ORCID Profile
0000-0003-0597-9468
Current Organisations
La Trobe University
,
Odense Universitetshospital
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Publisher: European Respiratory Society (ERS)
Date: 04-08-2022
DOI: 10.1183/23120541.00238-2022
Abstract: Phase III regulatory trials show that anti-interleukin (IL)-5 biologics efficiently reduce exacerbations and the use of maintenance oral corticosteroids (mOCS) in patients with severe eosinophilic asthma. However, patients eligible for these trials differ significantly compared with real-life severe asthma populations. Therefore, our aim was to explore efficacy in a real-life setting. The Danish Severe Asthma Register (DSAR) is a complete, nationwide register that comprises all Danish patients on biological therapy for severe asthma. This prospective study identified patients in the DSAR who were complete responders to anti-IL-5 biologics after 1 year of treatment. A complete response was defined as resolution of the parameter setting the indication, i.e. recurrent exacerbations and/or use of mOCS. A total of 289 out of 502 (58%) patients were complete responders to anti-IL-5 biologics after 12 months. Complete responders had greater improvements in forced expiratory volume in 1 s and Asthma Control Questionnaire (ACQ) score compared with noncomplete responders (Δ 210 versus 30 mL p .0001 and Δ −1.04 versus −0.68 p=0.016, respectively). A complete response was predicted by age at onset, less severe disease at baseline ( i.e. no mOCS and lower ACQ score) and higher blood eosinophils. More than half of Danish patients treated with anti-IL-5 biologics for severe asthma achieve a complete response to treatment, thereby becoming free from asthma exacerbations and the need for mOCS. Complete responders also achieved superior effects on lung function and symptoms compared with noncomplete responders.
Publisher: SAGE Publications
Date: 27-12-2020
Abstract: Anecdotal evidence suggests that tourists do not only choose tourism destinations based on objective quality criteria. Rather, tourists may be drawn to certain destinations for reasons such as feelings of connection or affinity. This article provides a first examination of tourism affinity (TAFF) and its effects on tourism behavior. Tourists who are high on TAFF feel sympathy, admiration, or attachment toward a given country. In addition to examining TAFF, we also test the impact of tourism animosity (TANI) on a variety of resident and tourism behaviors. The results show that TAFF is a positive driver of several tourism-related outcomes, such as word of mouth and resident hospitality, while TANI drives general intention to visit and provide word of mouth but is a barrier to closer interactions. In addition, goal compatibility, relative power, and moral obligation drive TAFF while relative power drives TANI.
Publisher: SAGE Publications
Date: 08-11-2019
Abstract: In iduals have demonstrated an attraction toward foreignness, which, arguably, constitutes a central reason to travel. Drawing on research from social and evolutionary psychology, the authors provide the first investigation of tourism xenophilia (TXI), which we define as in iduals’ attraction toward the perceived foreignness of destinations. Across three studies, the authors conceptualize, develop, and apply a reliable, valid, and parsimonious TXI scale. The results show that TXI explains several important tourist and resident behaviors, such as willingness to engage with locals, willingness to stay at a bed-and-breakfast, intention to try local food, resident hospitality, support for immigration policies, and travel to foreign destinations. The authors also empirically investigate three key antecedents of TXI: promotion focus, boredom proneness, and mind-wandering. Finally, implications for academics and practitioners are discussed.
Publisher: Elsevier BV
Date: 11-2020
Publisher: SAGE Publications
Date: 17-01-2022
DOI: 10.1177/00472875211067550
Abstract: Paradoxical at first sight, some tourists engage in activities involving negative emotions and even physical pain. Tourism scholars have begun investigating this phenomenon and have called for more of such research. Against this background, the authors introduce to tourism the notion of benign masochism, defining it as a trait describing a person’s tendency to embrace and seek pleasure through safely playing with a stimulating level of physical pain and negative emotions. In doing so, the authors root benign masochism in the notion of play from evolutionary psychology and develop a benign masochism scale that is able to predict various tourism outcomes, including willingness to visit a haunted house, to go on a challenging adventure holiday, and to visit a nuclear disaster site. The authors conclude by discussing theoretical and managerial implications as well as limitations and future opportunities for research.
No related grants have been discovered for Sofie Lock Johansson.