ORCID Profile
0000-0002-4184-0175
Current Organisations
University of Sussex
,
Istituto di Fisiologia Clinica CNR
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Publisher: Elsevier BV
Date: 06-2015
DOI: 10.1016/J.BMCL.2015.04.055
Abstract: In the present work, we report the synthesis of new aryliodonium salts used as precursors of single-stage nucleophilic (18)F radiofluorination. The corresponding unlabelled fluorinated derivatives showed to be CB2 cannabinoid receptor specific ligands, with Ki values in the low nanomolar range and high CB2/CB1 selectivity. The radiolabelled compound [(18)F]CB91, was successfully formulated for in vivo administration, and its preliminary biodistribution was assessed with microPET/CT. This tracer presented a reasonable in vivo stability and a preferential extraction in the tissues that constitutionally express CB2 cannabinoid receptor. The results obtained indicate [(18)F]CB91 as a possible candidate marker of CB2 cannabinoid receptor distribution. This study would open the way to further validation of this tracer for assessing pathologies for which the expression of this receptor is modified.
Publisher: Elsevier BV
Date: 12-2011
DOI: 10.1016/J.APRADISO.2011.02.037
Abstract: The present study focuses on a micro-PET/CT application to be used for experimental Boron Neutron Capture Therapy (BNCT), which integrates, in the same frame, micro-CT derived anatomy and PET radiotracer distribution. Preliminary results have demonstrated that (18)F-fluoroethyl-tyrosine (FET)/PET allows the identification of the extent of cerebral lesions in F98 tumor bearing rat. Neutron autoradiography and α-spectrometry on axial tissues slices confirmed the tumor localization and extraction, after the administration of fructose-boronophenylalanine (BPA). Therefore, FET-PET approach can be used to assess the transport, the net influx, and the accumulation of FET, as an aromatic amino acid analog of BPA, in experimental animal model. Coregistered micro-CT images allowed the accurate morphological localization of the radiotracer distribution and its potential use for experimental BNCT.
Publisher: University of Westminster Press
Date: 12-06-2020
DOI: 10.16997/ESLJ.245
Abstract: This research article critically engages with the Licensing Act (2003), arguing for a more holistic approach to licensing. Drawing on primary research conducted in London for the Greater London Authority (GLA), the article considers the benefits of licensed venues and the possibility of extending current licensing objectives to recognise the role of these venues in sustaining urban vitality. The current licensing objectives are geared towards minimising negative outcomes, the assumption being that licensing is primarily a tool of control, with the role of minimising harm. The argument developed here is based on two alternative conceptions of the role of licensing. Firstly, licensing has a key role to play in developing sites for sociability and community cohesion. Though focused around alcohol, licensing is central to enabling or constraining more traditional as well as emerging spaces which combine entertainment, dining and other experimental forms of leisure. Second, the article argues that by addressing urban vitality and cultural benefit, the Act could be more attuned to the positive influence of licensed premises on a broader scale. The need for planning and licensing to work more cooperatively is considered in light of how licensing decisions reach beyond in idual venues and impact on entire neighbourhoods or areas. Focusing on two London boroughs, Croydon and Lambeth, the paper examines how the current approach to licensing by local authorities could therefore be re-framed in more positive terms to acknowledge the wider cultural benefits and social good of licensed premises.
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Daniele Panetta.