Alex Arnall

Age‐specific incidence rates and risk factors for respiratory syncytial virus‐associated lower respiratory tract illness in cohort children under 5 years old in the Philippines

Publisher: Wiley

Date: 19-03-2019

DOI: 10.1111/IRV.12639

Risk of Transmission and Viral Shedding From the Time of Infection for Respiratory Syncytial Virus in Households

Publisher: Oxford University Press (OUP)

Date: 03-07-2021

DOI: 10.1093/AJE/KWAB181

Abstract: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection worldwide, but reports of temporal changes in the risk of transmission among close contacts has been scarce. This study aimed to examine an association between the viral load trajectory and transmission risk to develop a better control strategy for the disease spread. We conducted a household-based prospective cohort study in Biliran Province, the Philippines, and enrolled 451 participants to observe the development of acute respiratory infection. Including the cases found at the health-care facility, we analyzed the data of viral loads with symptom records obtained from 172 followed participants who had household member positive for RSV with a rapid test during an RSV outbreak in 2018–2019. We developed a model estimating a temporal change in the viral shedding from the infection and evaluated transmission dynamics. We found that most transmission events occurred within approximately 7 days of the household exposure, including potential presymptomatic transmissions. The inferred risk of infection among those younger than 5 years was 3.5 times higher than that of those older than 5 years. This finding suggested that the initial week after the household exposure is particularly important for preventing RSV spread.

Association Between Preceding Viral Respiratory Infection and Subsequent Respiratory Illnesses Among Children: A Prospective Cohort Study in the Philippines

Publisher: Oxford University Press (OUP)

Date: 05-09-2018

DOI: 10.1093/INFDIS/JIY515

Incidence and Risk Factors of Childhood Pneumonia-Like Episodes in Biliran Island, Philippines—A Community-Based Study

Publisher: Public Library of Science (PLoS)

Date: 04-05-2015

DOI: 10.1371/JOURNAL.PONE.0125009

University Of Reading

Location: United Kingdom of Great Britain and Northern Ireland

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Tohoku University

Location: No location found

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Tohoku University Gradute School Of Medicine

Location: Japan

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Discovery Projects - Grant ID: DP190100604

Start Date: 06-2019

End Date: 12-2024

Amount: $445,000.00

Funder: Australian Research Council