ORCID Profile
0000-0002-7005-0025
Current Organisations
Universitas Airlangga Fakultas Kedokteran
,
University of Queensland School of Medicine
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Publisher: F1000 Research Ltd
Date: 23-12-2022
DOI: 10.12688/F1000RESEARCH.125551.2
Abstract: Introduction: Health literacy on the coronavirus disease 2019 (COVID-19) affects people’s capability to ascertain their health and health care quality during the pandemic. The objective of this study was to determine the levels of health literacy about COVID-19 vaccines and vaccinations (Vaccines and Vaccinations literacy-VL) in the Indonesian adult general population, assessing the perceptions of the respondents about current adult immunization and beliefs about vaccinations in general, and analyzing correlations of these variables with the VL levels. Methods: A cross-sectional study using a rapid survey was administered via the Internet. Data were analyzed using descriptive and inferential statistics the internal consistency of the VL scales was evaluated using Cronbach’s alpha coefficient the inter-correlation between the functional and interactive-critical VL questions, the underlying components (factors) and each question’s load on the components were identified using a Principal Component Analysis (PCA). An alpha level lesser than 0.05 was considered significant. Results: Responses to functional- and interactive/ critical- VL questions were acceptable and showed internal consistency (Cronbach’s alpha = 0.817 and 0.699, respectively), lowest values observed were 0.806 for functional scale and 0.640 for the interactive-critical scale. The PCA demonstrated that there were two components accounting for 52.45% of the total variability. Approximately 60% of respondents were females (n=686). Almost all respondents used the internet to seek information regarding COVID-19 and COVID-19 vaccinations. Many used at least one social media actively with 74.4% of respondents sometimes believing the validity of this information. Conclusions: High scores were observed in both functional- and interactive/ critical-VL, and were quite in a balance between sexes in the prior VL and higher in females for the latter these were also closely related to the educational level and age group. It is crucial to increase public health literacy in managing the pandemic.
Publisher: F1000 Research Ltd
Date: 21-08-2023
DOI: 10.12688/F1000RESEARCH.130610.1
Abstract: Background : Sentiments and opinions regarding COVID-19 and the COVID-19 vaccination on Indonesian-language Twitter are scarcely reported in one comprehensive study, and thus were aimed at our study. We also analyzed fake news and facts, and Twitter engagement to understand people’s perceptions and beliefs that determine public health literacy. Methods: We collected 3,489,367 tweets data from January 2020 to August 2021. We analyzed factual and fake news using the string comparison method. The difflib library was used to measure similarity. The user's engagement was analyzed by averaging the engagement metrics of tweets, retweets, favorites, replies, and posts shared with sentiments and opinions regarding COVID-19 and COVID-19 vaccination. Result: Positive sentiments on COVID-19 and COVID-19 vaccination dominated, however, the negative sentiments increased during the beginning of the implementation of restrictions on community activities (PPKM). The tweets were dominated by the importance of health protocols (washing hands, keeping distance, and wearing masks). Several types of vaccines were on top of the word count in the vaccine subtopic. Acceptance of the vaccination increased during the studied period, and the fake news was overweighed by the facts. The tweets were dynamic and showed that the engaged topics were changed from the nature of COVID-19 to the vaccination and virus mutation which peaked in the early and middle terms of 2021. The public sentiment and engagement were shifted from hesitancy to anxiety towards the safety and effectiveness of the vaccines, whilst changed again into wariness on an uprising of the delta variant. Conclusion: Understanding public sentiment and opinion can help policymakers to plan the best strategy to cope with the pandemic. Positive sentiments and fact-based opinions on COVID-19, and COVID-19 vaccination had been shown predominantly. However, sufficient health literacy levels could yet be predicted and sought for further study.
Publisher: Institute of Advanced Engineering and Science
Date: 03-2021
DOI: 10.11591/IJPHS.V10I1.20554
Abstract: We explored association between the levels of total cholesterol (TC) and uric acid (UA) to the middle upper arm circumference (MUAC), waist circumference (WC) and hip circumference (HC) amongst seemingly healthy university students in Kediri, Indonesia aged 17-23 years (n=150) no history of major previous diseases were found (i.e. metabolic syndrome). TC and UA measured from the capillary blood standardised anthropometry measurements were done by trained medical doctors. Correlation, linear regression, independent t-test or Mann-Whitney analysis were performed with the level of significance of p& .05. We found higher TC (p=0.053), UA (p& .001), MUAC (p=0.009), HC (p=0.865) and WC (p=0.001) among males than among females. TC was significantly correlated to the UA with prevalence of hypercholesterolemia of 46.7% and hyperuricemia of 30% of all participants. All anthropometry was significantly correlated to the TC and UA among males (p& .001) TC and UA were strongly corresponded to all anthropometry parameters among males. Hypercholesterolemia and hyperuricemia could be found amongst the seemingly healthy young adults in Indonesia among males these are strongly correlated to the higher MUAC, WC and HC. Daily physical activity and proper healthy diet might help to decrease these cardiovascular disease risk factors.
Publisher: S. Karger AG
Date: 2011
DOI: 10.1159/000326630
Abstract: The principal function of the γ-aminobutyric acid (GABA) system in the adult brain is inhibition however, in the neonatal brain, GABA provides much of the excitatory drive. As the brain develops, transmembrane chloride gradients change and the inhibitory role of GABA is initiated and continues throughout juvenile and adult life. Previous studies have shown that GABA sub A /sub receptor subunit expression is developmentally regulated, and it is thought that the change in GABA function from excitation to inhibition corresponds to the changeover in expression of ‘immature’ to ‘mature’ subunit isoforms. We examined the protein expression pattern and distribution of GABA type A (GABA sub A /sub ) receptor α sub /sub -, α sub /sub - and β sub /sub -subunits in the parietal cortex and hippoc us of the developing piglet brain. Four perinatal ages were studied 14 days preterm (P–14), 10 days preterm (P–10), day of birth (P0) and at postnatal day 7 (P7). Animals were obtained by either caesarean section or spontaneous birth. Protein expression levels and subunit localization were analysed by Western blotting and immunohistochemistry, respectively. In the cortex and hippoc us, GABA sub A /sub receptor α sub /sub -subunit showed greatest expression at P7 when compared to all other age groups (p 0.05). In contrast, α sub /sub expression in the cortex was elevated in preterm brain, peaking at P0, followed by a significant reduction by P7 (p 0.05) a similar trend was observed in the hippoc us. GABA sub A /sub receptor β sub /sub -subunit protein expression appeared relatively constant across all time points studied in both the cortex and hippoc us. Immunolabelling of the α sub /sub -, α sub /sub - and β sub /sub -subunits was observed throughout all cortical layers at every age. GABA sub A /sub receptor α sub /sub -subunit appeared to show specific localization to layers V and VI whilst labelling for the β sub /sub -subunit was observed in layer IV. In the hippoc us of all animals, the α sub /sub - and β sub /sub -subunits were shown to immunolabel various cells and processes in the dentate gyrus (DG), CA1 and CA3 the α sub /sub -subunit was barely observed except at the stratum moleculare of the DG. We report for the first time the ontogenesis of GABA sub A /sub receptor subunits α sub /sub , α sub /sub and β sub /sub in the perinatal pig brain.
Publisher: F1000 Research Ltd
Date: 11-11-2022
DOI: 10.12688/F1000RESEARCH.125551.1
Abstract: Introduction: Health literacy on the coronavirus disease 2019 (COVID-19) affects people’s capability to ascertain their health and health care quality during the pandemic. The objective of this study was to determine the levels of health literacy about COVID-19 vaccines and vaccinations (Vaccines and Vaccinations literacy-VL) in the Indonesian adult general population, assessing the perceptions of the respondents about current adult immunization and beliefs about vaccinations in general, and analyzing correlations of these variables with the VL levels. Methods: A cross-sectional study using a rapid survey was administered via the Internet. Data were analyzed using descriptive and inferential statistics the internal consistency of the VL scales was evaluated using Cronbach’s alpha coefficient the inter-correlation between the functional and interactive-critical VL questions, the underlying components (factors) and each question’s load on the components were identified using a Principal Component Analysis (PCA). An alpha level lesser than 0.05 was considered significant. Results: Responses to functional- and interactive/ critical- VL questions were acceptable and showed internal consistency (Cronbach’s alpha = 0.817 and 0.699, respectively), lowest values observed were 0.806 for functional scale and 0.640 for the interactive-critical scale. The PCA demonstrated that there were two components accounting for 52.45% of the total variability. Approximately 60% of respondents were females (n=686). Almost all respondents used the internet to seek information regarding COVID-19 and COVID-19 vaccinations. Many used at least one social media actively with 74.4% of respondents sometimes believing the validity of this information. Conclusions: High scores were observed in both functional- and interactive/ critical-VL, and were quite in a balance between sexes in the prior VL and higher in females for the latter these were also closely related to the educational level and age group. It is crucial to increase public health literacy in managing the pandemic.
Publisher: Frontiers Media SA
Date: 2016
Publisher: SCITEPRESS - Science and Technology Publications
Date: 2017
Publisher: Informa UK Limited
Date: 09-2023
DOI: 10.2147/OPTH.S426428
Publisher: Faculty of Medicine Universitas Indonesia
Date: 16-05-2018
Publisher: Faculty of Medicine, Universitas Indonesia
Date: 11-2012
Publisher: SciELO Agencia Nacional de Investigacion y Desarrollo (ANID)
Date: 03-2017
Publisher: S. Karger AG
Date: 2017
DOI: 10.1159/000468926
Abstract: GABA is a major neurotransmitter in the mammalian brain. In the mature brain GABA exerts inhibitory actions via the GABA sub A /sub receptor (GABA sub A /sub R) however, in the immature brain GABA provides much of the excitatory drive. We examined the expression of 3 predominant GABA sub A /sub α-subunit proteins in the pig brain at various pre- and postnatal ages. Brain tissue was collected from piglets born via caesarean section at preterm ages 91, 97, 100, and 104 days' gestational age (GA), at term equivalent (114 days' GA, caesarean section) and at term, postnatal day 0 (P0) (spontaneous delivery, term = 115 days). Tissue was obtained from piglets at P4 and P7. Adult tissue from sows was collected postmortem after caesarean section. In all cortical regions and basal ganglia (1) α sub /sub exhibited a significant increase in protein expression at 100 days' GA, (2) α sub /sub expression decreased with age after 100 days' GA, (3) α sub /sub increased with age, with peak expression at P7 in cortices, hippoc us, and thalamus, and (4) α sub /sub protein expression remained relatively constant across the ages examined. The subunit expression of α sub /sub was most abundant at preterm ages, with α sub /sub the predominant subunit expressed postnatally. Immunofluorescent labelling revealed α sub /sub expression on the somatic membranes of pyramidal cells in the cortex and hippoc us, and in the cerebellar Purkinje cells. Positive α sub /sub labelling was apparent on interneurones in the cortex and hippoc us. The switch between dominant α-subunits may coincide with the functional change in GABAergic neurotransmission from excitation to inhibition. Brain growth in the pig closely reflects that in the term human, making the pig a valuable non-primate model for studying development and the effects of insults on the perinatal brain.
Publisher: SciELO Agencia Nacional de Investigacion y Desarrollo (ANID)
Date: 03-2014
Publisher: Universitas Airlangga
Date: 05-03-2022
Abstract: Highlights: This article reports the use of the Y-maze as a simple yet effective method to measure spatial working memory in mice. The Y-maze method can be used safely without exposing the animals to additional stressors, as evidenced by the absence of mortality following the test. Abstract: Spatial working memory (SWM) in humans and animal models with impaired cognitive functions has been analyzed through a number of methods. However, this is still understudied in animal models treated with a high-calorie diet (HCD) and moderate-intensity exercise (MIE). The Y-maze was utilized as the assessment method in this study. A 40 x 9 x 9 cm3 Y-maze was employed to observe the animal models’ spontaneous alternation (SA) as the representation of their SWM. This was done by calculating the total alternation percentage ided by total entry minus two. A total of 17 female Mus musculus mice aged 8 weeks were tested in the Y-maze to investigate their SWM using SA calculations. Each mouse was analyzed for eight minutes and recorded in a dark and quiet room to minimize bias due to environmental noise and lighting. Comparing the treatment group’s (HCD+MIE) SA to the control group’s SA revealed no statistically significant difference (p=0.451). Seven mice in the treatment group performed similarly to the mice in the control group in the Y-maze test, with no significant difference in their ability to complete the task. The mice in the treatment group exhibited no motor impairment, as indicated by complete movements of all their extremities while exploring the Y-maze within the allotted time. In conclusion, the Y-maze can be used as a reliable method to analyze SWM in overweight/obese Mus musculus animal models treated with moderate-intensity physical exercise.
Publisher: Universitas Airlangga
Date: 29-03-2022
Abstract: Pendahuluan: Meningioma merupakan tumor otak primer yang berasal dari jaringan arakhnoid. Angka kejadian meningioma di Indonesia menunjukkan peningkatan dari tahun ke tahun. Selain mutasi gen supresor tumor, meningioma dapat dipengaruhi oleh faktor eksternal diantaranya usia dan jenis kelamin. Tujuan: Mengetahui hubungan antara usia dan jenis kelamin dengan angka kejadian meningioma pada pasien di RSUD Dr. Soetomo, Surabaya, Indonesia tahun 2018 berdasarkan derajat keganasannya. Metode: Penelitian ini merupakan studi observasional analitik cross-sectional retrospektif dari data sekunder lembar hasil pemeriksaan patologi anatomi pasien yang dirawat inap melalui SMF. Ilmu Bedah Saraf, RSUD Dr. Soetomo tahun 2018 data yang tidak lengkap akan dieksklusi. Analisis data dilakukan menggunakan uji Chi squre (SPSS 25) dengan tingkat signifikansi p ,05. Hasil: Didapatkan 45 pasien meningioma yang sesuai dengan kriteria inklusi, dengan mayoritas perempuan (71%) pada kelompok usia 45 – 49 tahun (22,2%), WHO grade I (82%) dengan tipe histopatologi transisional (49%). Terdapat hubungan yang signifikan antara angka kejadian meningioma dengan kelompok usia tertentu (r = 0,718, p = 0,025), dan dengan jenis kelamin (r = 0,441, p = 0,002). Rasio perempuan dibanding laki- laki sebesar 1:2,36. Kesimpulan: Usia dan jenis kelamin berkorelasi erat dengan angka kejadianmeningioma.
Publisher: Wiley
Date: 20-02-2017
DOI: 10.1016/J.IJDEVNEU.2017.02.004
Abstract: Intrauterine growth restriction (IUGR) is one of the most common causes of perinatal mortality and morbidity. White matter and neuronal injury are major pathophysiological features of the IUGR neonatal brain. GABA
Publisher: Frontiers Media SA
Date: 2016
Publisher: Universitas Airlangga
Date: 14-04-2021
Abstract: Overweight and obesity have been correlated to the higher risk for developing metabolic diseases in later life, i.e. DM type 2. We study the body mass index (BMI), the waist to hip ratio (WHR) and the fasting blood glucose levels (FBG) in the seemingly healthy male and female university students to comprehend these variables amongst the youth in Indonesia in 2019. The BMI and WHR of 150 male and female students aged 18-22 years old of the IIKBW, Kediri were measured by standardised anthropometry. The FBG was measured after 8 hours-minimum of fasting from the capillary blood drop using glucometer. Data was then analysed using SPSS 17 with level of significance of p .05. According to Asia-Pacific BMI classification, students were 30.7% obese with males significantly higher than females (p=0.016), 18% overweight (significantly higher in females, p=0.04), 36% normal and 15.3% underweight.When compared between genders, the WHR is significantly higher in males (p .001) whilst no significant differences in FBG (p=0.6). Four males and 5 females with FBG ≥ 100 mg/dl, whereas others were within normal limits. There are positive significant correlations between BMI and WHR in males and females (r=0.777, p .001 r=0.54, p .001, respectively). There is a significant positive correlation between the BMI and FBG with r=0.217, p=0.008 and between the WHR and FBG with r=0.21, p=0.01 amongst all students. In this study, male students have significantly higher BMI and WHR than females. Higher FBG was well observed in students with either higher BMI or WHR.
Publisher: Universitas Airlangga
Date: 31-07-2023
DOI: 10.20473/AKSONA.V3I2.46639
Abstract: Highlight: A dural tail sign was found in T1W1-MR-images with contrast of a patient with glioblastoma multiforme. Glioblastoma multiforme as a grade IV malignancy of the astrocytes' glioma, the dura mater can be infiltrated and shown as DTS, although rarely reported. ABSTRACT Introduction: The dural tail sign (DTS), which is rarely seen in patients with glioblastoma multiforme (GBM), is reported here. This sign is generally found as a manifestation of meningioma due to the reactive changes of the tumor’s invasion. Case: A 61-year-old Javanese man presented with a gradually worsening headache two months prior to hospital admission. He also suffered from paralysis of his right extremities. His complete blood tests and clinical chemistry were within normal limits. A head CT scan showed a large mass near the convexity of the brain in the left parietal lobe, along with edema and a shift of the midline structures to the right. This was confirmed on the T1W1 MR images with contrast, where DTS was clearly shown. Following surgical resection and tumor excision, histopathology analysis revealed GBM with malignant cell infiltration to the dura in the vicinity of the neoplasm. Conclusion: Here we showed a DTS in GBM as a malignant infiltration marker into the dura
Publisher: SCITEPRESS - Science and Technology Publications
Date: 2017
Publisher: Universitas Jenderal Soedirman
Date: 15-11-2022
DOI: 10.20884/1.JKS.2022.17.3.6572
Abstract: The rapid spread of information and infodemic might result in public confusion and hinder the handling of the COVID-19 pandemic. Public comprehension of COVID-19 as part of health literacy is an important determinant to filter hoaxes from facts. Therefore, a scoring card called the Karlivid (the COVID-19 literacy and public vaccination scorecard) was developed to evaluate the in idual’s comprehension level of COVID-19. A pilot study was conducted with this scoring card. The participants were recruited via consecutive random s ling by using emails from the researcher’s contact list (n=92). A total of 78.3% of the respondents were considered to have an adequate comprehension level. Approximately 77% of all respondents agreed that this card could help them know their comprehension level, 81.5% agreed that this card could improve their comprehension, 81.5% agreed that the items in this card could help them screen facts from hoaxes, and 81.5% agreed that the language used was easily understood by the laypersons. Therefore, the Karlivid is a valid and reliable scorecard that can be used to evaluate public comprehension of COVID-19. Most of the respondents also had a good level of comprehension of this assigned topic
Publisher: Exploratory Animal and Medical Research, West Bengal Veterinary Alumni Association
Date: 12-2022
Publisher: IOP Publishing
Date: 04-12-2018
Publisher: IOP Publishing
Date: 04-12-2018
Publisher: Springer Science and Business Media LLC
Date: 27-12-2017
DOI: 10.1007/S00429-017-1597-6
Abstract: The GABA
Publisher: Springer Science and Business Media LLC
Date: 11-2011
DOI: 10.1038/PR.2011.528
Publisher: Universitas Airlangga
Date: 07-03-2022
Abstract: Highlight:Moderate negative significant correlation between HbA1c and MCV levels in T2DM was yet reported widely.MCV levels could mirror health indicator in adult T2DM patients.Abstract:HbA1c showed the average level of blood sugar in the recent 2-3 months. This parameter can be used to help physicians to diagnose T2DM and to plan appropriate treatment. Meanwhile, the mean corpuscular volume (MCV) is established from the erythrocytes levels as one of the blood corpuscles, in which hemoglobin is bound to. We hypothesize that MCV is correlated to the HbA1c levels and could be an indicator of blood sugar levels in adult T2DM patients. A retrospective cross-sectional study based on the medical record of patients admitted to the Outpatient Section of Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Indonesia from January to December 2019 was done. Patients under 18-years old, and incomplete medical record data were excluded. Adult patients diagnosed with T2DM and have been received initial treatment in this section were included (n=1.688). Data was analyzed using correlation test in SPSS 17.0 (USA), p-value less than 0.05 was considered significant. We found a significant negative correlation between HbA1c and MCV levels in these patients (r=-0.312 p .001). MCV levels showed a paradoxical pattern against the blood glucose levels in T2DM and could serve as the health indicator in these patients.
Publisher: Universitas Airlangga
Date: 30-09-2023
Publisher: Springer Science and Business Media LLC
Date: 11-2019
Publisher: Public Library of Science (PLoS)
Date: 09-07-2013
Publisher: SCITEPRESS - Science and Technology Publications
Date: 2017
Publisher: Springer Science and Business Media LLC
Date: 26-02-2019
DOI: 10.1007/S11356-019-04601-8
Abstract: Mobile phones emit a radiofrequency radiation (RFR) that might have adverse health effects. We aimed to investigate the possible protective effects of aluminium foil (AF) as a physical shield against the RFR from mobile phones on the blood parameters and the myocardium in rats. The effects of whole body 2100 MHz with 0.84-1.86 W/kg of SAR, 4 h/day for 30 days Global System for Mobile Communications (GSM)-RFR exposure for 4 h/day for 30 days on blood parameters (i.e. haemoglobin, leucocytes, thrombocytes, erythrocyte sedimentation rate, white blood cell differential count, corticosterone, CKMB), and the histology of myocardium were investigated. Three-month-old male rats (n = 32) were studied and randomised equally in the following four groups: K1 (non-AF non-RFR control), K2 (AF non-RFR control), P1 (non-AF RFR-exposed), P2 (AF RFR-exposed). Data were analysed with level of significance of p < 0.05. In P1, lower leucocytes and neutrophils counts with high corticosterone levels were found compared with the control groups, whilst a significantly higher CKMB was observed compared with P2 (p = 0.034). Lower cardiomyocyte counts congruent to the area fraction of the non-fibrotic myocardium were observed in P1 compared with the other groups (p < 0.01). AF might decrease the inflammatory-oxidative stress on rodent's blood cells and myocardium induced by the exposures of radiofrequency radiation of the mobile phones.
Publisher: Informa UK Limited
Date: 15-07-2020
No related grants have been discovered for Viskasari P. Kalanjati.