ORCID Profile
0000-0003-2740-3910
Current Organisation
University of Sydney
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Publisher: Wiley
Date: 11-01-2013
Publisher: Wiley
Date: 11-01-2013
Publisher: Wiley
Date: 11-01-2013
Publisher: SAGE Publications
Date: 2010
DOI: 10.1177/104063871002200134
Abstract: A 12-year-old chinchilla ( Chinchilla lanigera) developed a slow-growing, soft, fluctuating, nonpainful mass on the ventral neck with focally extensive alopecia over a period of approximately 8 months. On postmortem examination, an extensive, multilobulated, cystic, neoplastic mass extended subcutaneously over the ventral and lateral neck with metastatic spread to submandibular lymph nodes, spleen, liver, and lungs. Neoplastic cells were strongly positive for vimentin and pan-cytokeratin but were negative for alpha–smooth muscle actin, S100, and myosin no intracytoplasmic myofibrils were detected on phosphotungstic acid hematoxylin staining. Histologic and immunohistochemical examination of the mass led to a diagnosis of undifferentiated carcinoma of the salivary gland and contributes to the paucity of knowledge concerning neoplasia in chinchillas.
Publisher: Wiley
Date: 11-01-2013
Publisher: Elsevier BV
Date: 04-2018
Publisher: American Association of Zoo Veterinarians
Date: 12-01-2021
DOI: 10.1638/2020-0006
Publisher: Elsevier
Date: 2019
Publisher: Wiley
Date: 11-01-2013
Publisher: Wiley
Date: 24-03-2021
DOI: 10.1111/VCO.12683
Abstract: Mast cell tumours (MCT) have been documented in numerous species and mutations within the KIT proto-oncogene are implicated in the neoplastic biology of mast cells in humans, dogs and cats. This study determined high KIT gene nucleotide and Kit amino acid sequence homology between several species known to suffer mast cell neoplasia and especially high sequence conservation between the cheetah (Acinonyx jubatus) and domestic cat (Felis catus) KIT sequences. As a result, we hypothesised that KIT mutations would exist in the neoplastic DNA of four cheetahs diagnosed with MCT from a recent case series. PCR and Sanger sequencing identified conservative exon 6 KIT mutations in two of the four cheetahs. The mutations were different between the two cheetahs. Only wild-type DNA in exons 6, 8, 9 and 11 of KIT was observed in the MCTs of the remaining two cheetahs. Twenty cutaneous MCTs from domestic cats were collected for KIT mutation comparison. Twelve tumours possessed a mutation within KIT exons 6, 8 or 9 (60%, 95% CI 38.5%-81.5%). No mutations were detected in exon 11. There was no significant association between domestic feline MCT KIT mutation status and tumour histological grade (traditional schematic, P = .934 Sabattini 2-tier schematic, P = .762) or mitotic index (P = .750). KIT mRNA and Kit protein sequences are conserved across species but the role of KIT in feline MCT pathogenesis is not completely understood.
Publisher: Elsevier
Date: 2013
Publisher: Elsevier BV
Date: 2021
DOI: 10.1016/J.DCI.2020.103841
Abstract: Tetanus toxoids (TT) commercially available for use in horses and livestock are commonly used to vaccinate elephants and rhinoceros that are in human care. Although recommendations for booster intervals have changed in human and horse protocols to reduce the risks associated with hyper-immunity (i.e. B-cell anergy and hypersensitivity reactions) these have generally not been adopted in zoo protocols. Additionally, there is no evidence to demonstrate commercial TT immunogenicity in rhinoceros. In this study, a preliminary analysis of rhinoceros antibody responses to TT was conducted, in addition to an exploration of the impact of various booster frequencies on antibody responses in elephant. Retrospective analysis of archived serum s les was conducted for 9 Asian elephants (Elephas maximus), 7 southern black (Diceros bicornis minor), one southern white (Ceratotherium simum simum), and two greater one-horned (Rhinoceros unicornis) rhinoceros. Pre-vaccination (baseline) s les and those following priming vaccination (rhinoceros only), annual and non-annual boosters were targeted. A commercially available competitive ELISA kit was used to quantify serum anti-TT antibodies. Average baseline and post-vaccination anti-tetanus antibody concentrations were greater in elephant (92 mg/L ± 42, n = 3, N = 3 125 ± 76, n = 82, N = 9) than in rhinoceros (47 mg/L ± 39, n = 8, N = 8 44 mg/L ± 37, n = 16, N = 7). Rhinoceros antibody concentrations did not differ markedly following vaccinations from their naturally acquired high pre-vaccination concentrations. Eight elephants demonstrated antibody maintenance for 3-5 years without a tetanus booster. Additionally, although five out of nine elephants developed local reactions consistent with delayed type IV hypersensitivity following some boosters, there was no association between high antibody concentrations and increased incidence of adverse reactions. In addition, no decrease in antibody concentrations was detected as a result of annual vaccination in elephants, though this does not entirely rule out potential for B-cell anergy.
Publisher: Wiley
Date: 11-01-2013
Publisher: Royal Zoological Society of New South Wales
Date: 29-09-2023
DOI: 10.7882/AZ.2023.030
Publisher: American Association of Zoo Veterinarians
Date: 12-2010
DOI: 10.1638/2009-0250.1
Abstract: In December 2008, a southern white rhinoceros (ãsimum simum) aborted a 7-mo gestation male fetus. On hematoxylin and eosin-stained sections of fetal tissues, foci of necrosis were noted in the hepatic parenchyma and were associated with low numbers of lymphocytes, plasma cells, and neutrophils. Protozoal zoites were identified within the hepatic lesions and within the cerebellum. Evaluations utilizing immunohistochemistry, polymerase chain reaction, and DNA sequencing identified the protozoan as Neospora caninum. A microsatellite analysis using MS10 marker showed a unique trinucletoide repeat pattern (ACT), (AGA)19 (TGA)8 distinct from all studied N. caninum to date. This is the first report of N. caninum-related abortion of a rhinoceros fetus of any species and the first report of polymerase chain reaction-confirmed N. caninum infection in any rhinoceros.
Publisher: Elsevier
Date: 2012
Publisher: Wiley
Date: 11-01-2013
Publisher: Wiley
Date: 11-01-2013
Publisher: American Society for Microbiology
Date: 27-04-2023
DOI: 10.1128/JVI.01932-22
Abstract: Rhinoceros genomes were thought to be devoid of gammaretroviruses, as has been determined for other perissodactyls (horses, tapirs, and rhinoceros). While this may be true of most rhinoceros, the African white and black rhinoceros genomes have been colonized by evolutionarily young gammaretroviruses (SimumERV and DicerosERV for the white and black rhinoceros, respectively).
No related grants have been discovered for Michelle Campbell.