of patients), CTh deviations covaried with polygenic risk for schizophrenia (sczPRS) calculated specifically from genes marking neuronal and endothelial cells ( r = −0.40, p = 0.010). Whereas, in a predominantly glia/OPC subtype (43% of patients), CTh deviations covaried with sczPRS calculated from glia and OPC-linked genes ( r = −0.30, p = 0.028). This multi-scale analysis of genomic, transcriptomic, and brain phenotypic data may indicate that CTh heterogeneity in schizophrenia relates to inter-in idual variation in cell-type specific functions. Decomposing heterogeneity in relation to cortical cell types enables prioritization of schizophrenia subsets for future disease modeling efforts.
A New MRI Masking Technique Based on Multi‐Atlas Brain Segmentation in Controls and Schizophrenia: A Rapid and Viable Alternative to Manual Masking
Publisher: Wiley
Date: 20-11-2015
DOI: 10.1111/JON.12313
Diffusion abnormalities in the corpus callosum in first episode schizophrenia: Associated with enlarged lateral ventricles and symptomatology
Publisher: Elsevier BV
Date: 07-2019
Fiber geometry in the corpus callosum in schizophrenia: Evidence for transcallosal misconnection
Publisher: Elsevier BV
Date: 10-2011
White matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis
Publisher: Springer Science and Business Media LLC
Date: 24-05-2021
Abnormal relationships between local and global brain measures in subjects at clinical high risk for psychosis: a pilot study
Publisher: Springer Science and Business Media LLC
Date: 16-08-2017
Related Organisations
Related Funding Activities
No related grants have been discovered for Sylvain Bouix.