ORCID Profile
0000-0001-8230-5649
Current Organisations
KU Leuven
,
Universitaire Ziekenhuizen Leuven
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Publisher: Informa UK Limited
Date: 10-02-2016
DOI: 10.3109/13880209.2015.1120320
Abstract: Context Melissa officinalis subsp. inodora Bornm. (Lamiaceae) has been used since ancient times in folk medicine against various diseases, but it has not been investigated against protozoa. Objective To evaluate the activities of M. officinalis against Leishmania braziliensis, Leishmania infantum and Trypanosoma cruzi as well as its cytotoxicity in fibroblast cell line. Materials and methods The fresh leaves were chopped into 1 cm(2) pieces, washed and macerated with 99.9% of ethanol for 72 h at room temperature. Antiparasitic activity of M. officinalis was accessed by direct counting of cells after serial dilution, while the cytotoxicity of M. officinalis was evaluated in fibroblast cell line (NCTC929) by measuring the reduction of resazurin. The test duration was 24 h. High-performance liquid chromatography (HPLC) was used to characterise the extract. Results The extract at concentrations of 250 and 125 μg/mL inhibited 80.39 and 54.27% of promastigote (LC50 value = 105.78 μg/mL) form of L. infantum, 80.59 and 68.61% of L. brasiliensis (LC50 value = 110.69 μg/mL) and against epimastigote (LC50 value = 245.23 μg/mL) forms of T. cruzi with an inhibition of 54.45 and 22.26%, respectively, was observed. The maximum toxicity was noted at 500 μg/mL with 95.41% (LC50 value = 141.01 μg/mL). The HPLC analysis identified caffeic acid and rutin as the major compounds. Discussion The inhibition of the parasites is considered clinically relevant (< 500 μg/mL). Rutin and caffeic acids may be responsible for the antiprotozoal effect of the extract. Conclusion The ethanol extract of M. officinalis can be considered a potential alternative source of natural products with antileishmania and antitrypanosoma activities.
Publisher: Hindawi Limited
Date: 2014
DOI: 10.1155/2014/838101
Abstract: Duguetia furfuracea is frequently used as a medicinal plant in Brazil. However, studies have evidenced its cytotoxic, bactericide, and antitumor activities. In the present study we aimed to evaluate the potential toxicity of hydroalcoholic leaves extracts of D. furfuracea (HEDF) in a Drosophila melanogaster model. Toxicity was assessed as changes in locomotor performance, mitochondrial activity, oxidative stress, MAPKs phosphorylation, and apoptosis induction after exposure to HEDF concentrations (1–50 mg/mL) for 7 days. The phytoconstituents of the plant were screened for the presence of alkaloids, tannins, xanthones, chalcones, flavonoids, aurones, and phenolic acids. Exposure of adult flies to HEDF caused mitochondrial dysfunction, overproduction of ROS, and alterations in the activity of detoxifying enzymes GST, SOD and CAT. Induction of ERK phosphorylation and PARP cleavage was also observed, indicating occurrence of HEDF-induced cell stress and apoptotic cell death. In parallel, alterations in cholinesterase activity and impairments in negative geotaxis behavior were observed. Our study draws attention to the indiscriminate use of this plant by population and suggests oxidative stress as a major mechanism underlying its toxicity.
Publisher: AME Publishing Company
Date: 11-2016
Publisher: Bentham Science Publishers Ltd.
Date: 12-2021
DOI: 10.2174/2213337208666210112162443
Abstract: The sole objective of the present study is to explore the research trends in photocatalysis. In this area, the first document was published in the year 1921 and until August 2020, a total of 6940 documents have been archived in the Scopus database. It is worthy to note that after 2000, a remarkable increase in publications has been noticed. In fact, 6605 articles have been published after 2000. The highest number of publications have been reported in 2019 (784/11.87% of 6605) followed by 2018 (740/11.20% of 6605) and 2017 (624/9.45% of 6605). We calculated the per year growth rate and doubling time of publications. In research publications, the top three (3) countries are China (3030/43.65%), USA (704/10.14%) and India (503/7.24%). We provided the details which may explain why China is the global leader in photocatalysis research. Furthermore, by Vosviewer analysis, we provided the coauthorship and citation details of only research articles and reviews (total 6197 documents). Based on the (a) number of publications and (b) citations, the list of top ten (10) authors, institutes, countries and source details are provided. We also performed the Vosviewer analysis for China’s publications (n=3030). The details about the top authors, institutes and collaborative countries are provided. One of the fundamental questions is: what has been covered in photocatalysis research articles and reviews (n=6197)? For this purpose, we manually analyzed 47,722 keywords and grouped them into different categories. Mostly the document covered research under the names of photocatalysis, semiconductors, photochemical sources, instrumental techniques, electrochemistry, nanomaterials and water treatment. We extended the idea and explored the research publications in selected semiconductors (like titanium, graphene, cadmium, bismuth and iron-based compounds), water purification, toxic pollutants, photocatalytic reduction of carbon dioxide, nanomaterials and certain specific instruments like SEM, TEM & XRD, etc.
Publisher: Bentham Science Publishers Ltd.
Date: 27-03-2017
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 29-08-2022
Publisher: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Date: 2017
Publisher: Elsevier BV
Date: 12-2016
DOI: 10.1016/J.BIOPHA.2016.09.089
Abstract: Eugenia uniflora is used in the Brazilian folk medicine to treat intestinal disorders and hypertension. However, scanty information exist on its potential toxicity to human, and little is known on its antioxidant activity in biological system. Hence, we investigated for the first time the potential toxic effects of ethanolic extract (EtOH) of E. uniflora (EEEU) in human leukocytes and erythrocytes, as well as its influence on membrane erythrocytes osmotic fragility. In addition, EEEU was chemically characterized and its antioxidant capacity was evaluated. We found that EEEU (1-480μg/mL) caused neither cytotoxicity nor DNA damage evaluated by Trypan blue and Comet assay, respectively. EEEU (1-480μg/mL) did not have any effect on membrane erythrocytes fragility. In addition, EEEU inhibited Fe
Location: China
Location: No location found
No related grants have been discovered for Lieven Depypere.