ORCID Profile
0000-0003-1259-9922
Current Organisations
Universidade de Lisboa Faculdade de Medicina
,
Universidade de Lisboa
,
Hospital de Santa Maria
,
Instituto de Medicina Molecular
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Publications
Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis
Publisher: American Society of Clinical Oncology (ASCO)
Date: 20-07-2016
Abstract: Posterior fossa ependymoma comprises two distinct molecular variants termed EPN_PFA and EPN_PFB that have a distinct biology and natural history. The therapeutic value of cytoreductive surgery and radiation therapy for posterior fossa ependymoma after accounting for molecular subgroup is not known. Four independent nonoverlapping retrospective cohorts of posterior fossa ependymomas (n = 820) were profiled using genome-wide methylation arrays. Risk stratification models were designed based on known clinical and newly described molecular biomarkers identified by multivariable Cox proportional hazards analyses. Molecular subgroup is a powerful independent predictor of outcome even when accounting for age or treatment regimen. Incompletely resected EPN_PFA ependymomas have a dismal prognosis, with a 5-year progression-free survival ranging from 26.1% to 56.8% across all four cohorts. Although first-line (adjuvant) radiation is clearly beneficial for completely resected EPN_PFA, a substantial proportion of patients with EPN_PFB can be cured with surgery alone, and patients with relapsed EPN_PFB can often be treated successfully with delayed external-beam irradiation. The most impactful biomarker for posterior fossa ependymoma is molecular subgroup affiliation, independent of other demographic or treatment variables. However, both EPN_PFA and EPN_PFB still benefit from increased extent of resection, with the survival rates being particularly poor for subtotally resected EPN_PFA, even with adjuvant radiation therapy. Patients with EPN_PFB who undergo gross total resection are at lower risk for relapse and should be considered for inclusion in a randomized clinical trial of observation alone with radiation reserved for those who experience recurrence.
Divergent clonal selection dominates medulloblastoma at recurrence
Publisher: Springer Science and Business Media LLC
Date: 2016
DOI: 10.1038/NATURE16478
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma
Publisher: Springer Science and Business Media LLC
Date: 27-04-2020
Intertumoral Heterogeneity within Medulloblastoma Subgroups
Publisher: Elsevier BV
Date: 06-2017
MIGRATION AND THE TRANS-NATIONALISATION OF AFRICAN PENTECOSTALISM IN EUROPE
Publisher: Scholar Publishing
Date: 13-01-2020
Abstract: Migration, the movement of people from one geographical location to another is an indispensable component of globalisation which has impacted the latter with visible effects. Neo-Pentecostal Christian movements from different parts of Africa have seized the advantage of both migration and globalization to advance their missionary causes. This has resulted in planting new churches and organization of para-church ministries and outreaches in different parts of Europe and elsewhere. Using the Critical Integrated Analysis (CIA) method, which seeks to generate data from the existing body of knowledge, the article explored the trajectories of African migration vis-à-vis the penetration of African-led Pentecostal churches in some part of Europe. This process has stemmed encounters between the European and African cultures plus the hurdle of navigating the cultural nuances of the Europeans. The article discovered that although there are shreds of evidence of growth among African-led migrant churches, more grounds need to be covered. It suggested that migrant churches need to structure their ministries and organisations in ways that propel appropriate cultural engagement with their host communities to enable them to influence and transform their immediate social realities.
Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma
Publisher: Elsevier BV
Date: 06-2020
Related Organisations
Related Funding Activities
No related grants have been discovered for Claudia Faria.