Publication
Hyperglycemia and Hypoglycemia Are Associated with In-Hospital Mortality among Patients with Coronavirus Disease 2019 Supported with Extracorporeal Membrane Oxygenation
Publisher:
MDPI AG
Date:
30-08-2022
DOI:
10.3390/JCM11175106
Abstract: Metabolic abnormalities, such as preexisting diabetes or hyperglycemia or hypoglycemia during hospitalization aggravated the severity of COVID-19. We evaluated whether diabetes history, hyperglycemia before and during extracorporeal membrane oxygenation (ECMO) support, and hypoglycemia were risk factors for mortality in patients with COVID-19. This study included data on 195 patients with COVID-19, who were aged ≥19 years and were treated with ECMO. The proportion of patients with diabetes history among nonsurvivors was higher than that among survivors. Univariate Cox regression analysis showed that in-hospital mortality after ECMO support was associated with diabetes history, renal replacement therapy (RRT), and body mass index (BMI) 18.5 kg/m2. Glucose at admission mg/dL and glucose levels before ventilator mg/dL were not associated with in-hospital mortality. However, glucose levels before ECMO mg/dL and minimal glucose levels during hospitalization mg/dL were associated with in-hospital mortality. Multivariable Cox regression analysis showed that glucose mg/dL before ECMO and minimal glucose mg/dL during hospitalization remained risk factors for in-hospital mortality after adjustment for age, BMI, and RRT. In conclusion, glucose mg/dL before ECMO and minimal glucose level mg/dL during hospitalization were risk factors for in-hospital mortality among COVID-19 patients who underwent ECMO.