ORCID Profile
0000-0003-1569-2014
Current Organisations
University of Queensland
,
Imperial College London
,
Queensland University of Technology
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Neurocognitive Patterns and Neural Networks | Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) | Cognitive Science | Linguistic Processes (incl. Speech Production and Comprehension)
ANZSRC Socio-Economic Objective (SEO)
Nervous System and Disorders | Expanding Knowledge in Psychology and Cognitive Sciences | Hearing, Vision, Speech and Their Disorders |
Related Links
Publications
The contribution of the inferior parietal cortex to spoken language production
Publisher: Elsevier BV
Date: 04-2012
DOI: 10.1016/J.BANDL.2012.02.005
Abstract: This functional MRI study investigated the involvement of the left inferior parietal cortex (IPC) in spoken language production (Speech). Its role has been apparent in some studies but not others, and is not convincingly supported by clinical studies as they rarely include cases with lesions confined to the parietal lobe. We compared Speech with non-communicative repetitive tongue movements (Tongue). The data were analyzed with both univariate contrasts between conditions and probabilistic independent component analysis (ICA). The former indicated decreased activity of left IPC during Speech relative to Tongue. However, the ICA revealed a Speech component in which there was correlated activity between left IPC, frontal and temporal cortices known to be involved in language. Therefore, although net synaptic activity throughout the left IPC may not increase above baseline conditions during Speech, one or more local systems within this region are involved, evidenced by the correlated activity with other language regions.
A Step Forward for Mirror Neurons? Investigating the Functional Link between Action Execution and Action Observation in Limb Apraxia
Publisher: Society for Neuroscience
Date: 30-07-2008
Using fMRI and Behavioural Measures to Investigate Rehabilitation in Post-Stroke Aphasic Deficits
Publisher: Imperial College London
Date: 2013
DOI: 10.25560/15535
The contribution of the parietal lobes to speaking and writing
Publisher: Oxford University Press (OUP)
Date: 16-06-2010
The Visual Word Form System in Context
Publisher: Society for Neuroscience
Date: 05-01-2011
DOI: 10.1523/JNEUROSCI.2705-10.2011
Abstract: According to the “modular” hypothesis, reading is a serial feedforward process, with part of left ventral occipitotemporal cortex the earliest component tuned to familiar orthographic stimuli. Beyond this region, the model predicts no response to arrays of false font in reading-related neural pathways. An alternative “connectionist” hypothesis proposes that reading depends on interactions between feedforward projections from visual cortex and feedback projections from phonological and semantic systems, with no visual component exclusive to orthographic stimuli. This is compatible with automatic processing of false font throughout visual and heteromodal sensory pathways that support reading, in which responses to words may be greater than, but not exclusive of, responses to false font. This functional imaging study investigated these alternative hypotheses by using narrative texts and equivalent arrays of false font and varying the hemifield of presentation using rapid serial visual presentation. The “null” baseline comprised a decision on visually presented numbers. Preferential activity for narratives relative to false font, insensitive to hemifield of presentation, was distributed along the ventral left temporal lobe and along the extent of both superior temporal sulci. Throughout this system, activity during the false font conditions was significantly greater than during the number task, with activity specific to the number task confined to the intraparietal sulci. Therefore, both words and false font are extensively processed along the same temporal neocortical pathways, separate from the more dorsal pathways that process numbers. These results are incompatible with a serial, feedforward model of reading.
Language and language disorders: neuroscience to clinical practice
Publisher: BMJ
Date: 26-07-2019
DOI: 10.1136/PRACTNEUROL-2018-001961
Abstract: Language disorders are common in neurological practice but their accurate recognition and description can be challenging. In this review, we summarise the major landmarks in the understanding of language disorders and the organisation of language in the brain. We describe approaches to assessing language disorders at the bedside or in the clinic as well as the treatment and rehabilitation of aphasia. Finally, we describe how the field of neuroscience is providing new computational and neuroscientific approaches to study the mechanisms of recovery and rehabilitation of aphasia.
Efficacy of spoken word comprehension therapy in patients with chronic aphasia: a cross-over randomised controlled trial with structural imaging
Publisher: BMJ
Date: 05-11-2020
Abstract: The efficacy of spoken language comprehension therapies for persons with aphasia remains equivocal. We investigated the efficacy of a self-led therapy app, ‘Listen-In’, and examined the relation between brain structure and therapy response. A cross-over randomised repeated measures trial with five testing time points (12-week intervals), conducted at the university or participants' homes, captured baseline (T 1 ), therapy (T 2 -T 4 ) and maintenance (T 5 ) effects. Participants with chronic poststroke aphasia and spoken language comprehension impairments completed consecutive Listen-In and standard care blocks (both 12 weeks with order randomised). Repeated measures analyses of variance compared change in spoken language comprehension on two co-primary outcomes over therapy versus standard care. Three structural MRI scans (T 2 -T 4 ) for each participant (subgroup, n=25) were analysed using cross-sectional and longitudinal voxel-based morphometry. Thirty-five participants completed, on average, 85 hours (IQR=70–100) of Listen-In (therapy first, n=18). The first study-specific co-primary outcome (Auditory Comprehension Test (ACT)) showed large and significant improvements for trained spoken words over therapy versus standard care (11%, Cohen’s d=1.12). Gains were largely maintained at 12 and 24 weeks. There were no therapy effects on the second standardised co-primary outcome (Comprehensive Aphasia Test: Spoken Words and Sentences). Change on ACT trained words was associated with volume of pretherapy right hemisphere white matter and post-therapy grey matter tissue density changes in bilateral temporal lobes. In iduals with chronic aphasia can improve their spoken word comprehension many years after stroke. Results contribute to hemispheric debates implicating the right hemisphere in therapy-driven language recovery. Listen-In will soon be available on GooglePlay. NCT02540889 .
Corticostriatal Regulation of Language Functions
Publisher: Springer Science and Business Media LLC
Date: 12-05-2021
Grey matter density in the right caudate nucleus predicts aphasic patients’ response to speech comprehension therapy
Publisher: Frontiers Media SA
Date: 2018
Neighing dogs: Semantic context effects of environmental sounds in spoken word production - a replication and extension.
Publisher: SAGE Publications
Date: 21-11-2022
DOI: 10.1177/17470218221137007
Abstract: Semantic context effects are well established using both words and pictures as stimuli. One such effect, semantic interference, is observed in naming latencies when a categorically related distractor word or picture is presented together with a target picture (e.g., dog-LION). Recently, this effect has also been shown to occur when an environmental sound (e.g., a dog
Language deficits following dominant hemisphere tumour resection are significantly underestimated by syndrome-based aphasia assessments
Publisher: Informa UK Limited
Date: 26-05-2019
Brain Lesions Associated with Communication-Related Quality of Life Following Surgical Removal of Primary Left-Hemisphere Tumours
Publisher: Informa UK Limited
Date: 28-11-2022
Cognitive control and its impact on recovery from aphasic stroke
Publisher: Oxford University Press (OUP)
Date: 24-10-2013
DOI: 10.1093/BRAIN/AWT289
Semantic memory: Which side are you on?
Publisher: Elsevier BV
Date: 09-2015
DOI: 10.1016/J.NEUROPSYCHOLOGIA.2014.11.024
Abstract: We present two patients in whom the combination of lesion site and cognitive performance was uniquely informative about the organisation and functional anatomy of semantic memory. One had had a single lobar stroke with an unusual distribution, largely destroying the whole of the left temporal lobe ventral to the superior temporal sulcus. The other patient had had herpes simplex encephalitis with destruction that was confined to the left cerebral hemisphere. The lesion again mainly encompassed the left temporal lobe, but also extended to the left inferior frontal gyrus. Cognitive outcomes in the two patients were compared with each other and with published results from patients with semantic dementia. This is because, whereas the majority of semantic dementia patients present with more prominent atrophy of the left rostroventral temporal lobe, they invariably have a degree of atrophy in the mirror region on the right that progresses. Semantic dementia therefore provides no clear evidence about the specific role of the left rostroventral temporal lobe. The two patients showed a highly consistent cognitive profile. Their deficits were also similar in many respects to that observed in patients with mild-moderate semantic dementia, including severe anomia that was not resolved by phonological cues and impairment on non-verbal as well as verbal semantic tasks. Certain key features of the semantic dementia profile, however-including sensitivity to the familiarity and typicality of the stimulus materials-appeared only in tasks requiring verbal output in these two patients with unilateral left temporal lesions. Results in these cases provide some of the first definitive evidence regarding the specific functions of the left anterior temporal lobe.
Related Organisations
University College London
Location: United Kingdom of Great Britain and Northern Ireland
Imperial College London
Location: United Kingdom of Great Britain and Northern Ireland
Imperial College Healthcare NHS Trust
Location: United Kingdom of Great Britain and Northern Ireland
Newcastle University
Location: United Kingdom of Great Britain and Northern Ireland
Related Funding Activities
Discovery Projects - Grant ID: DP200100127
Start Date: 07-2020
End Date: 12-2024
Amount: $526,690.00
Funder: Australian Research Council
View Funded ActivityInvestigation Of The Reorganisation Of Language And Verbal Memory Systems In Chronic Temporal Lobe Epilepsy.
Start Date: 2010
End Date: 2014
Funder: Medical Research Council
View Funded Activity