ORCID Profile
0000-0002-2321-8091
Current Organisations
King's College London
,
Guy's and Saint Thomas' NHS Foundation Trust
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Publisher: Springer Science and Business Media LLC
Date: 24-02-2040
Publisher: Society of Nuclear Medicine
Date: 11-10-2011
DOI: 10.2967/JNUMED.111.093724
Abstract: Inflammation and angiogenesis are hypothesized to be important factors contributing to plaque vulnerability, whereas calcification is suggested to confer stability. To investigate this in vivo, we combined CT angiography and PET and compared the findings with immunohistochemistry for patients undergoing carotid endarterectomy. Twenty-one consecutive patients (18 men, 3 women mean age ± SD, 68.3 ± 7.3) undergoing carotid endarterectomy were recruited for combined carotid (18)F-FDG PET/CT angiography. Plaque (18)F-FDG uptake was quantified with maximum standardized uptake value, and CT angiography quantified percentage plaque composition (calcium and lipid). Surgical specimens underwent ex vivo CT aiding image registration, followed by immunohistochemical staining for CD68 (macrophage density) and vascular endothelial growth factor (angiogenesis). Relationships between imaging and immunohistochemistry were assessed with Spearman rank correlation and multivariable regression. The mean (±SD) surgically excised carotid plaque (18)F-FDG metabolism was 2.4 (±0.5) versus 2.2 (±0.3) contralaterally (P = 0.027). There were positive correlations between plaque (18)F-FDG metabolism and immunohistochemistry with CD68 (ρ = 0.55 P = 0.011) and vascular endothelial growth factor (ρ = 0.47 P = 0.031). There was an inverse relationship between plaque (18)F-FDG metabolism and plaque percentage calcium composition on CT (ρ = -0.51 P = 0.018) and between calcium composition and immunohistochemistry with CD68 (ρ = -0.57 P = 0.007). Regression showed that maximum standardized uptake value and calcium composition were independently significant predictors of angiogenesis, and calcium composition was a predictor of macrophage density. We provide in vivo evidence that increased plaque metabolism is associated with increased biomarkers of angiogenesis and inflammation, whereas plaque calcification is inversely related to PET and histologic biomarkers of inflammation.
Publisher: Elsevier BV
Date: 05-2020
Publisher: BMJ
Date: 12-12-2017
DOI: 10.1136/GUTJNL-2017-315333
Abstract: Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes. RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers (n=71). Eight working groups (WG) were constituted: discovery science risk prevention early diagnosis and screening pathology curative treatment stage IV disease and living with and beyond CRC. A series of discussions led to development of draft papers by each WG, which were evaluated by a 20-strong patient panel. A final list of RGs and research recommendations (RR) was endorsed by all participants. Fifteen critical RGs are summarised below: RG1 : Lack of realistic models that recapitulate tumour/tumour micro/macroenvironment RG2 : Insufficient evidence on precise contributions of genetic/environmental/lifestyle factors to CRC risk RG3 : Pressing need for prevention trials RG4 : Lack of integration of different prevention approaches RG5 : Lack of optimal strategies for CRC screening RG6 : Lack of effective triage systems for invasive investigations RG7 : Imprecise pathological assessment of CRC RG8 : Lack of qualified personnel in genomics, data sciences and digital pathology RG9 : Inadequate assessment/communication of risk, benefit and uncertainty of treatment choices RG10 : Need for novel technologies/interventions to improve curative outcomes RG11 : Lack of approaches that recognise molecular interplay between metastasising tumours and their microenvironment RG12 : Lack of reliable biomarkers to guide stage IV treatment RG13 : Need to increase understanding of health related quality of life (HRQOL) and promote residual symptom resolution RG14 : Lack of coordination of CRC research/funding RG15 : Lack of effective communication between relevant stakeholders. Prioritising research activity and funding could have a significant impact on reducing CRC disease burden over the next 5 years.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Vicky Goh.