ORCID Profile
0000-0002-1925-9755
Current Organisation
Diponegoro University
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Publisher: Institute of Research and Community Services Diponegoro University (LPPM UNDIP)
Date: 30-11-2022
Abstract: Latar Belakang: Angka kematian ibu (AKI) adalah masalah yang masih menjadi perhatian khusus di Indonesia. Preekl sia adalah suatu komplikasi dalam kehamilan yang menjadi salah satu penyebab utama mortalitas ibu dan janin di seluruh dunia. Preekl sia pun merupakan penyakit yang seringkali menyebabkan seorang ibu hamil memerlukan perawatan hingga di intensive care unit (ICU). Paparan timbal merupakan faktor risiko penting kejadian preekl sia, dimana ibu hamil dengan preekl sia memiliki kadar timbal darah lebih tinggi secara signifikan dari rata – rata kehamilan normal. Penurunan kadar Antioksidan juga secara konsisten berhubungan dengan kejadian preekl sia. Dibutuhkan pengkajian lebih lanjut mengenai hubungan antara kadar timbal darah dengan status antioksidan pada pasien preekl sia.Tujuan: Untuk mengetahui dan menganalisis kadar timbal sebagai faktor risiko terhadap peningkatan kadar superoxide dismutase (SOD).Metode: Penelitian ini merupakan penelitian observasi analitik dengan metode case control pada 46 ibu hamil dengan preekl sia yang berobat di RSUD Kabupaten Brebes. Dilakukan pemeriksaan kadar timbal darah dengan metode SSA dan SOD serum dengan metode enzyme linked imunosorben assay (ELISA).Hasil: Rerata kada Pb darah dalam penelitian ini adalah 42,35 μg/dl, sedangkan rerata kadar SOD serum adalah 118,43 U/L. Analisis statistik dengan uji korelasi spearman menunjukan tidak terdapat hubungan yang signifikan antara kadar Pb darah dengan SOD serum (r = -0,263, p = 0,078).Kesimpulan: Kadar Pb darah tidak cukup mempengaruhi kadar SOD serum pada pasien Preekl sia.
Publisher: Secretariat of The Indonesian Biomedical Journal
Date: 30-04-2019
Abstract: BACKGROUND: Inflammation plays an important role in the atherosclerotic process. High-sensitivity C-reactive-protein (hs-CRP) is commonly used as inflammatory biomarker. It is well known that regular physical activity lowers hs-CRP levels, while prolonged exercise induces hs-CRP elevations. However, the relationship of training and exercise characteristics with hs-CRP levels remains not well elucidated. We evaluated baseline and post-exercise hs-CRP levels and its association with training and exercise characteristics.METHODS: Eighty-eight male endurance cyclists were involved. Demographic data, health condition and training characteristics were collected. Baseline and postexercise blood-s les were collected to determine hsCRP concentrations. A hs-CRP cut-off point of 3 mg/L was used. Blood-cell count and biochemical parameters were measured at baseline. Heart rate (HR) was measured during exercise.RESULTS: Cyclists performed 7.3 hours (interquartilerange (IQR) = 5.4-7.5) of endurance exercise at intensity of 81.8 % (IQR = 74.9-85.8). Cyclists with baseline hsCRP ≥ 3 mg/L reported higher body mass, body mass index (BMI), waist-circumference and total-cholesterol. An increase in hs-CRP was following endurance exercise. Cyclists with any elevation of hs-CRP reported a higher BMI, HR during exercise and exercise intensity. Binary logistic regression analysis showed BMI (OR = 1.24, 95% CI = 1.04-1.48) and cycling distance (OR = 0.22, 95% CI = 0.06-0.76) were associated with post-exercise hs-CRP elevations.CONCLUSION: Body mass, BMI, waist-circumference, total- and HDL-cholesterol are associated with baseline hsCRP, whereas BMI and cycling distance were associated with hs-CRP elevations. These findings suggest that anthropometry parameters and lipid levels attributed to baseline hs-CRP, while anthropometry parameters and cycling intensity attributed to post-exercise hs-CRP elevations.KEYWORDS: C-reactive-protein, exercise, endurancecycling, inflammation, acute-phase-response
Publisher: Springer Science and Business Media LLC
Date: 08-06-2019
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